KFU. Card publication. Universal internucleotide statistics in full genomes: A footprint of the DNA structure and packaging.

KAZAN
FEDERAL UNIVERSITY

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UNIVERSAL INTERNUCLEOTIDE STATISTICS IN FULL GENOMES: A FOOTPRINT OF THE DNA STRUCTURE AND PACKAGING.

Form of presentation

Articles in international journals and collections

Year of publication

2014

Authors, employees of KFU

Kayumov Ayrat Rashitovich, author

Other authors

Bogachev M. I.; Bunde A.

Bibliographic description in the original language

Bogachev M. I., Kayumov A. R., Bunde A. Universal internucleotide statistics in full genomes: A footprint of the DNA structure and packaging? // Plos One. - December 1, 2014. Doi: 10.1371/journal.pone.0112534.

Annotation

Uncovering the fundamental laws that govern the complex DNA structural organization remains challenging and is largely based upon reconstructions from the primary nucleotide sequences. Here we investigate the distributions of the internucleotide intervals and their persistence properties in complete genomes of various organisms from Archaea and Bacteria to H. Sapiens aiming to reveal the manifestation of the universal DNA architecture. We find that in all considered organisms the internucleotide interval distributions exhibit the same q -exponential form. While in prokaryotes a single q-exponential function makes the best fit, in eukaryotes the PDF contains additionally a second q -exponential, which in the human genome makes a perfect approximation over nearly 10 decades. We suggest that this functional form is a footprint of the heterogeneous DNA structure, where the first q-exponential reflects the universal helical pitch that appears both in pro- and eukaryotic DNA, while the second q -exponential is a specific marker of the large-scale eukaryotic DNA organization.

Keywords

The name of the journal

PLos ONE

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=88595&p_lang=2

Resource files

File name	Size (MB)	Format
journal.pone.0112534.pdf	1,33	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kayumov Ayrat Rashitovich	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Bogachev M. I., Kayumov A. R., Bunde A. Universal internucleotide statistics in full genomes: A footprint of the DNA structure and packaging? // Plos One. - December 1, 2014. Doi: 10.1371/journal.pone.0112534.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=88595&p_lang=2	ru_RU
dc.description.abstract	PLos ONE	ru_RU
dc.description.abstract	Uncovering the fundamental laws that govern the complex DNA structural organization remains challenging and is largely based upon reconstructions from the primary nucleotide sequences. Here we investigate the distributions of the internucleotide intervals and their persistence properties in complete genomes of various organisms from Archaea and Bacteria to H. Sapiens aiming to reveal the manifestation of the universal DNA architecture. We find that in all considered organisms the internucleotide interval distributions exhibit the same q -exponential form. While in prokaryotes a single q-exponential function makes the best fit, in eukaryotes the PDF contains additionally a second q -exponential, which in the human genome makes a perfect approximation over nearly 10 decades. We suggest that this functional form is a footprint of the heterogeneous DNA structure, where the first q-exponential reflects the universal helical pitch that appears both in pro- and eukaryotic DNA, while the second q -exponential is a specific marker of the large-scale eukaryotic DNA organization.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Universal internucleotide statistics in full genomes: A footprint of the DNA structure and packaging.	ru_RU
dc.type	Articles in international journals and collections	ru_RU