KFU. Card publication. Formation of solid dispersion of PEG-1000 with phenacetin according to differential scanning calorimetry

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FEDERAL UNIVERSITY

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FORMATION OF SOLID DISPERSION OF PEG-1000 WITH PHENACETIN ACCORDING TO DIFFERENTIAL SCANNING CALORIMETRY

Form of presentation

Articles in international journals and collections

Year of publication

2013

Authors, employees of KFU

Gerasimov Aleksandr Vladimirovich, author

Gorbachuk Valeriy Vilenovich, author

Ziganshin Marat Akhmedovich, author

Authors, students KFU

Usmanova Liana Stanislavovna, author

Bibliographic description in the original language

Gerasimov, A.V. Formation of solid dispersion of PEG-1000 with phenacetin according to differential scanning calorimetry / A.V. Gerasimov, M.A. Ziganshin, V.V. Gorbatchuk, L.S. Usmanova // Der Pharma Chemica. – 2013. – V.5, N.6. – P.149-155.

Annotation

Der Pharma Chemica

Keywords

phenacetin, polyethylene glycol, solid dispersion, differential scanning calorimetry

The name of the journal

Der Pharma Chemica

URL

http://derpharmachemica.com/vol5-iss6/DPC-2013-5-6-149-155.pdf

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=75998&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Gerasimov Aleksandr Vladimirovich	ru_RU
dc.contributor.author	Gorbachuk Valeriy Vilenovich	ru_RU
dc.contributor.author	Ziganshin Marat Akhmedovich	ru_RU
dc.contributor.author	Usmanova Liana Stanislavovna	ru_RU
dc.date.accessioned	2013-01-01T00:00:00Z	ru_RU
dc.date.available	2013-01-01T00:00:00Z	ru_RU
dc.date.issued	2013	ru_RU
dc.identifier.citation	Gerasimov, A.V. Formation of solid dispersion of PEG-1000 with phenacetin according to differential scanning calorimetry / A.V. Gerasimov, M.A. Ziganshin, V.V. Gorbatchuk, L.S. Usmanova // Der Pharma Chemica. – 2013. – V.5, N.6. – P.149-155.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=75998&p_lang=2	ru_RU
dc.description.abstract	Der Pharma Chemica	ru_RU
dc.description.abstract	Der Pharma Chemica	ru_RU
dc.description.abstract	The formation of solid dispersions is one of the methods for drug hydrophilization. The data obtained by low temperature differential scanning calorimetry (DSC) has shown an opportunity to formation of solid dispersions of a hydrophobic drug ? phenacetin with a biocompatible polymer ? polyethylene glycol. It was established that in case of polymer:phenacetin 5-10:1 ratios the crystalline phase of the drug is not formed, while in case of 1-4:1 ratios the pharmacological component shows features of a separate phase and does not form a solid dispersion. The observed exo-effects on DSC curves of the mixtures of polymer:phenacetin with ratios of 1-2:1 and 7-10:1 are related to low-temperature crystallization of polymer. Optimal polymer:drug ratio is 5-6:1. At these ratios phenacetin completely dissolved in the polyethylene glycol phase and the quasi-stationary state caused amorphous part in solid dispersion is not observed. This together with absence of polymer plasticization by phenacetin may facilitate the release of the drug from the composite in hydrophilic media. The melting temperature of solid dispersions does not exceed 35.2 ?� allowing their use as capsular drugs, ointments and suppositories.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	phenacetin	ru_RU
dc.subject	polyethylene glycol	ru_RU
dc.subject	solid dispersion	ru_RU
dc.subject	differential scanning calorimetry	ru_RU
dc.title	Formation of solid dispersion of PEG-1000 with phenacetin according to differential scanning calorimetry	ru_RU
dc.type	Articles in international journals and collections	ru_RU