KFU. Card publication. Bacterial enzymes effectively digest Alzheimer's β-amyloid peptide

KAZAN
FEDERAL UNIVERSITY

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BACTERIAL ENZYMES EFFECTIVELY DIGEST ALZHEIMER'S β-AMYLOID PEPTIDE

Form of presentation

Articles in international journals and collections

Year of publication

2014

Authors, employees of KFU

Balaban Nelli Pavlovna, author

Danilova Yuliya Vasilevna, author

Margulis Anna Borisovna, author

Rudakova Natalya Leonidovna, author

Toymenceva Anna Aleksandrovna, author

Shagimardanova Elena Ilyasovna, author

Sharipova Margarita Rashidovna, author

Other authors

Palotás A.

Bibliographic description in the original language

Danilova Y.V. Bacterial enzymes effectively digest Alzheimer's β-amyloid peptide / Y.V. Danilova, E.I. Shagimardanova, A.B. Margulis, A.A. Toymentseva, N.P. Balaban, N.L. Rudakova, A.A. Rizvanov, M.R. Sharipova, A. Palotás // Brain Res Bull. - 2014. V.108, No.1. - P.113-117.

Annotation

Aggregated β-amyloid peptides play key roles in the development of Alzheimer's disease, and recent evidence suggests that microbial particles, among others, can facilitate their polymerization. Bacterial enzymes, however, have been proved to be beneficial in degrading pathological fibrillar structures in clinical settings, such as strepto-kinases in resolving blood-clots. The purpose of this study was to investigate the ability of bacterial substances to effectively hydrolyze β-amyloid peptides. Degrading products of several proteinases from Bacillus pumilus were evaluated using MALDI-TOF mass-spectrometry, and their toxicity was assessed in vitro using cell-culture assays and morphological studies. These enzymes have proved to be non-toxic and were demonstrated to cleave through the functional domains of β-amyloid peptide. By yielding inactive fragments, proteinases of Bacillus pumilus may be used as candidate anti-amyloid agents.

Keywords

Bacillus pumilus, extracellular proteinases, Alzheimer's β-amyloid, MALDI-TOF mass-spectrometry

The name of the journal

BRAIN RES BULL

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=90036&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Balaban Nelli Pavlovna	ru_RU
dc.contributor.author	Danilova Yuliya Vasilevna	ru_RU
dc.contributor.author	Margulis Anna Borisovna	ru_RU
dc.contributor.author	Rudakova Natalya Leonidovna	ru_RU
dc.contributor.author	Toymenceva Anna Aleksandrovna	ru_RU
dc.contributor.author	Shagimardanova Elena Ilyasovna	ru_RU
dc.contributor.author	Sharipova Margarita Rashidovna	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Danilova Y.V. Bacterial enzymes effectively digest Alzheimer's β-amyloid peptide / Y.V. Danilova, E.I. Shagimardanova, A.B. Margulis, A.A. Toymentseva, N.P. Balaban, N.L. Rudakova, A.A. Rizvanov, M.R. Sharipova, A. Palotás // Brain Res Bull. - 2014. V.108, No.1. - P.113-117.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=90036&p_lang=2	ru_RU
dc.description.abstract	BRAIN RES BULL	ru_RU
dc.description.abstract	Aggregated β-amyloid peptides play key roles in the development of Alzheimer's disease, and recent evidence suggests that microbial particles, among others, can facilitate their polymerization. Bacterial enzymes, however, have been proved to be beneficial in degrading pathological fibrillar structures in clinical settings, such as strepto-kinases in resolving blood-clots. The purpose of this study was to investigate the ability of bacterial substances to effectively hydrolyze β-amyloid peptides. Degrading products of several proteinases from Bacillus pumilus were evaluated using MALDI-TOF mass-spectrometry, and their toxicity was assessed in vitro using cell-culture assays and morphological studies. These enzymes have proved to be non-toxic and were demonstrated to cleave through the functional domains of β-amyloid peptide. By yielding inactive fragments, proteinases of Bacillus pumilus may be used as candidate anti-amyloid agents.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Bacillus pumilus	ru_RU
dc.subject	extracellular proteinases	ru_RU
dc.subject	Alzheimer's β-amyloid	ru_RU
dc.subject	MALDI-TOF mass-spectrometry	ru_RU
dc.title	Bacterial enzymes effectively digest Alzheimer's β-amyloid peptide	ru_RU
dc.type	Articles in international journals and collections	ru_RU