KFU. Card publication. Plasmacytoid dendritic cells in the duodenum of individuals diagnosed with myalgic encephalomyelitis are uniquely immunoreactive to antibodies to human endogenous retroviral proteins

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PLASMACYTOID DENDRITIC CELLS IN THE DUODENUM OF INDIVIDUALS DIAGNOSED WITH MYALGIC ENCEPHALOMYELITIS ARE UNIQUELY IMMUNOREACTIVE TO ANTIBODIES TO HUMAN ENDOGENOUS RETROVIRAL PROTEINS

Form of presentation

Articles in international journals and collections

Year of publication

2013

Authors, employees of KFU

Lombardi Vinsent Klifford , author

Rizvanov Albert Anatolevich, author

Khaybullina Svetlana Francevna, author

Other authors

K.L. De Meirleir; M. Frémont; J. Hulstaert; A. Palotás

Bibliographic description in the original language

De Meirleir K.L. Plasmacytoid dendritic cells in the duodenum of individuals diagnosed with myalgic encephalomyelitis are uniquely immunoreactive to antibodies to human endogenous retroviral proteins / K.L. De Meirleir, S.F. Khaiboullina, M. Frémont, J. Hulstaert, A.A. Rizvanov, A. Palotás, V.C. Lombardi // IN VIVO. – 2013. – Vol.27, No.2. – P.177-187.

Annotation

Myalgic encephalomyelitis (ME) is a debilitating illness of unknown etiology characterized by neurocognitive dysfunction, inflammation, immune abnormalities and gastrointestinal distress. An increasing body of evidence suggests that disruptions in the gut may contribute to the induction of neuroinflammation. Therefore, reports of human endogenous retroviral (HERV) expression in association with neuroinflammatory diseases prompted us to investigate the gut of individuals with ME for the presence of HERV proteins. In eight out of 12 individuals with ME, immunoreactivity to HERV proteins was observed in duodenal biopsies. In contrast, no immunoreactivity was detected in any of the eight controls. Immunoreactivity to HERV Gag and Env proteins was uniquely co-localized in hematopoietic cells expressing the C-type lectin receptor CLEC4C (CD303/BDCA2), the co-stimulatory marker CD86 and the class II major histocompatibility complex HLA-DR, consistent with plasmacytoid dendritic cells (pDCs).

Keywords

Myalgic encephalomyelitis, ME, human endogenous retrovirus, HERV, plasmacytoid dendritic cell, pDC

The name of the journal

IN VIVO

URL

http://www.ncbi.nlm.nih.gov/pubmed/23422476

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=94169&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Lombardi Vinsent Klifford	ru_RU
dc.contributor.author	Rizvanov Albert Anatolevich	ru_RU
dc.contributor.author	Khaybullina Svetlana Francevna	ru_RU
dc.date.accessioned	2013-01-01T00:00:00Z	ru_RU
dc.date.available	2013-01-01T00:00:00Z	ru_RU
dc.date.issued	2013	ru_RU
dc.identifier.citation	De Meirleir K.L. Plasmacytoid dendritic cells in the duodenum of individuals diagnosed with myalgic encephalomyelitis are uniquely immunoreactive to antibodies to human endogenous retroviral proteins / K.L. De Meirleir, S.F. Khaiboullina, M. Frémont, J. Hulstaert, A.A. Rizvanov, A. Palotás, V.C. Lombardi // IN VIVO. – 2013. – Vol.27, No.2. – P.177-187.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=94169&p_lang=2	ru_RU
dc.description.abstract	IN VIVO	ru_RU
dc.description.abstract	Myalgic encephalomyelitis (ME) is a debilitating illness of unknown etiology characterized by neurocognitive dysfunction, inflammation, immune abnormalities and gastrointestinal distress. An increasing body of evidence suggests that disruptions in the gut may contribute to the induction of neuroinflammation. Therefore, reports of human endogenous retroviral (HERV) expression in association with neuroinflammatory diseases prompted us to investigate the gut of individuals with ME for the presence of HERV proteins. In eight out of 12 individuals with ME, immunoreactivity to HERV proteins was observed in duodenal biopsies. In contrast, no immunoreactivity was detected in any of the eight controls. Immunoreactivity to HERV Gag and Env proteins was uniquely co-localized in hematopoietic cells expressing the C-type lectin receptor CLEC4C (CD303/BDCA2), the co-stimulatory marker CD86 and the class II major histocompatibility complex HLA-DR, consistent with plasmacytoid dendritic cells (pDCs).	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Myalgic encephalomyelitis	ru_RU
dc.subject	ME	ru_RU
dc.subject	human endogenous retrovirus	ru_RU
dc.subject	HERV	ru_RU
dc.subject	plasmacytoid dendritic cell	ru_RU
dc.subject	pDC	ru_RU
dc.title	Plasmacytoid dendritic cells in the duodenum of individuals diagnosed with myalgic encephalomyelitis are uniquely immunoreactive to antibodies to human endogenous retroviral proteins	ru_RU
dc.type	Articles in international journals and collections	ru_RU