KFU. Card publication. Adaptation of mycoplasmas to antimicrobial agents: Acholeplasma laidlawii extracellular vesicles mediate the export of ciprofloxacin and a mutant gene related to the antibiotic target

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ADAPTATION OF MYCOPLASMAS TO ANTIMICROBIAL AGENTS: ACHOLEPLASMA LAIDLAWII EXTRACELLULAR VESICLES MEDIATE THE EXPORT OF CIPROFLOXACIN AND A MUTANT GENE RELATED TO THE ANTIBIOTIC TARGET

Form of presentation

Articles in international journals and collections

Year of publication

2014

Authors, employees of KFU

Trushin Maksim Viktorovich, author

Bibliographic description in the original language

Medvedeva, E.S.a , Baranova, N.B.a , Mouzykantov, A.A.a , Grigorieva, T.Y.a , Davydova, M.N.a , Trushin, M.V.ab , Chernova, O.A.ab , Chernov, V.M. Adaptation of mycoplasmas to antimicrobial agents: Acholeplasma laidlawii extracellular vesicles mediate the export of ciprofloxacin and a mutant gene related to the antibiotic target // The Scientific World Journal Volume 2014, 2014, Article number 150615

Annotation

This study demonstrated that extracellular membrane vesicles are involved with the development of resistance to fluoroquinolones by mycoplasmas (class Mollicutes). This study assessed the differences in susceptibility to ciprofloxacin among strains of Acholeplasma laidlawii PG8. The mechanisms of mycoplasma resistance to antibiotics may be associated with a mutation in a gene related to the target of quinolones, which could modulate the vesiculation level. A. laidlawii extracellular vesicles mediated the export of the nucleotide sequences of the antibiotic target gene as well as the traffic of ciprofloxacin. These results may facilitate the development of effective approaches to control mycoplasma infections, as well as the contamination of cell cultures and vaccine preparations.

Keywords

Acholeplasma laidlawii; antibiotic resistance; article; cell culture; cell vacuole; drug targeting; drug transport; gene mutation; Mycoplasma; mycoplasmosis; nonhuman; nucleotide sequence

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=83848&p_lang=2

Resource files

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tswj_chernov_2014_150615.pdf	2,52	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Trushin Maksim Viktorovich	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Medvedeva, E.S.a , Baranova, N.B.a , Mouzykantov, A.A.a , Grigorieva, T.Y.a , Davydova, M.N.a , Trushin, M.V.ab , Chernova, O.A.ab , Chernov, V.M. Adaptation of mycoplasmas to antimicrobial agents: Acholeplasma laidlawii extracellular vesicles mediate the export of ciprofloxacin and a mutant gene related to the antibiotic target // The Scientific World Journal Volume 2014, 2014, Article number 150615	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=83848&p_lang=2	ru_RU
dc.description.abstract	This study demonstrated that extracellular membrane vesicles are involved with the development of resistance to fluoroquinolones by mycoplasmas (class Mollicutes). This study assessed the differences in susceptibility to ciprofloxacin among strains of Acholeplasma laidlawii PG8. The mechanisms of mycoplasma resistance to antibiotics may be associated with a mutation in a gene related to the target of quinolones, which could modulate the vesiculation level. A. laidlawii extracellular vesicles mediated the export of the nucleotide sequences of the antibiotic target gene as well as the traffic of ciprofloxacin. These results may facilitate the development of effective approaches to control mycoplasma infections, as well as the contamination of cell cultures and vaccine preparations.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Adaptation of mycoplasmas to antimicrobial agents: Acholeplasma laidlawii extracellular vesicles mediate the export of ciprofloxacin and a mutant gene related to the antibiotic target	ru_RU
dc.type	Articles in international journals and collections	ru_RU