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A series of lectures of leading scientists for students and postgraduates of Kazan Federal University
2016
15, 16, 17, 19 Dec
Lecturer: Serebrisky Ilya Genrikhovich, Doctor of Sciences in chemistry, Head of research laboratory "Molecular basis of the pathogenesis of neoplastic diseases". PhD Assistant Professor (h-index-21), Fox Chase Cancer Center FCCC, USA
Lectures will be held in the auditorium of the Eastern building of the main building (room 026)
Please come in advance so as not to distract the lecturer.
The invited listeners – please take care of the pass to the auditorium in advance!
Everyone is invited!
15 Dec
Time and place: 10.00 a.m., the Assembly hall of the East wing of the main building of Kazan Federal University (026 AUD.)
Theme: Systemic biology: problems and prospects
The stages of development of systemic biology. The properties of biological systems. Omix technology - main sources of information in systemic biology. Building models is a major task of systemic biology. Approaches to describe the metabolic and biochemical pathways at the global level. Models of individual processes, models of organisms, the first model of the living cell.
16 Dec
Time and place: 10.00 a.m., the Assembly hall of the East wing of the main building of Kazan Federal University (026 AUD.)
Lecture: Network interactions
The lecture will highlight the topological characteristics of networks: random, without a large-scale, hierarchical network. Network parameters: the clustering coefficient, the intermediate centrality, connectivity environment. Construction and visualization of networks.
17 Dec
The theme of the lecture: "Network topology"
Time and place: 15.30 in the auditorium.117V (East wing of the main building of KFU)
Practical session on building networks of interactions
Place and time: at 17.00 in AUD.116В (East wing of the main building of KFU)
Cytoscape. Familiarity with the interface. Popular plug-ins. Integration of analyses from R to Cytoscape. The use of online tools. GeneMania, String DB, GAM
19 Dec
Time and place: 10.00 a.m., the Assembly hall of the East wing of the main building of Kazan Federal University (026 AUD.)
The topic of the lecture: Interactomics
The lecture will provide an overview of experimental methods to study protein-protein interactions. Biochemical methods will be considered: chemical crosslinking, the joint fractionation in the process of chromatography, co-immunoprecipitation. Efficient and highly productive experimental methods such as yeast digibridge analysis, phage display, affinity purification in tandem with mass spectrometry. The expression of genes in yeast cells. Domain structure of the yeast transcription activator Gal4. Twohybrid yeast model system. Elements of yeast duhybrid system. Reporterne genes used in the yeast duhybrid system. Scheme of cDNA library screening to search for proteins that interact with a given protein X. Test the specificity of the interaction in duhybrid system.
20 Dec
Time and place: 10.00 a.m., the Assembly hall of the East wing of the main building of Kazan Federal University (026 AUD.)
The topic of the lecture: the Contribution of systemic biology to the development of molecular medicine
The lecture will discuss the main questions and problems of molecular medicine: the construction of global networks of genetic interactions; identification of biomarkers of diseases based on the study and modeling of biochemical pathways and modes of transmission of the signal; the identification of genes whose changes lead to disease. Familiarity with databases. Public resources. Cell miner. cBioPortal: a study of a single gene, the study of several genes
Jan-2017
LEADING SCHOOL – UNIVERSITY STUDENTS
Everyone is invited!
Lectures will be held in the auditorium of the Eastern main building of the University;
Beginning of lectures: 10.00;
"Structure and function of membranes" (3 lectures) associate Professor of biochemistry and molecular biology Medical School Center of Health Sciences of the University of Texas - Houston (USA), PhD in biology Bogdanov M.
In a series of lectures will cover issues of the hydrophobic effect and membrane structures: why membranes? Amphipathicity molecules. Detergents, micelles and visicula. The interaction of Protein-SDS. The interaction between protein and non-denatured detergents. Lipids: structure, function and physiological significance. Lipid asymmetry in bacterial membrane: content and physiological value. The structure of the protein membrane. Understanding of the folding, insertion and translocation of membrane proteins. The water-solubility-protein interactions. Association of lipid and protein complexes with membrane.
Jan-2017
"Lipid-assisted Membrane Protein Folding: Implications to Membrane-Linked Protein Folding Disorders" (2 lectures) - associate Professor of biochemistry and molecular biology Medical School Center of Health Sciences of the University of Texas - Houston (USA) PhD in biology Bogdanov M.
In a series of lectures will cover issues based on the discoveries of the authors of the first molecular chaperone non protein origin (lipochaperone) and its application.
March-2017
"Introduction to structural biology of macromolecular complexes of the cell and the mechanism of protein biosynthesis" Head of laboratory "Ribosome structure and function", Department of Integrated Structural Biology IGBMC, Strasbourg, France, honorary doctor of KFU Yusupov M.
In a series of lectures will highlight issues of cryo-electron microscopy and x-ray analysis as the main methods for structural studies of the mechanism of protein synthesis system of the cell.
Biochemical approaches to the allocation of large complexes of nucleic acids with proteins and characterization of their structure. Crystallization of the ribosome and its functional complexes for x-ray crystallography. Cryo-electron microscopy of ribosomal complexes. Comparison of the structure of ribosomes in prokaryotes and eukaryotes.
The mechanism of protein synthesis, initiation, elongate, termination and re-Cycling. The mechanism for decoding messenger RNA. The mechanism of formation of peptide bonds. The mechanism of translocation. Structural basis of the mechanism of inhibition of the system of protein synthesis and development of antibacterial, antifungal and anticancer drugs.
The APR-2017
"Introduction to comparative and functional genomics"
Deputy Director for science of the Institute of information transmission problems named A. A. Kharkevich of RAS, Professor of the SKOLKOVO Institute of science and technology, faculty of bioengineering and bioinformatics, Moscow state University, faculty of computer Sciences of the Higher school of Economics, DSc, Gelfand M.
In a series of lectures will cover the questions:
1.Functional annotation of genomes: challenges, methods, and examples
2.Evolution of regulatory interactions in bacteria.
Outdoor science club: NSG model (assistant Kozlova Olga)
Outdoor science club: Data mining (assistant Kozlova Olga)
May-2017
"Modern ideas about the cytoskeleton: microfilaments andmicrotubules" Professor of cell biology and histology, Moscow state University, DSс Vorobjev I. (3-5 lectures)
In a series of lectures will highlight the problems of dynamics of microtubules and cell motility. Common problems of apoptosis. Methodological developments: multi-color flow cytometry with imaging, cell sorting; high-performance intravital microscopy.
