Chemical Biology Group was established in 2015 by Dr. Emil Bulatov, graduate of Cambridge University. The research in the group is focused at the interface between chemistry and biology.
Dr. Emil Bulatov, Ph.D., M.Phil.
Main directions of research:
- The role of the Ubiquitin Proteasome System in cancer, autoimmune and neurodegenerative diseases
- MDM2 E3 ubiquitin ligase inhibitors: molecular and cellular mechanisms of action
- Screening for novel biologically active molecules
- Functional modification of proteins
1. Bulatov, E., Martin, E. M., Chatterjee, S., Knebel, A., Shimamura, S., Konijnenberg, A., Johnson, C., Zinn, N., Grandi, P., Sobott, F., Ciulli, A. Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2). J. Biol. Chem. 2015, 290, 4178–4191.
(IF = 4.573)
2. Bulatov, E. and Ciulli, A. Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation. Biochem. J. 2015, 467, 365–386.
(IF = 4.396)
3. Gadd, M. S., Bulatov, E. and Ciulli, A. Serendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases. PLoS ONE 2015, 10, e0131218.
(IF = 3.234)
- Russian Foundation for Basic Research (RFBR)
- Foundation for Promotion of Innovation