Kazan (Volga region) Federal University, KFU
KAZAN
FEDERAL UNIVERSITY
 
EXCLUSIVE FORMATION OF IMINO[4+4]CYCLOADDITION PRODUCTS WITH BIOLOGICALLY RELEVANT AMINES: PLAUSIBLE CANDIDATES FOR ACROLEIN BIOMARKERS AND BIOFUNCTIONAL MODULATORS
Form of presentationArticles in international journals and collections
Year of publication2015
Языканглийский
  • Saygitbatalova Elena Shiripovna, author
  • Saygitbatalova Elena Shiripovna, postgraduate kfu
  • Bibliographic description in the original language Tsutsui A. Exclusive formation of imino[4+4]cycloaddition products with biologically relevant amines: plausible candidates for acrolein biomarkers and biofunctional modulators / A. Tsutsui, A. R. Pradipta, E. Saigitbatalova, A. Kurbangalieva, K. Tanaka // Med. Chem. Commun. - 2015. - V. 6. - N. 3. - P. 431-436.
    Annotation We synthetically demonstrate that eight-membered heterocycles, namely, 2,6,9-triazabicyclo[3.3.1]-nonanes and 1,5-diazacyclooctanes, are the exclusive products of the reaction of acrolein with biologically relevant amines via an imino[4 + 4]cycloaddition. These compounds are produced in much higher amounts and efficiencies than the acrolein biomarker in current use, 3-formyl-3,4-dehydropiperidine (FDP). Our results not only indicate that eight-membered heterocycles may potentially be used as new biomarkers, but also strongly suggest the involvement of these heterocycles in various important biological phenomena, e.g., an acrolein-mediated mechanism underlying oxidative stress.
    Keywords acrolein, 2,6,9-triazabicyclo[3.3.1]nonanes, 1,5-diazacyclooctanes, oxidative stress
    The name of the journal Medicinal Chemical Communications
    URL http://pubs.rsc.org/en/content/articlelanding/2015/md/c4md00383g#!divAbstract
    Please use this ID to quote from or refer to the card https://repository.kpfu.ru/eng/?p_id=83350&p_lang=2

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