KFU. Card publication. Inflammatory cytokines kinetics define the severity and phase of nephropathia epidemica

KAZAN
FEDERAL UNIVERSITY

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INFLAMMATORY CYTOKINES KINETICS DEFINE THE SEVERITY AND PHASE OF NEPHROPATHIA EPIDEMICA

Form of presentation

Articles in international journals and collections

Year of publication

2014

Authors, employees of KFU

Lombardi Vinsent Klifford , author

Martynova Ekaterina Vladimirovna, author

Khaybullina Svetlana Francevna, author

Other authors

A.A. Baigildina; V.A. Anokhin

Bibliographic description in the original language

Baigildina A.A. Inflammatory cytokines kinetics define the severity and phase of nephropathia epidemica / A.A. Baigildina, S.F. Khaiboullina, E.V. Martynova, V.A. Anokhin, V.C. Lombardi, A.A. Rizvanov // Biomarkers in Medicine. – 2014. – doi:10.2217/bmm.14.88.

Annotation

Biomarkers in Medicine

Keywords

HRFS, Hantavirus, Puumala virus, cytokine, nephropathia epidemica

The name of the journal

Biomarkers in Medicine

URL

http://www.futuremedicine.com/doi/abs/10.2217/bmm.14.88?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=93692&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Lombardi Vinsent Klifford	ru_RU
dc.contributor.author	Martynova Ekaterina Vladimirovna	ru_RU
dc.contributor.author	Khaybullina Svetlana Francevna	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Baigildina A.A. Inflammatory cytokines kinetics define the severity and phase of nephropathia epidemica / A.A. Baigildina, S.F. Khaiboullina, E.V. Martynova, V.A. Anokhin, V.C. Lombardi, A.A. Rizvanov // Biomarkers in Medicine. – 2014. – doi:10.2217/bmm.14.88.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=93692&p_lang=2	ru_RU
dc.description.abstract	Biomarkers in Medicine	ru_RU
dc.description.abstract	Aims: Nephropathia epidemica (NE) is a form of hemorrhagic fever with renal syndrome associated with the Puumala virus species of Hantavirus. The pathogenesis of NE is not well understood; therefore, investigating the inflammatory cytokine response to infection may provide useful knowledge in deciphering the pathophysiology of NE. Materials & methods: Using Luminex and ELISA, we analyzed the serum of 137 NE cases and 44 controls to investigate if serum cytokines associate with different clinical presentations. Results: Serum levels of TNF-α and IL-1β are associated with disease severity while upregulation of IL-6, CXCL10, CCL2 and CCL3 are associated with clinical presentation. Conclusion: Inflammatory cytokine kinetics associate with the severity and phase of NE. Our data support a role for inflammatory cytokines in the pathophysiology of NE.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	HRFS	ru_RU
dc.subject	Hantavirus	ru_RU
dc.subject	Puumala virus	ru_RU
dc.subject	cytokine	ru_RU
dc.subject	nephropathia epidemica	ru_RU
dc.title	Inflammatory cytokines kinetics define the severity and phase of nephropathia epidemica	ru_RU
dc.type	Articles in international journals and collections	ru_RU