Публикации НИЛ Структурная биология

Наиболее значимые публикации 2016-2025 гг.

1. Vasilchenko A.S., Lukyanov D.A., Dilbaryan D.S., Usachev K.S., Poshvina D.V., Taldaev A., Nikandrova A.A., Imamutdinova A.N., Garaeva N.S., Bikmullin A.G., Klochkova E.A., Rusanov A.L., Romashin D.D., Luzgina N.G., Osterman I.A., Sergiev P.V., Teslya A.V. Macrolactin A Is an Inhibitor of Protein Biosynthesis in Bacteria // Biochimie. – 2025. – V. 232. – P. 25-34.  doi: 10.1016/J.BIOCHI.2025.01.003
2. Kolosova O., Zgadzay Yu., Stetsenko A., Sukhinina A.P., Atamas A., Validov Sh., Rogachev A., Usachev K., Jenner L.B., Dmitriev S.E., Yusupova G., Guskov A., Yusupov M. Mechanism of the read-through enhancement by aminoglycosides and mefloquine // Proc. Natl. Acad. Sci. USA. – 2025. – V. 122 (17). – P. e2420261122. Doi:10.1073/pnas.2420261122
3. Garaeva N., Fatkhullin B., Murzakhanov F., Gafurov M., Golubev A., Bikmullin A., Glazyrin M., Kieffer B., Jenner L., Klochkov V., Aganov A., Rogachev A., Ivankov O., Validov Sh., Yusupov M., Usachev K. Structural aspects of RimP binding on small ribosomal subunit from Staphylococcus aureus // Structure. – 2024. – V. 32. – P. 74-82 https://doi.org/10.1016/j.str.2023.10.014
   
4. Bikmullin A.G., Fatkhullin B., Stetsenko A., Gabdulkhakov A., Garaeva N., Nurullina N., Klochkova E., Golubev A., Khusainov I., Trachtmann N., Blokhin D., Guskov A., Validov Sh., Usachev K., Yusupov M. Yet another similarity between mitochondrial and bacterial ri-bosomal small subunit biogenesis obtained by structural char-acteristic of RbfA from S. aureus // International Journal of Molecular Science. – 2023. – V. 24(3). – article number 2118. Doi: 10.3390/ijms24032118
5. Zgadzay Y., Kolosova O., Stetsenko A., Wu Ch., Bruchlen D., Usachev K., Validov Sh., Jenner L., Rogachev A., Yusupova G., Sachs M.S., Guskov A., Yusupov M. E-site drug specificity of the human pathogen Candida albicans ribosome // Science Advances. – 2022. – V. 8. – article number eabn1062 doi:10.1126/sciadv.abn1062
6. Antonets K.S., Belousov M.V., Sulatskaya A.I., Belousova M.E., Kosolapova A.O., Sulatsky M.I., Andreeva E.A., Zykin P.A., Malovichko Y.V. Shtark O.Y., Lykholay A.N., Volkov K.V., Kuznetsova I.M., Turoverov K.K.,  Kochetkova E.Y., Bobylev A.G., Usachev K.S., Demidov O.N., Tikhonovich I.A., Nizhnikov A.A. Accumulation of storage proteins in plant seeds is mediated by amyloid formation // PLOS Biology. – 2020. – V. 18(7). – Article number e3000564. doi:10.1371/journal.pbio.3000564 J
7. Khusainov I., Fatkhullin B., Pellegrino S., Bikmullin A., Liu W., Gabdulkhakov A., Al Shebel A., Golubev A., Zeyer D., Trachtmann N., Sprenger G.A., Validov Sh., Usachev K., Yusupova G., Yusupov M. An integrative structural biology approach reveals a conserved mechanism of ribosome shutdown by the Staphylococcus aureus RsfS protein at atomic level // Nature communications. – 2020. – V. 11. – article number 1656.
8. Golubev A., Fatkhullin B., Khusainov I., Jenner L., Gabdulkhakov A., Validov Sh., Yusupova G., Yusupov M., Usachev K. Cryo-EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 Å resolution // FEBS Letters. – 2020. – doi:10.1002/1873-3468.13915

9. Key  F.M., Posth C., Esquivel-Gomez L.R., Hübler R., Spyrou M.A., Neumann G.U., Furtwängler A., Sabin S., Burri M., Wissgott A., Lankapalli A.K., Vågene A.J., Meyer M., Nagel S., Tukhbatova R., Khokhlov A., Chizhevsky A.,  Hansen S., Belinsky A.B., Kalmykov A., Kantorovich A.R., Maslov V.E., Stockhammer P.W., Vai S., Zavattaro M., Riga A., Caramelli D., Skeates R., Beckett J., Gradoli M., Steuri N., Hafner A., Ramstein M., Siebke I., Lösch S., Erdal Y.S., Alikhan N.-F., Zhou Z., Achtman M., Bos K., Reinhold S., Haak W., Kühnert D., Herbig A., Krause J. Emergence of human-adapted Salmonella enterica is linked to the Neolithization process // Nature Ecology & Evolution. – 2020. - doi.org/10.1038/s41559-020-1106-9

10. Rozov A. Importance of potassium ions for ribosome structure and function revealed by long-wavelength X-ray diffraction / A.Rozov, I. Khusainov, K.E. Omari, R.Duman, V.Mykhaylyk, M.Yusupov, E.Westhof, A.Wagner, G.Yusupova // Nature Communications. - 2019. - V.10, Article number 2519 
11. Spyrou M.A. Phylogeography of the second plague pandemic revealed through analysis of historical Yersinia pestis genomes / M.A. Spyrou, M.Keller, R.I. Tukhbatova, Ch.L. Scheib, E.A. Nelson, A.A. Valtueña, G.U. Neumann, D. Walker, A. Alterauge, N. Carty, C. Cessford, H. Fetz, M. Gourvennec, R. Hartle, M. Henderson, K. von Heyking, S.A. Inskip, S. Kacki, F.M. Key, E.L. Knox, Ch.Later, P. Maheshwari-Aplin, J. Peters, J.E. Robb, J. Schreiber, T. Kivisild, D. Castex, S. Lösch, M. Harbeck, A. Herbig, K.I. Bos, J. Krause // Nature Communications. - 2019. - V.10, Article number 4470
12. Pellegrino S. Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome / S.Pellegrino,  M.Meyer,  Z.A.Könst, M.Holm,  V.K.Voora,  D.Kashinskaya, C. Zanette, D.L. Mobley, G. Yusupova, C.D. Vanderwal, S.C. Blanchard, M. Yusupov // Nucleic acids research. - 2019. - V. 47(6). - P. 3223-3232
13. Usachev K.S. Solution structure of the N-terminal domain of the Staphylococcus aureus Hibernation Promoting Factor / K.S. Usachev, S.Z. Validov, I.Sh. Khusainov, V.V. Klochkov, A.V. Aganov,  M.M. Yusupov // Journal of Biomolecular NMR. – 2019. – V. 73(5). – P. 223-227.
    
14. Flygaard R.K. Cryo-EM structure of the hibernating Thermus thermophilus 100S ribosome reveals a protein-mediated dimerization mechanism / R.K. Flygaard, N. Boegholm, M. Yusupov, L.B. Jenner// Nature Communications. - 2018. - V. 9. - Article number: 4179
15. Pellegrino S. Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance / S. Pellegrino, N. Demeshkina, E. Mancera-Martinez, S. Melnikov, A. Simonetti, A. Myasnikov, M. Yusupov, G. Yusupova, Y. Hashem // Journal of Molecular Biology. - 2018. - V. - 430. - P. 2677-2687.
16. Petrova O.A. Structure and function of the N-terminal domain of the yeast telomerase reverse trans­criptase / O.A. Petrova, A.B. Mantsyzov, E.V. Rodina, S.V. Efimov, C. Hackenberg, J. Hakanpää, V.V. Klochkov, A.A. Lebedev, A.A. Chugunova, A.N. Malyavko, T.S. Zatsepin, A.V. Mishin, M.I. Zvereva, V.S. Lamzin, O.A. Dontsova, V.I Polshakov // Nucleic Acids Research. - 2018. - V. 46. - P. 1525-1540
17. Usachev K. Simple Gd3+-Nue5NAc complexation enables asymmetrization of NMR chemical shifts of structurally equivalent complex-type N-glycan branches / K.Usachev, Takamatsu M., Pavlova N., Klochkov V., Yamaguchi Y., Kurbangalieva A., Tanaka K. // Analyst. – 2017. – V.142. – P. 2897-2900. 
18. Khusainov I. Structures and dynamics of hibernating ribosomes from Staphylococcus aureus mediated by intermolecular interactions of HPF / I.Khusainov, Q.Vicens, R.Ayupov, K.Usachev, A.Myasnikov, A.Simonetti, Sh.Validov, B.Kieffer, G.Yusupova, M.Yusupov, Y.Hashem // The EMBO journal. – 2017. –V. - 36. – P. 2073-2087.
19. Khusainov I. Structure of the 70S ribosome from human pathogen Staphylococcus aureus / I. Khusainov, Q. Vicens, A. Bochler , F. Grosse, A. Myasnikov, J.F. Menetret, J. Chicher, S. Marzi, P. Romby, G. Yusupova, M. Yusupov, Y. Hashem // Nucleic Acids Research. - 2016. - V. 44. - P. 10491-10504. 
20. Rozov A. Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code / A.Rozov, N.Demeshkina, I.Khusainov, E.Westhof, M.Yusupov, G.Yusupova // Nature Communications. - 2016. - V. 7. - Article number 10457

Патенты

Пат.2807690 Российская Федерация, Бесклеточная система синтеза белка на основе эмбриональных клеток Gallus gallus и способ синтеза белка на основе бесклеточной системы синтеза белка эмбриональных клеток / К.С. Усачев., А.А. Голубев, Н.М. Александрова, Э.А. Клочкова, А.Г. Бикмуллин, Ш.З. Валидов, М.М. Юсупов. – № 2022134547; заявл.27.12.2022