2016, In this study using the model of sciatic nerve transection in rats the cytokine profile of peripheral blood
serum and rat sciatic nerve fragments were measured 3, 7 and 14 days after the injury. Histological analysis of
sciatic nerve longitudinal sections was carried out at the same periods of time. The cytokine profile of peripheral
blood serum of an intact rat as well as the cytokine profile of an intact homogenized sciatic nerve of a rat was
examined. Comparative study of changes in quantitative measures before and after the injury was carried out.
It was shown that in peripheral blood serum after the sciatic nerve transection there was a change in
quantitative measures of IL-1a, Leptin, IL6, MCP1, MIP-2. In the samples of the rat sciatic nerve the changes were
found in the levels of EGF, Fractalkine, G-CSF, IFNg, IL10, IL17A, IL18, IL2, IL6, IP10, Leptin, LIX, MCP1,
MIP-1a, MIP-2, RANTES.