2025
2024
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Romanova V.A, Kupriyanova O.V, Grigoryeva T.V, Potential for bioremediation of hydrocarbon-contaminated water by alkane-oxidizing actinobacteria//Limnology and Freshwater Biology. - 2024. - Vol.2024, Is.4. - P.1066-1071.
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Khilyas, I.V. Genomic insights and anti-phytopathogenic potential of siderophore metabolome of endolithic Nocardia mangyaensis NH1 / I.V. Khilyas, I.V., M.I. Markelova, L.R. Valeeva, T.M. Ivoilova, E. Shagimardanova, A.V. Laikov, A.A. Elistratova, E.S. Berkutova, G. Lochnit, M.R. Sharipova// Sci Rep. - 2024. - 14, 5676.
Khilyas_et_al.__2024.pdf
2023
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Martynova E, Khaibullin T, Salafutdinov I, Seasonal Changes in Serum Metabolites in Multiple Sclerosis Relapse//International Journal of Molecular Sciences. - 2023. - Vol.24, Is.4. - Art. №3542.
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Ishkaeva R.A, Salakhieva D.V, Garifullin R, A new triphenylphosphonium-conjugated amphipathic cationic peptide with improved cell-penetrating and ROS-targeting properties//Current Research in Pharmacology and Drug Discovery. - 2023. - Vol.4, Is.. - Art. №100148.
- Пат. 2799310 Российская Федерация, С07К 5/107, А61К 38/07, А61Р39/06. Трифенилфосфониевые производные тетрапептида, обладающие антиоксидантной активностью / Т.И. Абдуллин, Р.А. Ишкаева, М.И. Камалов, Р.И. Гарифуллин, Д.В. Салахиева, А.В. Лайков. - № 2022134156; заявл. 23.12.2022 ; опубл. 04.07.2023, Бюл. № 19.
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Tsepaeva O.V, Salikhova T.I, Ishkaeva R.A, Bifunctionalized Betulinic Acid Conjugates with C-3-Monodesmoside and C-28-Triphenylphosphonium Moieties with Increased Cancer Cell Targetability//Journal of Natural Products. - 2023. - Vol.86, Is.8. - P.1939-1949.
- O.V. Tsepaeva, T.I. Salikhova, R.A. Ishkaeva, A.V. Kundina, T.I. Abdullin, A.V. Laikov, M.V. Tikhomirova, L.R. Idrisova, A.V. Nemtarev, V.F. Mironov/ Bifunctionalized betulinic acid conjugates with C-3-monodesmoside and C-28-triphenylphosphonium moieties with increased cancer cell targetability// Journal of Natural Products. - 2023. 86(8). P. 1939-1949.
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Siniagina, M.N. Hydrogen sulfide-producing Escherichia coli strains in a patient with Crohn's colitis: a clinical case / M.N. Siniagina, A.V. Laikov, M.I. Markelova, E.A. Boulygina, N.A. Danilova, E.A. Sultanbekova, S.R. Abdulkhakov, T.V. Grigoryeva // FEBS Open Bio. - 2023. - V. 13 (Suppl. S2). - P. 159.
abstract_FEBS2023.pdf
2022
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Lopukhov L.V, Balandina A.V, Nigmatullina L.S, Evaluation of multiple reaction monitoring cubed performed by a quadrupole-linear ion trap mass spectrometer for quantitative determination of 6-sulfatoxymelatonin in urine//Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. - 2022. - Vol.1190, Is.. - Art. №123094.
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Lopukhov LV, Balandina AV, Nigmatullina LS, Mullakhmetova AF, Synbulatova GE, Laikov AV, Lopukhov VL, Grigoryeva TV. Evaluation of multiple reaction monitoring cubed performed by a quadrupole-linear ion trap mass spectrometer for quantitative determination of 6-sulfatoxymelatonin in urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2022 Feb 1;1190:123094. doi: 10.1016/j.jchromb.2021.123094. Epub 2022 Jan 10. PMID: 35030474.
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Iskhakova Z.I., Zhuravleva D.E., Heim C., Hartmann M.D., Laykov A.V., Forchhammer K., Kayumov A.R. PotN represents a novel energy-state sensing PII subfamily, occurring in firmicutes // FEBS Journal. - 2022.
- С. 2022623651, Российская Федерация. База данных факторов вирулентности комменсальных Escherichia coli / Синягина М.Н., Маркелова М.И., Лайков А.В., Булыгина Е.А., Григорьева Т.В.; № 2022623511; опубл. 23.12.2022.
- Hamza S. Prolonged immune response induced by sputnik V vaccine / S. Hamza, E. Martynova, E. Garanina, M. Markelova, V. Shakirova, Y. Davidyuk, V. Lezhnyova, A. Laikov, A. Rizvanov, S. Khaiboullina // EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. - 2022. - Vol.52, Special Is.1 - P.121.
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Siniagina M.N, Laikov A.V, Markelova M.I, Competitive ability of Escherichia coli strains in the intestinal microbiota of patients with Crohn's disease and healthy volunteers: physiological, biochemical and genetic characteristics//Zhurnal Mikrobiologii Epidemiologii i Immunobiologii. - 2022. - Vol.99, Is.6. - P.669-681.
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Ishkaeva R.A, Zoughaib M, Laikov A.V, Probing Cell Redox State and Glutathione-Modulating Factors Using a Monochlorobimane-Based Microplate Assay//Antioxidants. - 2022. - Vol.11, Is.2. - Art. №391.
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Romanova V, Markelova M, Boulygina E, Significance of both alkB and P450 alkane-degrading systems in Tsukamurella tyrosinosolvens: proteomic evidence // Applied Microbiology and Biotechnology. - 2022. - 106 (8). - pp. 3153-3171.
2021
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Lo Sasso G, Khachatryan L, Kondylis A, Inflammatory Bowel Disease-Associated Changes in the Gut: Focus on Kazan Patients//Inflammatory bowel diseases. - 2021. - Vol.27, Is.3. - P.418-433.
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Georgij Arapidi, Anatoly Urban, Victoria Shender, Ivan Butenko, Olga Bukato, Alexandr Kuznetsov, Olga Ivanova, Leonid Lopukhov, Alexander Laikov, Nina Sharova, Margarita Nikonova, Alexandr Mitin, Alexandr Martinov, Tatiana Grigorieva, Elena Ilina, Vadim Ivanov, Vadim Govorun / Identification and analysis of exogenous peptides in human blood serum and plasma: Search for potential agents of interaction between the intestinal microbiota and the human body // FASEB Journal Volume35, IssueS1, Special Issue: Experimental Biology 2021 Meeting Abstracts
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Markelova M. TRANSCRIPTOMIC INSIGHT INTO IN VITRO INTERACTION OF ESCHERICHIA COLI WTH IMMUNOGLOBULIN A AS A MODEL OF THE INFLAMMATORY BOWEL DISEASE PATHOGENESIS / Markelova M., Siniagina M., Baichurina I., Laikov A., Boulygina E., Shah Mahmud R., Semin I., Kruglov A., Matuyshkina D., Musarova V., Grigoryeva T. // United European Gastroenterology Journal - October 2020. - Vol.8 (8) - P. 317.
F_UEG2020.pdf -
Siniagina M.N, Markelova M.I, Boulygina E.A, Diversity and adaptations of escherichia coli strains: Exploring the intestinal community in crohn?s disease patients and healthy individuals//Microorganisms. - 2021. - Vol.9, Is.6. - Art. № 1299.
- Shaimardanova AA, Chulpanova DS, Solovyeva VV, Serum Cytokine Profile, Beta-Hexosaminidase A Enzymatic Activity and GM(2) Ganglioside Levels in the Plasma of a Tay-Sachs Disease Patient after Cord Blood Cell Transplantation and Curcumin Administration: A Case Report//LIFE-BASEL. - 2021. - Vol.11, Is.10. - Art. №1007.
- Salafutdinov I., Laikov A., Lopuhov L., Metabolic signatures in a mouse model of progressing amyotrophic lateral sclerosis//EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. - 2021. - Vol.51, Is.. - P.114-115.
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Shaimardanova A.A, Chulpanova D.S, Solovyeva V.V, Serum cytokine profile, beta-hexosaminidase a enzymatic activity and gm2 ganglioside levels in the plasma of a tay-sachs disease patient after cord blood cell transplantation and curcumin administration: A case report//Life. - 2021. - Vol.11, Is.10. - Art. №1007.
- Siniagina M., Markelova M., Boulygina E., Antibiotic resistome profiles of fecal Escherichia coli isolates in association with Crohn's disease//JOURNAL OF CROHNS & COLITIS. - 2021. - Vol.15, Is.. - P.S601-S602.
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Gorovtsov A, Demin K, Sushkova S, The effect of combined pollution by PAHs and heavy metals on the topsoil microbial communities of Spolic Technosols of the lake Atamanskoe, Southern Russia//Environmental Geochemistry and Health. - 2021. - Vol. 44. - P. 1299–1315.
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Siniagina, Maria N., et al. Diversity and Adaptations of Escherichia coli Strains: Exploring the Intestinal Community in Crohn's Disease Patients and Healthy Individuals // Microorganisms. - 2021. - V.9. - N.6. - P.1299.
2020
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Siniagina M, Markelova M, Laikov A, Cultivated Escherichia coli diversity in intestinal microbiota of Crohn's disease patients and healthy individuals: Whole genome data//Data in Brief. - 2020. - Vol.28, Is.. - Art. № 104948.
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I.I. Mukhamatdinov, I.Sh.S. Salih, I.Z. Rakhmatullin, S.A. Sitnov, A.V. Laikov, V.V. Klochkov, A.V. Vakhin. Influence of Co-based catalyst on subfractional composition of heavy oil asphaltenes during aquathermolysis, Journal of Petroleum Science and Engineering, 2020, 186, 106721.
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Romanova, Y.; Laikov, A.; Markelova, M.; Khadiullina, R.; Makseev, A.; Hasanova, M.; Rizvanov, A.; Khaiboullina, S.; Salafutdinov, I. Proteomic Analysis of Human Serum from Patients with Chronic Kidney Disease. Biomolecules 2020, 10, 257.
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Romanova Y, Laikov A, Markelova M, Proteomic analysis of human serum from patients with chronic kidney disease//Biomolecules. - 2020. - Vol.10, Is.2. - Art. № 257.
- Gomzikova Marina O., Zhuravleva Margarita N., Vorobev Vyacheslav V., Angiogenic Activity of Cytochalasin B-Induced Membrane Vesicles of Human Mesenchymal Stem Cells//CELLS. - 2020. - Vol.9, Is.1. - Art. №95.
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Kurbangaleeva S. Proteome analysis of mesenchymal stem cells derived microvesicles / S. Kurbangaleeva, I. Salafutdinov, A. Laikov, D. Gatina, A. Rizvanov, M. Gomzikova // EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. – 2020. – Vol. 50. – P. 84-84.
Tezis_1._ESCI.pdf -
Garipov M.R. Targeting pathogenic fungi, bacteria and fungal-bacterial biofilms by newly synthesized quaternary ammonium derivative of pyridoxine and terbinafine with dual action profile / M.R. Garipov, A.E. Sabirova, R.S. Pavelyev, N.V. Shtyrlin, S.A. Lisovskaya, O.V. Bondar, A.V. Laikov, Ju.G. Romanova, M.I. Bogachev, A.R. Kayumov, Yu.G. Shtyrlin // Bioorganic Chemistry. – 2020. – V.104. – 104306.
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Ulyanova V, Mahmud R.S, Laikov A, Anti-influenza activity of the ribonuclease binase: Cellular targets detected by quantitative proteomics//International Journal of Molecular Sciences. - 2020. - Vol.21, Is.21. - P.1-23.
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Ulyanova, V.; Shah Mahmud, R.; Laikov, A.; Dudkina, E.; Markelova, M.; Mostafa, A.; Pleschka, S.; Ilinskaya, O. Anti-Influenza Activity of the Ribonuclease Binase: Cellular Targets Detected by Quantitative Proteomics. Int. J. Mol. Sci. 2020, 21, 8294.
- Kurbangaleeva S., Salafutdinov I., Laikov A., Proteome analysis of mesenchymal stem cells derived microvesicles//EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. - 2020. - Vol.50, Is.. - P.84-84.
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Deviatiiarov R, Ayupov R, Laikov A, Diversity and regulation of S-adenosylmethionine dependent methyltransferases in the anhydrobiotic midge//Insects. - 2020. - Vol.11, Is.9. - P.1-11.
2019
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Martykanova D.S, Davletova N.C, Zemlenuhin I.A, Skin Microbiota in Contact Sports Athletes and Selection of Antiseptics for Professional Hygiene//BioMed Research International. - 2019. - Vol.2019, Is.. - Art. № 9843781.
- Romanova Valeriya A., Boulygina Eugenia A., Siniagina Maria N., Draft Genome Sequence of a Medium- and Long-Chain n-Alkane-Degrading Bacterium, Tsukamurella tyrosinosolvens Strain PS2, with Two Genetic Systems for Alkane Degradation//MICROBIOLOGY RESOURCE ANNOUNCEMENTS. - 2019. - Vol.8, Is.17. - Art. №e00218-19.
- Siniagina M. No difference in the distribution of pathogenic factors found in Escherichia coli isolates from patients with Crohn's disease and healthy individuals / Siniagina M., Markelova M., Laikov A., Boulygina E., Khusnutdinova D., Kharchenko A., Fedorova M., Romanova V., Grigoryeva T. // United European Gastroenterology Journal - October 2019. - Vol.7 (8S) - P. 870.
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Siniagina M. Cultivated Escherichia coli diversity in intestinal microbiota of Crohn's disease patients and healthy individuals: whole genome data / Siniagina M., Markelova M., Laikov A., Boulygina E., Khusnutdinova D., Kharchenko A., Misbakhova A., Grigoryeva T. //Data in Brief. – 2019. – V. 28. - P. 104948.
F_DatainBrief2019.pdf - Sharafutdinov I., Pavlova A., Laykov A., Proteomic changes in Bacillus subtilis caused by overexpression of HtrA protease//FEBS OPEN BIO. - 2019. - Vol.9, Is.. - P.427-427.
2018
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Kamalov M.I, Dang Tr, Petrova N.V, Self-assembled nanoformulation of methylprednisolone succinate with carboxylated block copolymer for local glucocorticoid therapy//Colloids and Surfaces B: Biointerfaces. - 2018. - Vol.164, Is.. - P.78-88.
- Siniagina M.N. Crohn's disease-associated Escherichia coli serotyping through the whole-genome sequencing of cultivated intestinal community / M.N. Siniagina, M.I. Markelova, A.V. Laikov, E.A. Boulygina, T.V. Grigoryeva // 5th European Congress of Immunology ECI2018: abstract book. - P. 432
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Lopukhov L.V, Laikov A.V, Romanova V.A, LC-MS Method Development for Simultaneous Determination of Trans-3?-hydroxycotinine and Three Mercapturic Acids in Urine//BioNanoScience. - 2018. - Vol.8, Is.3. - P.924-929.
2017
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Martykanova D. S. et al. Characterization of Dysbiotic Changes of Skin Microbiota in Contact Sports Athletes / Dilyara S. Martykanova, Nailja Ch. Davletova, Ilya A. Zemlenuhin, Salavat M. Mugallimov, Azat M. Ahatov, Nazira S. Karamova, Sergey Yu. Malanin, Alexander V. Laikov, Maria I. Markelova, Maria N. Siniagina, Eugenia A. Boulygina, Tatyana V. Grigoryeva // BioNanoScience – 2016. - Vol.7,Is.1. - P. 1-3
Characterization_of_Dysbiotic_Changes_of_Skin_Microbiota_in_Contact_Sport_Athletes.pdf -
Romanova, Y.D. Cytokine Levels in the Serum of Patients with Chronic Kidney Insufficiency Before and After Hemodialysis / Y. D. Romanova, M. I. Markelova, A. V. Laikov, L. I. Fakhrutdinova, M. I. Hasanova, S. Yu. Malanin, V. M. Chernov, I. I. Salafutdinov, S. F. Khaiboullina // BioNanoScience, 7(2), 415-418
10.1007_s12668_016_0379_6.pdf -
Romanova Y.D, Markelova M.I, Laikov A.V, Cytokine Levels in the Serum of Patients with Chronic Kidney Insufficiency Before and After Hemodialysis//BioNanoScience. - 2017. - Vol.7, Is.2. - P.415-418.
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Sitnov S.A, Vakhin A.V, Mukhamatdinov I.I, Aquathermolysis of heavy oil in reservoir conditions in the present of ultradispersed co-based catalyst//International Multidisciplinary Scientific GeoConference Surveying Geology and Mining Ecology Management, SGEM. - 2017. - Vol.17, Is.15. - P.45-52.
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Laikov A.V., Markelova M.I., Makseev A., Hasanova M.I., Salafutdinov I.I., Romanova Y.D. Immune responses in patients with chronic renal failure before and after transplantation // The FEBS Journal. 2017, 284(S1):147-148.
febs_Immune_responses.pdf - Romanova V. A., Boulygina E. A., Grigoryeva T. V., Comparison of virulence factors in clinical and environmental strains of actinobacterium Tsukamurella tyrosinosolvens based on whole-genome sequencing.//MOLECULAR BIOLOGY OF THE CELL. - 2017. - Vol.28, Is.. - .
- Sitnov S.A., Vakhin A.V., Mukhamatdinov I.I., Batalin G.A., Laikov A.V Aquatermolysis of heavy oil in reservoir conditions with the use of ultradispersed Co-based catalyst // 17th International Multidisciplinary Scientific GeoConference. – SGEM 2017. – V. 17. – Is. 15. – P. 45-52. (DOI: 10.5593/sgem2017H/15/S06.006)
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Martykanova D.S, Davletova N.C, Zemlenuhin I.A, Characterization of Dysbiotic Changes of Skin Microbiota in Contact Sports Athletes//BioNanoScience. - 2017. - Vol.7, Is.1. - pp 1-3.
Martykanova.pdf
2016
2015
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Хиляс И.В. Микробные сидерофоры: классификация, применение, детекция и идентификация / И.В.Хиляс, А.В.Лайков, М.Р.Шарипова , Л.М.Богомольная - 2015. - 21 с.
Siderofory_final.pdf -
Ulyanova V.V. Preparations of Bacillus pumilus secreted RNase: One enzyme or two? / V.V. Ulyanova, V.S. Khodzhaeva, E.V. Dudkina, A.V. Laikov, V.I. Vershinina, O.N. Ilinskaya // Microbiology (Russian Federation). - 2015 - V. 84, I. 4. - P. 491-497. doi: 10.1134/S0026261715040177.
2015_Preparations_of_Bacillus_pumilus_secreted_RNase.pdf - Dao L. Full-scale bioreactor pretreatment of highly toxic wastewater from styrene and propylene oxide production / Dao L, Grigoryeva T, Laikov A, Devjatijarov R, Ilinskaya O // Ecotoxicol Environ Saf, Volume 108, October 2014, Pages 195-202
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Григорьева Т.В. Свойства бактерий, стимулирующих рост растений (plant-growth promoting rhizobacteria (PGPR)) / Т.В.Григорьева, Т.В.Хиляс, А.В.Лайков - Казань: Изд-во Казан. ун-та, 2015 . - 19 с.
Metodichka_PGPR_final.pdf
2014
2013
| Work address: | 9 Parizhskoy Kommuny Str., Kazan, Academic and Research Centre of the Institute of Fundamental Medicine and Biology |
| Phone: | 88432924269 |
| E-mail: | AVLajkov@kpfu.ru |
| Google scholar: | https://scholar.google.com/citations?user=DhPrEZsAAAAJ&hl=ru |
| Scientific and pedagogical experience: |
| General experience: |
| Experience in KFU: |
