KFU. Card publication. Human dendritic cells transfected with a human papilloma virus-18 construct display decreased mobility and upregulated cytokine production

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HUMAN DENDRITIC CELLS TRANSFECTED WITH A HUMAN PAPILLOMA VIRUS-18 CONSTRUCT DISPLAY DECREASED MOBILITY AND UPREGULATED CYTOKINE PRODUCTION

Form of presentation

Articles in international journals and collections

Year of publication

2013

Authors, employees of KFU

Lombardi Vinsent Klifford , author

Rizvanov Albert Anatolevich, author

Khaybullina Svetlana Francevna, author

Other authors

S.P. Morzunov; M.R. Hall; K.L. De Meirleir

Bibliographic description in the original language

Khaiboullina S.F. Human dendritic cells transfected with a human papilloma virus-18 construct display decreased mobility and upregulated cytokine production / S.F. Khaiboullina, S.P. Morzunov, M.R. Hall, K.L. De Meirleir, A.A. Rizvanov and V.C. Lombardi // International Journal of Oncology. – 2013. – Vol. 43, No.5. – P.1701-1709.

Annotation

International Journal of Oncology

Keywords

Human dendritic cells

The name of the journal

International Journal of Oncology

URL

http://www.ncbi.nlm.nih.gov/pubmed/23969559

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=93707&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Lombardi Vinsent Klifford	ru_RU
dc.contributor.author	Rizvanov Albert Anatolevich	ru_RU
dc.contributor.author	Khaybullina Svetlana Francevna	ru_RU
dc.date.accessioned	2013-01-01T00:00:00Z	ru_RU
dc.date.available	2013-01-01T00:00:00Z	ru_RU
dc.date.issued	2013	ru_RU
dc.identifier.citation	Khaiboullina S.F. Human dendritic cells transfected with a human papilloma virus-18 construct display decreased mobility and upregulated cytokine production / S.F. Khaiboullina, S.P. Morzunov, M.R. Hall, K.L. De Meirleir, A.A. Rizvanov and V.C. Lombardi // International Journal of Oncology. – 2013. – Vol. 43, No.5. – P.1701-1709.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=93707&p_lang=2	ru_RU
dc.description.abstract	International Journal of Oncology	ru_RU
dc.description.abstract	The marked depletion of dendritic cells (DCs) in skin cancers, as well as preneoplastic and neoplastic cervical epithelium, suggests a central role for DCs in productive human papillomavirus (HPV) infection and cancer promotion. It has been suggested that HPV may facilitate tumor development by reducing DC density, contributing to a decrease in local immune surveillance. In this study, we have examined the response of human DCs transfected with a construct containing the HPV18 genome and their subsequent expression of papilloma virus proteins. Transfected cells expressed the L1 major capsid protein and upregulated E6 and E7 oncoprotein transcripts as detected by RT-PCR. Transfection of DCs also resulted in a significant increase in cytokine production. Finally, we observed that HPV18 transfection decreased the migratory activity of DCs.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Human dendritic cells transfected with a human papilloma virus-18 construct display decreased mobility and upregulated cytokine production	ru_RU
dc.type	Articles in international journals and collections	ru_RU