KFU. Card publication. Internalization of Bacillus intermedius ribonuclease (BINASE) induces human alveolar adenocarcinoma cell death.

KAZAN
FEDERAL UNIVERSITY

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INTERNALIZATION OF BACILLUS INTERMEDIUS RIBONUCLEASE (BINASE) INDUCES HUMAN ALVEOLAR ADENOCARCINOMA CELL DEATH.

Form of presentation

Articles in international journals and collections

Year of publication

2013

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Authors, employees of KFU

Zelenikhin Pavel Valerevich, author

Ilinskaya Olga Nikolaevna, author

Kolpakov Aleksey Ivanovich, author

Bibliographic description in the original language

Cabrera-Fuentes, H.A. Internalization of Bacillus intermedius ribonuclease (BINASE) induces human alveolar adenocarcinoma cell death [Text] / H.A. Cabrera-Fuentes, M. Aslam, M. Saffarzadeh, A. Kolpakov, P. Zelenikhin, K.T. Preissner, O.N. Ilinskaya // Toxicon.- 2013.- V.69.- P.219-226

Annotation

Toxicon

Keywords

Cytotoxic RNase, Binase, Human alveolar adenocarcinoma cells, Permeability, Internalization, DSB, Apoptosis

The name of the journal

Toxicon

URL

http://www.sciencedirect.com/science/article/pii/S0041010113001104

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=79004&p_lang=2

Resource files

File name	Size (MB)	Format
1_s2.0_S0041010113001104_main.pdf	3,08	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zelenikhin Pavel Valerevich	ru_RU
dc.contributor.author	Ilinskaya Olga Nikolaevna	ru_RU
dc.contributor.author	Kolpakov Aleksey Ivanovich	ru_RU
dc.date.accessioned	2013-01-01T00:00:00Z	ru_RU
dc.date.available	2013-01-01T00:00:00Z	ru_RU
dc.date.issued	2013	ru_RU
dc.identifier.citation	Cabrera-Fuentes, H.A. Internalization of Bacillus intermedius ribonuclease (BINASE) induces human alveolar adenocarcinoma cell death [Text] / H.A. Cabrera-Fuentes, M. Aslam, M. Saffarzadeh, A. Kolpakov, P. Zelenikhin, K.T. Preissner, O.N. Ilinskaya // Toxicon.- 2013.- V.69.- P.219-226	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=79004&p_lang=2	ru_RU
dc.description.abstract	Toxicon	ru_RU
dc.description.abstract	Toxicon	ru_RU
dc.description.abstract	Ribonuclease (RNase) treatment represents a novel mechanism based approach to anticancer therapy as an alternative to the DNA damaging drugs commonly used in clinical practice. Apart from their ribonucleolytic activity, cytotoxic effects have attracted a considerable attention to RNases because of their potential as selective agents for treatment of certain malignancies. Among these enzymes, Binase, an RNase from Bacillus intermedius, has shown promising results. Here, we have found that binase selectively attacked human A549 alveolar adenocarcinoma cells to trigger an apoptotic response, whereas normal lung epithelial cells LEK were not affected by the ribonuclease.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Cytotoxic RNase	ru_RU
dc.subject	Binase	ru_RU
dc.subject	Human alveolar adenocarcinoma cells	ru_RU
dc.subject	Permeability	ru_RU
dc.subject	Internalization	ru_RU
dc.subject	DSB	ru_RU
dc.subject	Apoptosis	ru_RU
dc.title	Internalization of Bacillus intermedius ribonuclease (BINASE) induces human alveolar adenocarcinoma cell death.	ru_RU
dc.type	Articles in international journals and collections	ru_RU