KFU. Card publication. Symptomatic Improvement, Increased Life-Span and Sustained Cell Homing in Amyotrophic Lateral Sclerosis After Transplantation of Human Umbilical Cord Blood Cells Genetically Modified with Adeno-Viral Vectors Expressing a Neuro-Protective Factor and a Neural Cell Adhesion Molecule

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SYMPTOMATIC IMPROVEMENT, INCREASED LIFE-SPAN AND SUSTAINED CELL HOMING IN AMYOTROPHIC LATERAL SCLEROSIS AFTER TRANSPLANTATION OF HUMAN UMBILICAL CORD BLOOD CELLS GENETICALLY MODIFIED WITH ADENO-VIRAL VECTORS EXPRESSING A NEURO-PROTECTIVE FACTOR AND A NEURAL CELL ADHESION MOLECULE

Form of presentation

Articles in international journals and collections

Year of publication

2015

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Authors, employees of KFU

Islamov Rustem Robertovich, author

Kiyasov Andrey Pavlovich, author

Mukhamedshina Yana Olegovna, author

Salafutdinov Ilnur Ildusovich, author

Soloveva Valeriya Vladimirovna, author

Authors, postgraduates KFU

Garanina Ekaterina Evgenevna, postgraduate kfu

Fedotova Valeriya Yurevna, postgraduate kfu

Bibliographic description in the original language

Islamov R.R. Symptomatic Improvement, Increased Life-Span and Sustained Cell Homing in Amyotrophic Lateral Sclerosis After Transplantation of Human Umbilical Cord Blood Cells Genetically Modified with Adeno-Viral Vectors Expressing a Neuro-Protective Factor and a Neural Cell Adhesion Molecule / R.R. Islamov, A.A. Rizvanov, M.A. Mukhamedyarov, I.I. Salafutdinov, E.E. Garanina, V.Y. Fedotova, V.V. Solovyeva, Y.O. Mukhamedshina, Z.Z. Safiullov, A.A. Izmailov, D.S. Guseva, A.L. Zefirov, A.P. Kiyasov, A. Palotás // Current Gene Therapy. - 2015. - Vol.15, Issue 2. - P.266-276.

Annotation

Amyotrophic lateral sclerosis (ALS) is an incurable, chronic, fatal neuro-degenerative disease characterized by progressive loss of moto-neurons and paralysis of skeletal muscles. Reactivating dysfunctional areas is under earnest investigation utilizing various approaches. Here we present an innovative gene-cell construct aimed at reviving inert structure and function. Human umbilical cord blood cells (hUCBCs) transduced with adeno-viral vectors encoding human VEGF, GDNF and/or NCAM genes were transplanted into transgenic ALS mice models. Significant improvement in behavioral performance (open-field and grip-strength tests), as well as increased life-span was observed in rodents treated with NCAM-VEGF or NCAM-GDNF co-transfected cells. Active trans-gene expression was found in the spinal cord of ALS mice 10 weeks after delivering genetically modified hUCBCs, and cells were detectable even 5 months following transplantation.

Keywords

Amyotrophic Lateral Sclerosis

The name of the journal

Current Gene Therapy

URL

http://www.ncbi.nlm.nih.gov/pubmed/25619885

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=98907&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Islamov Rustem Robertovich	ru_RU
dc.contributor.author	Kiyasov Andrey Pavlovich	ru_RU
dc.contributor.author	Mukhamedshina Yana Olegovna	ru_RU
dc.contributor.author	Salafutdinov Ilnur Ildusovich	ru_RU
dc.contributor.author	Soloveva Valeriya Vladimirovna	ru_RU
dc.contributor.author	Garanina Ekaterina Evgenevna	ru_RU
dc.contributor.author	Fedotova Valeriya Yurevna	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Islamov R.R. Symptomatic Improvement, Increased Life-Span and Sustained Cell Homing in Amyotrophic Lateral Sclerosis After Transplantation of Human Umbilical Cord Blood Cells Genetically Modified with Adeno-Viral Vectors Expressing a Neuro-Protective Factor and a Neural Cell Adhesion Molecule / R.R. Islamov, A.A. Rizvanov, M.A. Mukhamedyarov, I.I. Salafutdinov, E.E. Garanina, V.Y. Fedotova, V.V. Solovyeva, Y.O. Mukhamedshina, Z.Z. Safiullov, A.A. Izmailov, D.S. Guseva, A.L. Zefirov, A.P. Kiyasov, A. Palotás // Current Gene Therapy. - 2015. - Vol.15, Issue 2. - P.266-276.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=98907&p_lang=2	ru_RU
dc.description.abstract	Current Gene Therapy	ru_RU
dc.description.abstract	Amyotrophic lateral sclerosis (ALS) is an incurable, chronic, fatal neuro-degenerative disease characterized by progressive loss of moto-neurons and paralysis of skeletal muscles. Reactivating dysfunctional areas is under earnest investigation utilizing various approaches. Here we present an innovative gene-cell construct aimed at reviving inert structure and function. Human umbilical cord blood cells (hUCBCs) transduced with adeno-viral vectors encoding human VEGF, GDNF and/or NCAM genes were transplanted into transgenic ALS mice models. Significant improvement in behavioral performance (open-field and grip-strength tests), as well as increased life-span was observed in rodents treated with NCAM-VEGF or NCAM-GDNF co-transfected cells. Active trans-gene expression was found in the spinal cord of ALS mice 10 weeks after delivering genetically modified hUCBCs, and cells were detectable even 5 months following transplantation.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Symptomatic Improvement, Increased Life-Span and Sustained Cell Homing in Amyotrophic Lateral Sclerosis After Transplantation of Human Umbilical Cord Blood Cells Genetically Modified with Adeno-Viral Vectors Expressing a Neuro-Protective Factor and a Neural Cell Adhesion Molecule	ru_RU
dc.type	Articles in international journals and collections	ru_RU