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Main page \ Research and Innovations \ Publications \ Publishing activities of KFU \ Uchenye Zapiski Kazanskogo Universiteta \ Uchenye Zapiski Kazanskogo Universiteta. Seriya Estestvennye Nauki \ Archive

Application of Omics Technologies in the System of Sports Training

E.A. Semenovaa*, E.V. Valeevab**, E.A. Boulyginaa***, S.I. Gubaydullinac****, I.I. Ahmetovb,d,e*****

aKazan Federal University, Kazan, 420008 Russia

bKazan State Medical University, Kazan, 420012 Russia

cVolga Region State Academy of Physical Culture, Sport and Tourism, Kazan, 420010 Russia

dSt. Petersburg Research Institute of Physical Culture, St. Petersburg, 191040 Russia

eFederal Scientific Clinical Center for Physical and Chemical Medicine,

Federal Medical-Biological Agency of Russia, Moscow, 119435 Russia

E-mail: *alecsekaterina@gmail.com, **vevaleeva@yandex.ru, ***boulygina@gmail.com, ****gubajdullina_svetlana@mail.ru, *****genoterra@mail.ru

Received March 27, 2017

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Abstract

Deciphering the human genome, and further development of omics technologies, have opened new opportunities in studying the molecular mechanisms underlying the sport success. According to modern concepts of functional genomics, it is believed that individual differences in the degree of development of physical and mental qualities, as well as in the susceptibility to different diseases of athletes are largely due to DNA polymorphisms. Genetic markers associated with the development and manifestation of physical qualities (speed, strength, endurance, agility, flexibility) can be used in the sports selection system, to clarify sports specialization and to optimize the training process. Other molecular markers (methyl groups, trans­cripts, telomerase activity, telomeres, circulating DNA, metabolites, proteins, etc.) in addition to predicting athletic performance, allow assessing the current functional state of the athlete, including the phenomenon of overtraining. The purpose of this review is to provide data on the use of genomic, epigenetic, trans­criptomic, proteomic and metabolic methods in sports talent identification, assessing the current functional status of athletes and in the pres­cription of personal training and nutrition programs. Future research, including multicentre genome-wide association studies and whole-genome sequencing in large cohorts of athletes with further validation and replication, will substantially contribute to the discovery of large numbers of the causal genetic variants (mutations and DNA polymorphisms) that would partly explain the heritability of athlete status and related phenotypes.

Keywords: DNA polymorphism, genome, epigenome, trans­criptome, proteome, metabolome,    biomarkers, telomeres, sports selection

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For citation: Semenova E.A., Valeeva E.V., Boulygina E.A., Gubaydullina S.I., Ahmetov I.I. Application of omics technologies in the system of sports training. Uchenye Zapiski Kazanskogo Universiteta. Seriya Estestvennye Nauki, 2017, vol. 159, no. 2, pp. 232–247. (In Russian)

Application of Omics Technologies in the System of Sports Training