KFU. Card publication. Microfluidic Mixing of Polyamine with Acrolein Enables the Detection of the [4+4] Polymerization of Intermediary Unsaturated Imines: The Properties of a Cytotoxic 1,5-Diazacyclooctane Hydrogel

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MICROFLUIDIC MIXING OF POLYAMINE WITH ACROLEIN ENABLES THE DETECTION OF THE [4+4] POLYMERIZATION OF INTERMEDIARY UNSATURATED IMINES: THE PROPERTIES OF A CYTOTOXIC 1,5-DIAZACYCLOOCTANE HYDROGEL

Form of presentation

Articles in international journals and collections

Year of publication

2014

Authors, employees of KFU

Kurbangalieva Almira Rafaelovna, author

Other authors

A. Pradipta; A. Tsutsui; A. Ogura; S. Hanashima; Y. Yamaguchi

Bibliographic description in the original language

A. Pradipta, A. Tsutsui, A. Ogura, S. Hanashima, Y. Yamaguchi, A. Kurbangalieva, K. Tanaka. Microfluidic Mixing of Polyamine with Acrolein Enables the Detection of the [4+4] Polymerization of Intermediary Unsaturated Imines: The Properties of a Cytotoxic 1,5-Diazacyclooctane Hydrogel // Synlett. 2014. V. 25. � 17. P. 2442-2446.

Annotation

The [4+4] polymerization of an unsaturated imine, generated from the condensation of a polyamine and excess acrolein, was investigated. The polyamine was added by micropipet to acrolein, immediately yielding a mixture of the immiscible polymeric material. Microfluidic mixing was used to gradually form the soluble diazacyclooctane polymers. The polymerization reaction ultimately gave an insoluble cationic hydrogel that adhered strongly to anionic compounds on cell surfaces, including sialoglycan, and displayed a high cytotoxicity.

Keywords

acrolein, N-alkyl unsaturated imine, cytotoxicity, 1,5-diazacyclooctane, hydrogel, microreactor, polyamine,[4+4] polymerization, sialoglycan

The name of the journal

Synlett

URL

https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0034-1378634

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=87124&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kurbangalieva Almira Rafaelovna	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	A. Pradipta, A. Tsutsui, A. Ogura, S. Hanashima, Y. Yamaguchi, A. Kurbangalieva, K. Tanaka. Microfluidic Mixing of Polyamine with Acrolein Enables the Detection of the [4+4] Polymerization of Intermediary Unsaturated Imines: The Properties of a Cytotoxic 1,5-Diazacyclooctane Hydrogel // Synlett. 2014. V. 25. � 17. P. 2442-2446.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=87124&p_lang=2	ru_RU
dc.description.abstract	Synlett	ru_RU
dc.description.abstract	The [4+4] polymerization of an unsaturated imine, generated from the condensation of a polyamine and excess acrolein, was investigated. The polyamine was added by micropipet to acrolein, immediately yielding a mixture of the immiscible polymeric material. Microfluidic mixing was used to gradually form the soluble diazacyclooctane polymers. The polymerization reaction ultimately gave an insoluble cationic hydrogel that adhered strongly to anionic compounds on cell surfaces, including sialoglycan, and displayed a high cytotoxicity.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	acrolein	ru_RU
dc.subject	N-alkyl unsaturated imine	ru_RU
dc.subject	cytotoxicity	ru_RU
dc.subject	1	ru_RU
dc.subject	5-diazacyclooctane	ru_RU
dc.subject	hydrogel	ru_RU
dc.subject	microreactor	ru_RU
dc.subject	polyamine	ru_RU
dc.subject	[4+4] polymerization	ru_RU
dc.subject	sialoglycan	ru_RU
dc.title	Microfluidic Mixing of Polyamine with Acrolein Enables the Detection of the [4+4] Polymerization of Intermediary Unsaturated Imines: The Properties of a Cytotoxic 1,5-Diazacyclooctane Hydrogel	ru_RU
dc.type	Articles in international journals and collections	ru_RU