KFU. Card publication. Effects of Transplantation of Human Cord Blood Mononuclear Cells Expressing the Recombinant VEGF and FGF2 Genes into Spinal Cord Traumatic Injury Sites in Rats

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EFFECTS OF TRANSPLANTATION OF HUMAN CORD BLOOD MONONUCLEAR CELLS EXPRESSING THE RECOMBINANT VEGF AND FGF2 GENES INTO SPINAL CORD TRAUMATIC INJURY SITES IN RATS

Form of presentation

Articles in international journals and collections

Year of publication

2013

Authors, employees of KFU

Mukhamedshina Yana Olegovna, author

Rizvanov Albert Anatolevich, author

Salafutdinov Ilnur Ildusovich, author

Other authors

G.F. Shaimardanova; Yu.A. Chelyshev

Bibliographic description in the original language

Shaimardanova G.F. Effects of Transplantation of Human Cord Blood Mononuclear Cells Expressing the Recombinant VEGF and FGF2 Genes into Spinal Cord Traumatic Injury Sites in Rats / G.F. Shaimardanova, Ya.O. Mukhamedshina, A.A. Rizvanov, I.I. Salafutdinov, Yu.A. Chelyshev // Neuroscience and Behavioral Physiology. – 2013. – Vol.43, No.5. – P.597-601.

Annotation

A model of dosed TVIII spinal cord contusion trauma in rats was used to study the effects of immediate single-dose transplantation of human cord blood mononuclear cells transformed with the recombinant genes for neurotrophic factors ? vascular endothelia growth factor (VEGF) and fibroblast growth factor 2 (FGF2) ? into the injury zone. A further group of animals, in the same conditions, received the same cells transfected with plasmid pEGFP-N2. EGFP-labeled cells were detected in the white matter for 21 days after transplantation at distances of at least 10 mm in the rostral and caudal directions from the administration point. By 30 days after transplantation with cells transfected with plasmid pBud-VEGF-FGF2, the area of intact gray matter 3 mm from the trauma epicenter increased by more than 60%.

Keywords

spinal cord, regeneration, cord blood cells, VEGF, FGF2

The name of the journal

Neuroscience and Behavioral Physiology

URL

http://download.springer.com/static/pdf/302/art%253A10.1007%252Fs11055-013-9778-0.pdf?auth66=1418904581_6b9e8dafa09e22d6a8916cf1a4d71167&ext=.pdf

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=94161&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Mukhamedshina Yana Olegovna	ru_RU
dc.contributor.author	Rizvanov Albert Anatolevich	ru_RU
dc.contributor.author	Salafutdinov Ilnur Ildusovich	ru_RU
dc.date.accessioned	2013-01-01T00:00:00Z	ru_RU
dc.date.available	2013-01-01T00:00:00Z	ru_RU
dc.date.issued	2013	ru_RU
dc.identifier.citation	Shaimardanova G.F. Effects of Transplantation of Human Cord Blood Mononuclear Cells Expressing the Recombinant VEGF and FGF2 Genes into Spinal Cord Traumatic Injury Sites in Rats / G.F. Shaimardanova, Ya.O. Mukhamedshina, A.A. Rizvanov, I.I. Salafutdinov, Yu.A. Chelyshev // Neuroscience and Behavioral Physiology. – 2013. – Vol.43, No.5. – P.597-601.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=94161&p_lang=2	ru_RU
dc.description.abstract	Neuroscience and Behavioral Physiology	ru_RU
dc.description.abstract	A model of dosed TVIII spinal cord contusion trauma in rats was used to study the effects of immediate single-dose transplantation of human cord blood mononuclear cells transformed with the recombinant genes for neurotrophic factors ? vascular endothelia growth factor (VEGF) and fibroblast growth factor 2 (FGF2) ? into the injury zone. A further group of animals, in the same conditions, received the same cells transfected with plasmid pEGFP-N2. EGFP-labeled cells were detected in the white matter for 21 days after transplantation at distances of at least 10 mm in the rostral and caudal directions from the administration point. By 30 days after transplantation with cells transfected with plasmid pBud-VEGF-FGF2, the area of intact gray matter 3 mm from the trauma epicenter increased by more than 60%.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	spinal cord	ru_RU
dc.subject	regeneration	ru_RU
dc.subject	cord blood cells	ru_RU
dc.subject	VEGF	ru_RU
dc.subject	FGF2	ru_RU
dc.title	Effects of Transplantation of Human Cord Blood Mononuclear Cells Expressing the Recombinant VEGF and FGF2 Genes into Spinal Cord Traumatic Injury Sites in Rats	ru_RU
dc.type	Articles in international journals and collections	ru_RU