KFU. Card publication. Andes-virus-induced cytokine storm is partially suppressed by Ribavirin

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

ANDES-VIRUS-INDUCED CYTOKINE STORM IS PARTIALLY SUPPRESSED BY RIBAVIRIN

Form of presentation

Articles in international journals and collections

Year of publication

2013

Authors, employees of KFU

Lombardi Vinsent Klifford , author

Rizvanov Albert Anatolevich, author

Khaybullina Svetlana Francevna, author

Other authors

S.P. Morzunov; H.J. Reis; A. Palotás; S. Jeor

Bibliographic description in the original language

Khaiboullina S.F. Andes-virus-induced cytokine storm is partially suppressed by Ribavirin / S.F. Khaiboullina, A.A. Rizvanov, V.C. Lombardi, S.P. Morzunov, H.J. Reis, A. Palotás, S. Jeor // Antiviral Therapy. – 2013. – Vol.18, No.4. – P.575-584.

Annotation

Microbe-induced over-activation of cytokines, especially tumour necrosis factor (TNF)-α, is key to the pathogenesis of hantavirus infection leading to severe inflammation with high mortality rate. Although ribavirin showed promise in inhibiting viral replication in vitro, its clinical efficacy remains controversial. Ribavirin decreased the virus load and dose-dependently inhibited the accumulation of RANTES messenger RNA in Andes-virus (ANDV)-infected human endothelial cells, but failed to suppress TNF-α-induced activation of RANTES and interleukin-6 in ANDV-inoculated cultures. This report also shows, for the first time, that the deleterious over-stimulation by TNF-α is mediated by nuclear factor-κB, and describes the effect of ribavirin on cytokine production following ANDV infection.

Keywords

Cytokines, Ribavirin, Andes-virus

The name of the journal

ANTIVIR THER

URL

http://www.ncbi.nlm.nih.gov/pubmed/23300158

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=94166&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Lombardi Vinsent Klifford	ru_RU
dc.contributor.author	Rizvanov Albert Anatolevich	ru_RU
dc.contributor.author	Khaybullina Svetlana Francevna	ru_RU
dc.date.accessioned	2013-01-01T00:00:00Z	ru_RU
dc.date.available	2013-01-01T00:00:00Z	ru_RU
dc.date.issued	2013	ru_RU
dc.identifier.citation	Khaiboullina S.F. Andes-virus-induced cytokine storm is partially suppressed by Ribavirin / S.F. Khaiboullina, A.A. Rizvanov, V.C. Lombardi, S.P. Morzunov, H.J. Reis, A. Palotás, S. Jeor // Antiviral Therapy. – 2013. – Vol.18, No.4. – P.575-584.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=94166&p_lang=2	ru_RU
dc.description.abstract	ANTIVIR THER	ru_RU
dc.description.abstract	Microbe-induced over-activation of cytokines, especially tumour necrosis factor (TNF)-α, is key to the pathogenesis of hantavirus infection leading to severe inflammation with high mortality rate. Although ribavirin showed promise in inhibiting viral replication in vitro, its clinical efficacy remains controversial. Ribavirin decreased the virus load and dose-dependently inhibited the accumulation of RANTES messenger RNA in Andes-virus (ANDV)-infected human endothelial cells, but failed to suppress TNF-α-induced activation of RANTES and interleukin-6 in ANDV-inoculated cultures. This report also shows, for the first time, that the deleterious over-stimulation by TNF-α is mediated by nuclear factor-κB, and describes the effect of ribavirin on cytokine production following ANDV infection.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Cytokines	ru_RU
dc.subject	Ribavirin	ru_RU
dc.subject	Andes-virus	ru_RU
dc.title	Andes-virus-induced cytokine storm is partially suppressed by Ribavirin	ru_RU
dc.type	Articles in international journals and collections	ru_RU