KFU. Card publication. Modification of the Anticestodal Drug 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide with a View to Improve Its Biological Effect.

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MODIFICATION OF THE ANTICESTODAL DRUG 5-CHLORO-N-(2-CHLORO-4-NITROPHENYL)-2-HYDROXYBENZAMIDE WITH A VIEW TO IMPROVE ITS BIOLOGICAL EFFECT.

Form of presentation

Articles in Russian journals and collections

Year of publication

2014

Authors, employees of KFU

Bakhtiyarova Yuliya Valerevna, author

Galkin Vladimir Ivanovich, author

Galkina Irina Vasilevna, author

Islamov Daut Rinatovich, author

Kataeva Olga Nikolaevna, author

Cherkasov Rafael Askhatovich, author

Chubukaeva Dinara Rashitovna, author

Bibliographic description in the original language

I.V. Galkinaa, D. R. Chubukaevaa, Yu.V.Bakhtiyarovaa, V.I. Galkina, R.A. Cherkasova, D. R. Islamova, and O.N. Kataeva, Modification of the Anticestodal Drug 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide with a View to Improve Its Biological Effect,Russian Journal of Organic Chemistry, 2014, Vol.50, No 6, pp.812-822.DOI: 10.1134/S1070428014060074

Annotation

?Reactions of 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide, the active substance of the drug Niclosamide (Phenasal), with higher amines (dodecan-1-amine, hexadecan-1-amine) and 1-(2-aminoethyl)-piperazine lead to the formation of the corresponding water-soluble ammonium salts with retention of pharmacophoric groups responsible for the antihelminthic effect, whereas no nucleophilic aromatic substitution of chlorine is observed. The product structure was determined by X-ray analysis.

Keywords

anticestodal drug, modification, biological effect, 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide

The name of the journal

J ORG CHEM

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=83922&p_lang=2

Resource files

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Rjoc0800.pdf	0,31	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Bakhtiyarova Yuliya Valerevna	ru_RU
dc.contributor.author	Galkin Vladimir Ivanovich	ru_RU
dc.contributor.author	Galkina Irina Vasilevna	ru_RU
dc.contributor.author	Islamov Daut Rinatovich	ru_RU
dc.contributor.author	Kataeva Olga Nikolaevna	ru_RU
dc.contributor.author	Cherkasov Rafael Askhatovich	ru_RU
dc.contributor.author	Chubukaeva Dinara Rashitovna	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	I.V. Galkinaa, D. R. Chubukaevaa, Yu.V.Bakhtiyarovaa, V.I. Galkina, R.A. Cherkasova, D. R. Islamova, and O.N. Kataeva, Modification of the Anticestodal Drug 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide with a View to Improve Its Biological Effect,Russian Journal of Organic Chemistry, 2014, Vol.50, No 6, pp.812-822.DOI: 10.1134/S1070428014060074	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=83922&p_lang=2	ru_RU
dc.description.abstract	J ORG CHEM	ru_RU
dc.description.abstract	?Reactions of 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide, the active substance of the drug Niclosamide (Phenasal), with higher amines (dodecan-1-amine, hexadecan-1-amine) and 1-(2-aminoethyl)-piperazine lead to the formation of the corresponding water-soluble ammonium salts with retention of pharmacophoric groups responsible for the antihelminthic effect, whereas no nucleophilic aromatic substitution of chlorine is observed. The product structure was determined by X-ray analysis.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	anticestodal drug	ru_RU
dc.subject	modification	ru_RU
dc.subject	biological effect	ru_RU
dc.subject	5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide	ru_RU
dc.title	Modification of the Anticestodal Drug 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide with a View to Improve Its Biological Effect.	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU