Senior Lecturer at the Department of Inorganic Chemistry Mikhail Bukharov talks about his work funded by a grant from the Russian Foundation for Basic Research.
“We study the ties between complex compounds and their dynamic behavior in a solution, - says Mr. Bukharov. – We use copper with amino acids and some oligopeptides as models”. Amino acids and copper are both essential for human metabolism, so the research group can study their functioning mechanisms.
The practical result here is the development of antineoplastic medications that consist of amino acids and microelements. Thus the research can help make some progress in oncological treatments.
“By now we have studied some copper and amino acid complexes and presented our research results in such journals as Physical Chemistry Chemical Physics and Inorganic Chemistry, - continues Mr. Bukharov. – We managed to prove that the coordination number of copper (II) in solution, i. e. the specific number of ligands that attach to a copper ion depends on ligands themselves. There was a theory that copper (II) in solution only has six coordination positions for ligand attachment, but since early 2000s there have been publications about potential penta- or tetracoordination of copper (II). We proved that a number of coordination positions depends on ligands themselves – the stronger their binding the more probable pentacoordination structure is”.
The results have been discussed at several international conferences. The research group also uses mathematical modelling in their work through quantum chemistry and molecular dynamics methods.
The group consists of four researchers whose work also involves the Department of Quantum Electronics and Radio Spectroscopy of KFU and Ilmenau University of Technology.