KFU. Card publication. A systems model of phosphorylation for inflammatory signaling events. PLoS One. 2014 Oct 21;9(10):e110913.

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FEDERAL UNIVERSITY

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A SYSTEMS MODEL OF PHOSPHORYLATION FOR INFLAMMATORY SIGNALING EVENTS. PLOS ONE. 2014 OCT 21;9(10):E110913.

Form of presentation

Articles in international journals and collections

Year of publication

2014

Authors, employees of KFU

Kotov Nikolay Viktorovich, author

Bibliographic description in the original language

Sadreev II, Chen MZ, Welsh GI, Umezawa Y, Kotov NV, Valeyev NV. A systems model of phosphorylation for inflammatory signaling events. PLoS One. 2014 Oct 21;9(10):e110913.

Annotation

Phosphorylation is a fundamental biochemical reaction that modulates protein activity in cells. While a single phosphorylation event is relatively easy to understand, multisite phosphorylation requires systems approaches for deeper elucidation of the underlying molecular mechanisms. In this paper we develop a mechanistic model for single- and multi-site phosphorylation. The proposed model is compared with previously reported studies. We compare the predictions of our model with experiments published in the literature in the context of inflammatory signaling events in order to provide a mechanistic description of the multisite phosphorylation-mediated regulation of Signal Transducer and Activator of Transcription 3 (STAT3) and Interferon Regulatory Factor 5 (IRF-5) proteins. The presented model makes crucial predictions for transcription factor phosphorylation events in the immune system. The model proposes potential mechanisms for T cell phenotype switching and production of cytokines.

Keywords

Systems Model, Phosphorylation, Signaling Events.

The name of the journal

PLos ONE

URL

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205014/

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=93373&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kotov Nikolay Viktorovich	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Sadreev II, Chen MZ, Welsh GI, Umezawa Y, Kotov NV, Valeyev NV. A systems model of phosphorylation for inflammatory signaling events. PLoS One. 2014 Oct 21;9(10):e110913.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=93373&p_lang=2	ru_RU
dc.description.abstract	PLos ONE	ru_RU
dc.description.abstract	Phosphorylation is a fundamental biochemical reaction that modulates protein activity in cells. While a single phosphorylation event is relatively easy to understand, multisite phosphorylation requires systems approaches for deeper elucidation of the underlying molecular mechanisms. In this paper we develop a mechanistic model for single- and multi-site phosphorylation. The proposed model is compared with previously reported studies. We compare the predictions of our model with experiments published in the literature in the context of inflammatory signaling events in order to provide a mechanistic description of the multisite phosphorylation-mediated regulation of Signal Transducer and Activator of Transcription 3 (STAT3) and Interferon Regulatory Factor 5 (IRF-5) proteins. The presented model makes crucial predictions for transcription factor phosphorylation events in the immune system. The model proposes potential mechanisms for T cell phenotype switching and production of cytokines.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Systems Model	ru_RU
dc.subject	Phosphorylation	ru_RU
dc.subject	Signaling Events.	ru_RU
dc.title	A systems model of phosphorylation for inflammatory signaling events. PLoS One. 2014 Oct 21;9(10):e110913.	ru_RU
dc.type	Articles in international journals and collections	ru_RU