KFU. Card publication. Over-expression of oct4 and sox2 transcription factors enhances differentiation of human umbilical cord blood cells in vivo

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OVER-EXPRESSION OF OCT4 AND SOX2 TRANS&SHY;CRIPTION FACTORS ENHANCES DIFFERENTIATION OF HUMAN UMBILICAL CORD BLOOD CELLS IN VIVO

Form of presentation

Articles in international journals and collections

Year of publication

2014

Authors, employees of KFU

Salafutdinov Ilnur Ildusovich, author

Other authors

D. Guseva; A. Palotás; R.R. Islamov

Authors, postgraduates KFU

Kudryashova Nezhdana Vladimirovna, postgraduate kfu

Bibliographic description in the original language

Guseva D. Over-expression of oct4 and sox2 transcription factors enhances differentiation of human umbilical cord blood cells in vivo / D. Guseva, A.A. Rizvanov, I.I. Salafutdinov, N.V. Kudryashova, A. Palotás, R.R. Islamov // Biochem Biophys Res Commun. - 2014. - Vol.451, Issue 4. - P.503-509.

Annotation

Gene and cell-based therapies comprise innovative aspects of regenerative medicine. Even though stem cells represent a highly potential therapeutic strategy, their wide-spread exploitation is marred by ethical concerns, potential for malignant transformation and a plethora of other technical issues, largely restricting their use to experimental studies. Utilizing genetically modified human umbilical cord blood mono-nuclear cells (hUCB-MCs), this communication reports enhanced differentiation of transplants in a mouse model of amyotrophic lateral sclerosis (ALS). Over-expressing Oct4 and Sox2 induced production of neural marker PGP9.5, as well as transformation of hUCB-MCs into micro-glial and endothelial lines in ALS spinal cords. In addition to producing new nerve cells, providing degenerated areas with trophic factors and neo-vascularisation might prevent and even reverse progressive loss of moto-neurons and skeletal muscle paralysis.

Keywords

Amyotrophic lateral sclerosis, Differentiation, Umbilical cord blood mono-nuclear cell, Pluripotency, Transcription factor

The name of the journal

BIOCHEM BIOPH RES CO

URL

http://www.sciencedirect.com/science/article/pii/S0006291X14013953

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=93686&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Salafutdinov Ilnur Ildusovich	ru_RU
dc.contributor.author	Kudryashova Nezhdana Vladimirovna	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Guseva D. Over-expression of oct4 and sox2 transcription factors enhances differentiation of human umbilical cord blood cells in vivo / D. Guseva, A.A. Rizvanov, I.I. Salafutdinov, N.V. Kudryashova, A. Palotás, R.R. Islamov // Biochem Biophys Res Commun. - 2014. - Vol.451, Issue 4. - P.503-509.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=93686&p_lang=2	ru_RU
dc.description.abstract	BIOCHEM BIOPH RES CO	ru_RU
dc.description.abstract	Gene and cell-based therapies comprise innovative aspects of regenerative medicine. Even though stem cells represent a highly potential therapeutic strategy, their wide-spread exploitation is marred by ethical concerns, potential for malignant transformation and a plethora of other technical issues, largely restricting their use to experimental studies. Utilizing genetically modified human umbilical cord blood mono-nuclear cells (hUCB-MCs), this communication reports enhanced differentiation of transplants in a mouse model of amyotrophic lateral sclerosis (ALS). Over-expressing Oct4 and Sox2 induced production of neural marker PGP9.5, as well as transformation of hUCB-MCs into micro-glial and endothelial lines in ALS spinal cords. In addition to producing new nerve cells, providing degenerated areas with trophic factors and neo-vascularisation might prevent and even reverse progressive loss of moto-neurons and skeletal muscle paralysis.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Amyotrophic lateral sclerosis	ru_RU
dc.subject	Differentiation	ru_RU
dc.subject	Umbilical cord blood mono-nuclear cell	ru_RU
dc.subject	Pluripotency	ru_RU
dc.subject	Transcription factor	ru_RU
dc.title	Over-expression of oct4 and sox2 transcription factors enhances differentiation of human umbilical cord blood cells in vivo	ru_RU
dc.type	Articles in international journals and collections	ru_RU