KFU. Card publication. Ribonucleases as antiviral agents

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

RIBONUCLEASES AS ANTIVIRAL AGENTS

Form of presentation

Articles in Russian journals and collections

Year of publication

2014

Язык

русский

Authors, employees of KFU

Ilinskaya Olga Nikolaevna, author

Shakh Makhmud Raikhan , author

Bibliographic description in the original language

Ilinskaya O. N. Ribonucleases as antiviral agents / O. N. Ilinskaya, R. Shah Mahmud// Molecular biology. - 2014. - V. 48, I. 5. - P. 615-623.

Annotation

Many ribonucleases (RNases) are able to inhibit the reproduction of viruses in infected cell cultures and laboratory animals, but the molecular mechanisms of their antiviral activity remain unclear. The review dis- cusses the well-known RNases that possess established antiviral effects, including both intracellular RNases (RNase L, MCPIP1 protein, and eosinophil-associated RNases) and exogenous RNases (RNase A, BS-RNase, onconase, binase, and synthetic RNases). Attention is paid to two important, but not always obligatory, aspects of molecules of RNases that have antiviral properties, i.e., catalytic activity and ability to dimerize. The hypo- thetic scheme of virus elimination by exogenous RNases that reflects possible types of interaction of viruses and RNases with a cell is proposed. The evidence for RNases as classical components of immune defense and thus perspective agents for the development of new antiviral therapeutics is proposed.

Keywords

viruses, antiviral activity, RNase L, MCPIP1 protein, eosinophil-associated RNases, RNase A, BS-RNase, onconase, binase, synthetic RNase

The name of the journal

Молекулярная биология

URL

http://link.springer.com/article/10.1134%2FS0026893314040050

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=95713&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Ilinskaya Olga Nikolaevna	ru_RU
dc.contributor.author	Shakh Makhmud Raikhan	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Ilinskaya O. N. Ribonucleases as antiviral agents / O. N. Ilinskaya, R. Shah Mahmud// Molecular biology. - 2014. - V. 48, I. 5. - P. 615-623.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=95713&p_lang=2	ru_RU
dc.description.abstract	Молекулярная биология	ru_RU
dc.description.abstract	Many ribonucleases (RNases) are able to inhibit the reproduction of viruses in infected cell cultures and laboratory animals, but the molecular mechanisms of their antiviral activity remain unclear. The review dis- cusses the well-known RNases that possess established antiviral effects, including both intracellular RNases (RNase L, MCPIP1 protein, and eosinophil-associated RNases) and exogenous RNases (RNase A, BS-RNase, onconase, binase, and synthetic RNases). Attention is paid to two important, but not always obligatory, aspects of molecules of RNases that have antiviral properties, i.e., catalytic activity and ability to dimerize. The hypo- thetic scheme of virus elimination by exogenous RNases that reflects possible types of interaction of viruses and RNases with a cell is proposed. The evidence for RNases as classical components of immune defense and thus perspective agents for the development of new antiviral therapeutics is proposed.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	viruses	ru_RU
dc.subject	antiviral activity	ru_RU
dc.subject	RNase L	ru_RU
dc.subject	MCPIP1 protein	ru_RU
dc.subject	eosinophil-associated RNases	ru_RU
dc.subject	RNase A	ru_RU
dc.subject	BS-RNase	ru_RU
dc.subject	onconase	ru_RU
dc.subject	binase	ru_RU
dc.subject	synthetic RNase	ru_RU
dc.title	Ribonucleases as antiviral agents	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU