KFU. Card publication. Analysis of the efficiency of gene-cell therapy in transgenic mice with amyotrophic lateral sclerosis phenotype

KAZAN
FEDERAL UNIVERSITY

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ANALYSIS OF THE EFFICIENCY OF GENE-CELL THERAPY IN TRANSGENIC MICE WITH AMYOTROPHIC LATERAL SCLEROSIS PHENOTYPE

Form of presentation

Articles in international journals and collections

Year of publication

2013

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Authors, employees of KFU

Abdulkhakov Sayyar Rustamovich, author

Garanina Ekaterina Evgenevna, author

Kaligin Maksim Sergeevich, author

Kiyasov Andrey Pavlovich, author

Rizvanov Albert Anatolevich, author

Salafutdinov Ilnur Ildusovich, author

Soloveva Valeriya Vladimirovna, author

Authors, postgraduates KFU

Garanina Ekaterina Evgenevna, postgraduate kfu

Fedotova Valeriya Yurevna, postgraduate kfu

Bibliographic description in the original language

Mukhamedyarov M.A. Analysis of the efficiency of gene-cell therapy in transgenic mice with amyotrophic lateral sclerosis phenotype / M.A. Mukhamedyarov, A.A. Rizvanov, Z.Z. Safiullov, A.A. Izmailov, G.A. Sharifullina, V.V. Solovieva, V.Yu. Fedotova, I.I. Salafutdinov, E.E. Cherenkova, F.V. Bashirov, M.S. Kaligin, S.R. Abdulkhakov, M.M. Shmarov, D.Yu. Logunov, B.S. Naroditsky, A.P. Kiyasov, A.L. Zefirov, R.R. Islamov // Bulletin of Experimental Biology and Medicine. - Vol.154, �4. - P.558-561.

Annotation

Amyotrophic lateral sclerosis is a neurodegenerative disease characterized by progressive death of cerebral and spinal motorneurons. Using behavioral tests we studied the efficiency of gene-cell therapy in SOD1 G93A transgenic mice receiving xenotransplantation of human umbilical cord blood mononuclear cells genetically modified with adenoviral vectors encoding vascular endothelial growth factor (VEGF) and reporter green fluorescent protein (EGFP) genes. The cells were transplanted to mice on week 27 of life (preclinical stage of the disease). Behavioral tests (open field, grip strength test) showed that transplantation of umbilical cord blood mononuclear cells expressing VEGF significantly improved the parameters of motor and explorative activity, grip strength, and animal survival. Thus, gene-cell therapy based on genetically modified mononuclear cells expressing VEGF can be efficient for the treatment of amyotrophic lateral sclerosis.

Keywords

amyotrophic lateral sclerosis, gene-cell therapy, SOD1-G93A, transgenic mice, vascular endothelial growth factor, human umbilical cord blood mononuclear cells

The name of the journal

Bulletin of Experimental Biology and Medicine

URL

http://www.ncbi.nlm.nih.gov/pubmed/23486603http://www.ncbi.nlm.nih.gov/pubmed/23486603

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=94048&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Abdulkhakov Sayyar Rustamovich	ru_RU
dc.contributor.author	Garanina Ekaterina Evgenevna	ru_RU
dc.contributor.author	Kaligin Maksim Sergeevich	ru_RU
dc.contributor.author	Kiyasov Andrey Pavlovich	ru_RU
dc.contributor.author	Rizvanov Albert Anatolevich	ru_RU
dc.contributor.author	Salafutdinov Ilnur Ildusovich	ru_RU
dc.contributor.author	Soloveva Valeriya Vladimirovna	ru_RU
dc.contributor.author	Garanina Ekaterina Evgenevna	ru_RU
dc.contributor.author	Fedotova Valeriya Yurevna	ru_RU
dc.date.accessioned	2013-01-01T00:00:00Z	ru_RU
dc.date.available	2013-01-01T00:00:00Z	ru_RU
dc.date.issued	2013	ru_RU
dc.identifier.citation	Mukhamedyarov M.A. Analysis of the efficiency of gene-cell therapy in transgenic mice with amyotrophic lateral sclerosis phenotype / M.A. Mukhamedyarov, A.A. Rizvanov, Z.Z. Safiullov, A.A. Izmailov, G.A. Sharifullina, V.V. Solovieva, V.Yu. Fedotova, I.I. Salafutdinov, E.E. Cherenkova, F.V. Bashirov, M.S. Kaligin, S.R. Abdulkhakov, M.M. Shmarov, D.Yu. Logunov, B.S. Naroditsky, A.P. Kiyasov, A.L. Zefirov, R.R. Islamov // Bulletin of Experimental Biology and Medicine. - Vol.154, �4. - P.558-561.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=94048&p_lang=2	ru_RU
dc.description.abstract	Bulletin of Experimental Biology and Medicine	ru_RU
dc.description.abstract	Amyotrophic lateral sclerosis is a neurodegenerative disease characterized by progressive death of cerebral and spinal motorneurons. Using behavioral tests we studied the efficiency of gene-cell therapy in SOD1 G93A transgenic mice receiving xenotransplantation of human umbilical cord blood mononuclear cells genetically modified with adenoviral vectors encoding vascular endothelial growth factor (VEGF) and reporter green fluorescent protein (EGFP) genes. The cells were transplanted to mice on week 27 of life (preclinical stage of the disease). Behavioral tests (open field, grip strength test) showed that transplantation of umbilical cord blood mononuclear cells expressing VEGF significantly improved the parameters of motor and explorative activity, grip strength, and animal survival. Thus, gene-cell therapy based on genetically modified mononuclear cells expressing VEGF can be efficient for the treatment of amyotrophic lateral sclerosis.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	amyotrophic lateral sclerosis	ru_RU
dc.subject	gene-cell therapy	ru_RU
dc.subject	SOD1-G93A	ru_RU
dc.subject	transgenic mice	ru_RU
dc.subject	vascular endothelial growth factor	ru_RU
dc.subject	human umbilical cord blood mononuclear cells	ru_RU
dc.title	Analysis of the efficiency of gene-cell therapy in transgenic mice with amyotrophic lateral sclerosis phenotype	ru_RU
dc.type	Articles in international journals and collections	ru_RU