KFU. Card publication. Characterization of spinal cord glial cells in a model of hindlimb unloading in mice

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CHARACTERIZATION OF SPINAL CORD GLIAL CELLS IN A MODEL OF HINDLIMB UNLOADING IN MICE

Form of presentation

Articles in international journals and collections

Year of publication

2014

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Authors, employees of KFU

Islamov Rustem Robertovich, author

Mukhamedshina Yana Olegovna, author

Nigmetzyanova Mariya Vladimirovna, author

Nikolskiy Evgeniy Evgenevich, author

Rizvanov Albert Anatolevich, author

Chelyshev Yuriy Aleksandrovich, author

Bibliographic description in the original language

Chelyshev Y.A.Characterization of spinal cord glial cells in a model of hindlimb unloading in mice / Y.A. Chelyshev, Y.O. Muhamedshina, T.V. Povysheva, G.F. Shaymardanova, A.A. Rizvanov, M.V. Nigmetzyanova, O.V. Tiapkina, N.I. Bondarenko, E.E. Nikolskiy, R.R. Islamov // Neuroscience. - 2014. - V.280. - P.328-339.

Annotation

Neuroscience

Keywords

hindlimb unloading model, spinal cord, glia, myelin

The name of the journal

NEUROSCIENCE

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=89578&p_lang=2

Resource files

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2014_CHARACTERIZATION_OF_SPINAL_CORD_GLIAL_CELLS_IN_A_MODEL.pdf	3,17	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Islamov Rustem Robertovich	ru_RU
dc.contributor.author	Mukhamedshina Yana Olegovna	ru_RU
dc.contributor.author	Nigmetzyanova Mariya Vladimirovna	ru_RU
dc.contributor.author	Nikolskiy Evgeniy Evgenevich	ru_RU
dc.contributor.author	Rizvanov Albert Anatolevich	ru_RU
dc.contributor.author	Chelyshev Yuriy Aleksandrovich	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Chelyshev Y.A.Characterization of spinal cord glial cells in a model of hindlimb unloading in mice / Y.A. Chelyshev, Y.O. Muhamedshina, T.V. Povysheva, G.F. Shaymardanova, A.A. Rizvanov, M.V. Nigmetzyanova, O.V. Tiapkina, N.I. Bondarenko, E.E. Nikolskiy, R.R. Islamov // Neuroscience. - 2014. - V.280. - P.328-339.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=89578&p_lang=2	ru_RU
dc.description.abstract	NEUROSCIENCE	ru_RU
dc.description.abstract	Neuroscience	ru_RU
dc.description.abstract	We investigated the effects of microgravity by using a hindlimb unloading model (HUM) in mice. The characteristics of the lumbar spinal cords of HUM mice 30 days after hindlimb unloading were examined. Morphometric analysis showed reductions of the total area, gray and white matter by 17%, 20%, and 12%, respectively. Myelinated fibers in the white matter showed prominent myelin destruction. Analysis of the number of (GFAP+)/S100B+, GFAP+/S100B+, and GFAP?/S100B+ astrocytes in the ventral horn (VH), central channel area (CC), dorsal root entry zone (DREZ), main corticospinal tract (CST), and ventral funiculi (VF) showed that the number of GFAP+/S100B? astrocytes was increased in the DREZ and CST of HUM mice. Additionally, GFAP+/S100B+ cell numbers were significantly decreased in the VH and CST but did not differ in the CC or DREZ of HUM mice, as compared with the control. The numbers of GFAP?/S100B+ cells were significantly reduced only in the VH of HUM mice.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	hindlimb unloading model	ru_RU
dc.subject	spinal cord	ru_RU
dc.subject	glia	ru_RU
dc.subject	myelin	ru_RU
dc.title	Characterization of spinal cord glial cells in a model of hindlimb unloading in mice	ru_RU
dc.type	Articles in international journals and collections	ru_RU