KFU. Card publication. Inversion of Population Distribution of Felodipine Conformations at Increased Concentration in Dimethyl Sulfoxide Is a Prerequisite to Crystal Nucleation

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INVERSION OF POPULATION DISTRIBUTION OF FELODIPINE CONFORMATIONS AT INCREASED CONCENTRATION IN DIMETHYL SULFOXIDE IS A PREREQUISITE TO CRYSTAL NUCLEATION

Form of presentation

Articles in international journals and collections

Year of publication

2014

Authors, employees of KFU

Efimov Sergey Vladimirovich, author

Other authors

M.Yu. Nikiforov; N. Georgi

Bibliographic description in the original language

Khodov, I.A. Inversion of Population Distribution of Felodipine Conformations at Increased Concentration in Dimethyl Sulfoxide Is a Prerequisite to Crystal Nucleation / I.A. Khodov, S.V. Efimov, M.Yu. Nikiforov, V.V. Klochkov, N. Georgi // J. Pharm. Sci. – 2014. – Vol. 103, No. 2. – P. 392-394. – DOI 10.1002/jps.23833

Annotation

Journal of Pharmaceutical Sciences

Keywords

NMR spectroscopy, nucleation, structure, polymorphism, crystallization

The name of the journal

Journal of Pharmaceutical Sciences

URL

http://onlinelibrary.wiley.com/doi/10.1002/jps.23833/abstract

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=77790&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Efimov Sergey Vladimirovich	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Khodov, I.A. Inversion of Population Distribution of Felodipine Conformations at Increased Concentration in Dimethyl Sulfoxide Is a Prerequisite to Crystal Nucleation / I.A. Khodov, S.V. Efimov, M.Yu. Nikiforov, V.V. Klochkov, N. Georgi // J. Pharm. Sci. – 2014. – Vol. 103, No. 2. – P. 392-394. – DOI 10.1002/jps.23833	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=77790&p_lang=2	ru_RU
dc.description.abstract	Journal of Pharmaceutical Sciences	ru_RU
dc.description.abstract	Journal of Pharmaceutical Sciences	ru_RU
dc.description.abstract	Knowledge of the preferred conformations of biologically active compounds is of the utmost importance for a better understanding of the structure?activity relationships underlying their biological activity, as well as their mechanism of action. Moreover, investigating the mechanism of nucleation from a saturated solution can facilitate the discovery and preparation of new polymorphic forms. To search regularities in the crystal nucleation of biologically active compounds (drugs) from a saturated solution, we studied the conformational preference of felodipine in dilute and saturated solution in dimethyl sulfoxide. Inversion of conformation distribution at increased concentration occurs: conformers which dominate in a dilute solution become the least abundant in the saturated one. Conformers which dominate in the saturated solution are of the same type as revealed in crystalline state by X-ray.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	NMR spectroscopy	ru_RU
dc.subject	nucleation	ru_RU
dc.subject	structure	ru_RU
dc.subject	polymorphism	ru_RU
dc.subject	crystallization	ru_RU
dc.title	Inversion of Population Distribution of Felodipine Conformations at Increased Concentration in Dimethyl Sulfoxide Is a Prerequisite to Crystal Nucleation	ru_RU
dc.type	Articles in international journals and collections	ru_RU