KFU. Card publication. Inhibition of biofilm formation in Bacillus subtilis by new halogenated furanones.

KAZAN
FEDERAL UNIVERSITY

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INHIBITION OF BIOFILM FORMATION IN BACILLUS SUBTILIS BY NEW HALOGENATED FURANONES.

Form of presentation

Articles in international journals and collections

Year of publication

2014

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Authors, employees of KFU

Kurbangalieva Almira Rafaelovna, author

Margulis Anna Borisovna, author

Trizna Elena Yurevna, author

Authors, postgraduates KFU

Khoang Tkhi Lien, postgraduate kfu

Bibliographic description in the original language

A. R. Kayumov, E. N. Khakimullina, I. S. Sharafutdinov, E. Y. Trizna, L. Z. Latypova, L. Hoang, A. B. Margulis, M. I. Bogachev, A. R. Kurbangalieva. Inhibition of biofilm formation in Bacillus subtilis by new halogenated furanones // J. Antibiot. - 2014. doi: 10.1038/ja.2014.143 (prinyata v pechat)

Annotation

Gram-positive bacteria can cause various infections including hospital-acquired infections. While in the biofilm, the resistance of bacteria to both antibiotics and the human immune system is increased causing difficulties in the treatment. Bacillus subtilis, a non-pathogenic Gram-positive bacterium, is widely used as a model organism for studying biofilm formation. Here we investigated the effect of novel synthesized chloro- and bromo-containing 2(5H)-furanones on biofilm formation by B. subtilis. Mucobromic acid (3,4-dibromo-5-hydroxy-2(5H)-furanone) and the two derivatives of mucochloric acid (3,4-dichloro-5-hydroxy-2(5H)-furanone)?F8 and F12?were found to inhibit the growth and to efficiently prevent biofilm formation by B. subtilis. Along with the low production of polysaccharide matrix and repression of the eps operon, strong repression of biofilm-related yqxM also occurred in the presence of furanones.

Keywords

Gram-positive bacteria, 2(5H)-furanones, biofilm formation

The name of the journal

The Journal of Antibiotics

URL

http://www.nature.com/ja/journal/vaop/ncurrent/full/ja2014143a.html

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=88600&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kurbangalieva Almira Rafaelovna	ru_RU
dc.contributor.author	Margulis Anna Borisovna	ru_RU
dc.contributor.author	Trizna Elena Yurevna	ru_RU
dc.contributor.author	Khoang Tkhi Lien	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	A. R. Kayumov, E. N. Khakimullina, I. S. Sharafutdinov, E. Y. Trizna, L. Z. Latypova, L. Hoang, A. B. Margulis, M. I. Bogachev, A. R. Kurbangalieva. Inhibition of biofilm formation in Bacillus subtilis by new halogenated furanones // J. Antibiot. - 2014. doi: 10.1038/ja.2014.143 (�� )	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=88600&p_lang=2	ru_RU
dc.description.abstract	The Journal of Antibiotics	ru_RU
dc.description.abstract	Gram-positive bacteria can cause various infections including hospital-acquired infections. While in the biofilm, the resistance of bacteria to both antibiotics and the human immune system is increased causing difficulties in the treatment. Bacillus subtilis, a non-pathogenic Gram-positive bacterium, is widely used as a model organism for studying biofilm formation. Here we investigated the effect of novel synthesized chloro- and bromo-containing 2(5H)-furanones on biofilm formation by B. subtilis. Mucobromic acid (3,4-dibromo-5-hydroxy-2(5H)-furanone) and the two derivatives of mucochloric acid (3,4-dichloro-5-hydroxy-2(5H)-furanone)?F8 and F12?were found to inhibit the growth and to efficiently prevent biofilm formation by B. subtilis. Along with the low production of polysaccharide matrix and repression of the eps operon, strong repression of biofilm-related yqxM also occurred in the presence of furanones.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Gram-positive bacteria	ru_RU
dc.subject	2(5H)-furanones	ru_RU
dc.subject	biofilm formation	ru_RU
dc.title	Inhibition of biofilm formation in Bacillus subtilis by new halogenated furanones.	ru_RU
dc.type	Articles in international journals and collections	ru_RU