KFU. Card publication. Chemical Glycan Conjugation Controls the Biodistribution and Kinetics of Proteins in Live Animals

KAZAN
FEDERAL UNIVERSITY

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CHEMICAL GLYCAN CONJUGATION CONTROLS THE BIODISTRIBUTION AND KINETICS OF PROTEINS IN LIVE ANIMALS

Form of presentation

Articles in international journals and collections

Year of publication

2014

Authors, employees of KFU

Kurbangalieva Almira Rafaelovna, author

Other authors

A. Ogura

Bibliographic description in the original language

A. Ogura, A. Kurbangalieva, K. Tanaka. Chemical Glycan Conjugation Controls the Biodistribution and Kinetics of Proteins in Live Animals // Mini-Rev. Med. Chem. 2014. V. 14. � 13. P. 1072–1077.

Annotation

The biodistributions and in vivo kinetics of chemically prepared neoglycoproteins have been examined previously and are reviewed here. A variety of mono- and oligosaccharides may be conjugated onto a protein surface using chemical methods. The kinetics and organ-specific accumulation profiles of these glycoconjugates, introduced through intravenous injection, have been analyzed using conventional dissection studies as well as noninvasive methods, such as SPECT, PET, or fluorescence imaging. These studies have revealed glycan-dependent protein distribution kinetics that may be useful for pharmacological and diagnostic applications.

Keywords

Albumin, bioconjugation, biodistribution, chemical reaction, in vivo imaging, neoglycoprotein, N-glycans, tumor targeting.

The name of the journal

MINI-REV MEDCHEM

URL

http://benthamscience.com/journal/abstracts.php?journalID=mrmc&articleID=126443

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=94721&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kurbangalieva Almira Rafaelovna	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	A. Ogura, A. Kurbangalieva, K. Tanaka. Chemical Glycan Conjugation Controls the Biodistribution and Kinetics of Proteins in Live Animals // Mini-Rev. Med. Chem. 2014. V. 14. � 13. P. 1072–1077.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=94721&p_lang=2	ru_RU
dc.description.abstract	MINI-REV MEDCHEM	ru_RU
dc.description.abstract	The biodistributions and in vivo kinetics of chemically prepared neoglycoproteins have been examined previously and are reviewed here. A variety of mono- and oligosaccharides may be conjugated onto a protein surface using chemical methods. The kinetics and organ-specific accumulation profiles of these glycoconjugates, introduced through intravenous injection, have been analyzed using conventional dissection studies as well as noninvasive methods, such as SPECT, PET, or fluorescence imaging. These studies have revealed glycan-dependent protein distribution kinetics that may be useful for pharmacological and diagnostic applications.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Albumin	ru_RU
dc.subject	bioconjugation	ru_RU
dc.subject	biodistribution	ru_RU
dc.subject	chemical reaction	ru_RU
dc.subject	in vivo imaging	ru_RU
dc.subject	neoglycoprotein	ru_RU
dc.subject	N-glycans	ru_RU
dc.subject	tumor targeting.	ru_RU
dc.title	Chemical Glycan Conjugation Controls the Biodistribution and Kinetics of Proteins in Live Animals	ru_RU
dc.type	Articles in international journals and collections	ru_RU