KFU. Card publication. Upregulation of IFN-γ and IL-12 is associated with a milder form of hantavirus hemorrhagic fever with renal syndrome

KAZAN
FEDERAL UNIVERSITY

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UPREGULATION OF IFN-γ AND IL-12 IS ASSOCIATED WITH A MILDER FORM OF HANTAVIRUS HEMORRHAGIC FEVER WITH RENAL SYNDROME

Form of presentation

Articles in international journals and collections

Year of publication

2014

Authors, employees of KFU

Lombardi Vinsent Klifford , author

Martynova Ekaterina Vladimirovna, author

Khaybullina Svetlana Francevna, author

Other authors

Z.L. Khamidullina; E.V. Lapteva; I.V. Nikolaeva; V.V. Anokhin

Bibliographic description in the original language

Khaiboullina S.F. Upregulation of IFN-γ and IL-12 is associated with a milder form of hantavirus hemorrhagic fever with renal syndrome / S.F. Khaiboullina, E.V. Martynova, Z.L. Khamidullina, E.V. Lapteva, I.V. Nikolaeva, V.V. Anokhin, V.C. Lombardi, A.A. Rizvanov // European Journal of Clinical Microbiology & Infectious Diseases. – 2014. – Vol.33, Issue 12. - P.2149-56.

Annotation

Eur J Clin Microbiol Infect Dis

Keywords

Hantavirus, Hantavirus hemorrhagic fever with renal syndrome, cytokines

The name of the journal

Eur J Clin Microbiol Infect Dis

URL

http://www.ncbi.nlm.nih.gov/pubmed/24942310

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=93694&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Lombardi Vinsent Klifford	ru_RU
dc.contributor.author	Martynova Ekaterina Vladimirovna	ru_RU
dc.contributor.author	Khaybullina Svetlana Francevna	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Khaiboullina S.F. Upregulation of IFN-γ and IL-12 is associated with a milder form of hantavirus hemorrhagic fever with renal syndrome / S.F. Khaiboullina, E.V. Martynova, Z.L. Khamidullina, E.V. Lapteva, I.V. Nikolaeva, V.V. Anokhin, V.C. Lombardi, A.A. Rizvanov // European Journal of Clinical Microbiology & Infectious Diseases. – 2014. – Vol.33, Issue 12. - P.2149-56.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=93694&p_lang=2	ru_RU
dc.description.abstract	Eur J Clin Microbiol Infect Dis	ru_RU
dc.description.abstract	Hantavirus hemorrhagic fever with renal syndrome (HFRS) is a zoonotic disease characterized by acute onset, fever, malaise, and back pain. As the disease progresses, hemorrhagic disturbances and kidney dysfunctions predominate. The examination of tissue collected postmortem supports the premise that virus replication is not responsible for this pathology; therefore, it is widely believed that virus-induced immune responses lead to the clinical manifestations associated with HFRS. The overproduction of inflammatory cytokines is commonly reported in subjects with HFRS and has given rise to the hypothesis that a so-called "cytokine storm" may play a pivotal role in the pathogenesis of this disease. Currently, supportive care remains the only effective treatment for HFRS. Our data show that serum levels of interferon (IFN)-γ, interleukin (IL)-10, CCL2, and IL-12 are upregulated in HFRS cases when compared to healthy controls and the level of upregulation is dependent on the phase and sever	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Hantavirus	ru_RU
dc.subject	Hantavirus hemorrhagic fever with renal syndrome	ru_RU
dc.subject	cytokines	ru_RU
dc.title	Upregulation of IFN-γ and IL-12 is associated with a milder form of hantavirus hemorrhagic fever with renal syndrome	ru_RU
dc.type	Articles in international journals and collections	ru_RU