KFU. Card publication. Effect of NO Synthase Blockade on NO Production in Rat Heart under Conditions of Hypokinesia

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EFFECT OF NO SYNTHASE BLOCKADE ON NO PRODUCTION IN RAT HEART UNDER CONDITIONS OF HYPOKINESIA

Form of presentation

Articles in Russian journals and collections

Year of publication

2014

Authors, employees of KFU

Zaripova Railya Irekovna, author

Zefirov Timur Lvovich, author

Bibliographic description in the original language

Effect of NO Synthase Blockade on NO Production in Rat Heart under Conditions of Hypokinesia

Annotation

Electron paramagnetic (EPR) spectroscopy study showed that 90-day hypokinesia in rats is accompanied by an increase in NO production in the heart. A nonselective NO synthase inhibitor L-NAME decreased the content of NO in the heart atria and ventricles of hypokinetic rats by 67-70%. A selective inhibitor of inducible NO synthase, aminoguanidine, also decreased the level of NO in the heart atria and ventricles of hypokinetic rats by 60-65%. Our results indicate that the increase in NO production during hypokinesia is associated with activation of NO synthases.

Keywords

NO; heart; rat; hypokinesia; electron paramagnetic resonance

The name of the journal

Bulletin of Experimental Biology and Medicine

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=92001&p_lang=2

Resource files

File name	Size (MB)	Format
Statya.2014.3.pdf	0,24	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zaripova Railya Irekovna	ru_RU
dc.contributor.author	Zefirov Timur Lvovich	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Effect of NO Synthase Blockade on NO Production in Rat Heart under Conditions of Hypokinesia	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=92001&p_lang=2	ru_RU
dc.description.abstract	Bulletin of Experimental Biology and Medicine	ru_RU
dc.description.abstract	Electron paramagnetic (EPR) spectroscopy study showed that 90-day hypokinesia in rats is accompanied by an increase in NO production in the heart. A nonselective NO synthase inhibitor L-NAME decreased the content of NO in the heart atria and ventricles of hypokinetic rats by 67-70%. A selective inhibitor of inducible NO synthase, aminoguanidine, also decreased the level of NO in the heart atria and ventricles of hypokinetic rats by 60-65%. Our results indicate that the increase in NO production during hypokinesia is associated with activation of NO synthases.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Effect of NO Synthase Blockade on NO Production in Rat Heart under Conditions of Hypokinesia	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU