Voltammetric determination of paracetamol in drugs using an electrode modified by poly(3,4-ethylendioxythiophene) film with a gold deposit

L.G. Shaidarova^*, A.V. Gedmina^**, I.E. Rogozhin^***, I.A. Chelnokova^****, H.C. Budnikov^*****

Kazan Federal University, Kazan, 420008 Russia

E-mail: ^*LarisaShaidarova@mail.ru, ^**Anna.Gedmina@kpfu.ru, ^***rogozhin.09@mail.ru, ^****Irina.Chelnokova@kpfu.ru, ^*****Herman.Budnikov@kpfu.ru

Received January 27, 2020

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DOI: 10.26907/2542-064X.2020.1.69-79

For citation: Shaidarova L.G., Gedmina A.V., Rogozhin I.E., Chelnokova I.A., Budnikov H.C. Voltammetric determination of paracetamol in drugs using an electrode modified by poly(3,4-ethylendioxythiophene) film with a gold deposit. Uchenye Zapiski Kazanskogo Universiteta. Seriya Estestvennye Nauki, 2020, vol. 162, no. 1, pp. 69–79. doi: 10.26907/2542-064X.2020.1.69-79. (In Russian)

Abstract

A composite film of poly-3,4-ethylenedioxythiophene (PEDOT) with a gold deposit (Au-PEDOT-GCE) on the surface of a glassy carbon electrode (GCE) shows electrocatalytic activity in the oxidation of paracetamol. Working conditions for the immobilization of the Au-PEDOT composite on the GCE were determined. A method for the voltammetric determination of paracetamol on Au-PEDOT-GCE was proposed. It was revealed that the dependence of the oxidation current of paracetamol on its concentration is linear in the range from 1·10^–7 to 1·10^–3 mol·L^–1. The developed voltammetric method was tested to determine paracetamol in drugs.

Keywords: composite film of poly-3,4-ethylenedioxythiophene with gold deposit, electrocatalysis, voltammetric determination of paracetamol

Acknowledgments. The study is performed according to the Russian Government Program of Competitive Growth of Kazan Federal University.

Figure Captions

Fig. 1. Cyclic voltammetrograms obtained from the EDOT solution in CH₃CN containing 0.1 M LiClO₄ with multiple potential cycling at the potential sweep rate of 70 mV/sec.

Fig. 2. Cyclic voltammetry on the GCE (curve 1) and PEDOT-GCE (curve 2) with paracetamol in a pH 6.86 phosphate buffer background (a), dependence of the oxidation current of paracetamol on its concentration (b).

Fig. 3. Dependence of the oxidation current of paracetamol on the PEDOT-GCE electrode on the conditions of PEDOT electropolymerization (potential cycling areas, number of cycles) (a) and on the number of film activation cycles (b).

Fig. 4. Cyclic voltammetry on the Au-GCE electrode without (curve 1) and with (curve 2) of paracetamol in a pH 6.86 phosphate buffer background.

Fig. 5. Dependence of the oxidation current of paracetamol on time (a) and potential (b) of deposition of gold particles on the PEDOT-GCE electrode.

Fig. 6. Dependence of the oxidation current of paracetamol on the PEDOT-GCE on the square root of potential superposition rate (a), on the potential superposition rate in logarithmic coordinates (b).

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