KFU. Card publication. Polyamine modification by acrolein exclusively produces 1,5-diazacyclooctanes: A previously unrecognized mechanism for acrolein-mediated oxidative stress

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POLYAMINE MODIFICATION BY ACROLEIN EXCLUSIVELY PRODUCES 1,5-DIAZACYCLOOCTANES: A PREVIOUSLY UNRECOGNIZED MECHANISM FOR ACROLEIN-MEDIATED OXIDATIVE STRESS

Form of presentation

Articles in international journals and collections

Year of publication

2014

Authors, employees of KFU

Kurbangalieva Almira Rafaelovna, author

Other authors

A. Tsutsui; R. Imamak; S. Kitazume; S. Hanashima; Y. Yamaguchi; M. Kaneda; S. Oishi; N. Fujii; N. Taniguchi

Bibliographic description in the original language

A. Tsutsui, R. Imamaki, S. Kitazume, S. Hanashima, Y. Yamaguchi, M. Kaneda, S. Oishi, N. Fujii, A. Kurbangalieva, N. Taniguchi, K. Tanaka. Polyamine modification by acrolein exclusively produces 1,5-diazacyclooctanes: A previously unrecognized mechanism for acrolein-mediated oxidative stress // Org. Biomol. Chem. 2014. V. 12. � 28. P. 5151-5157.

Annotation

Acrolein, a toxic unsaturated aldehyde generated as a result of oxidative stress, readily reacts with a variety of nucleophilic biomolecules. Polyamines, which produced acrolein in the presence of amine oxidase, were then found to react with acrolein to produce 1,5-diazacyclooctane, a previously unrecognized but significant downstream product of oxidative stress. Although diazacyclooctane formation effectively neutralized acrolein toxicity, the diazacyclooctane hydrogel produced through a sequential diazacyclooctane polymerization reaction was highly cytotoxic. This study suggests that diazacyclooctane formation is involved in the mechanism underlying acrolein-mediated oxidative stress.

Keywords

acrolein, oxidative stress, polyamine, 1,5-diazacyclooctanes

The name of the journal

Org. Biomol. Chem.

URL

http://pubs.rsc.org/en/content/articlelanding/2014/ob/c4ob00761a#divAbstract

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=87123&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kurbangalieva Almira Rafaelovna	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	A. Tsutsui, R. Imamaki, S. Kitazume, S. Hanashima, Y. Yamaguchi, M. Kaneda, S. Oishi, N. Fujii, A. Kurbangalieva, N. Taniguchi, K. Tanaka. Polyamine modification by acrolein exclusively produces 1,5-diazacyclooctanes: A previously unrecognized mechanism for acrolein-mediated oxidative stress // Org. Biomol. Chem. 2014. V. 12. � 28. P. 5151-5157.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=87123&p_lang=2	ru_RU
dc.description.abstract	Org. Biomol. Chem.	ru_RU
dc.description.abstract	Acrolein, a toxic unsaturated aldehyde generated as a result of oxidative stress, readily reacts with a variety of nucleophilic biomolecules. Polyamines, which produced acrolein in the presence of amine oxidase, were then found to react with acrolein to produce 1,5-diazacyclooctane, a previously unrecognized but significant downstream product of oxidative stress. Although diazacyclooctane formation effectively neutralized acrolein toxicity, the diazacyclooctane hydrogel produced through a sequential diazacyclooctane polymerization reaction was highly cytotoxic. This study suggests that diazacyclooctane formation is involved in the mechanism underlying acrolein-mediated oxidative stress.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	acrolein	ru_RU
dc.subject	oxidative stress	ru_RU
dc.subject	polyamine	ru_RU
dc.subject	1	ru_RU
dc.subject	5-diazacyclooctanes	ru_RU
dc.title	Polyamine modification by acrolein exclusively produces 1,5-diazacyclooctanes: A previously unrecognized mechanism for acrolein-mediated oxidative stress	ru_RU
dc.type	Articles in international journals and collections	ru_RU