KFU. Card publication. Performance of the Enferplex TB assay with cattle in Great Britain and assessment of its suitability as a test to distinguish infected and vaccinated animals

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PERFORMANCE OF THE ENFERPLEX TB ASSAY WITH CATTLE IN GREAT BRITAIN AND ASSESSMENT OF ITS SUITABILITY AS A TEST TO DISTINGUISH INFECTED AND VACCINATED ANIMALS

Form of presentation

Articles in international journals and collections

Year of publication

2010

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Authors, employees of KFU

Shuralev Eduard Arkadevich, author

Other authors

Clarke John , author

Hewinson Glyn , author

Kwok Hang Fai , author

Vordermeier H. Martin , author

Whelan Adam O. , author

Whelan Clare , author

Bibliographic description in the original language

Whelan C., Whelan A.O., Shuralev E., Kwok H.F., Hewinson G., Clarke J., Vordermeier H.M. Performance of the Enferplex TB assay with cattle in Great Britain and assessment of its suitability as a test to distinguish infected and vaccinated animals // Clin Vaccine Immunol. 2010. 17(5): 813-817. DOI: 10.1128/CVI.00489-09

Annotation

Our results indicate that the test has a relative sensitivity range of 77.0% to 86.5% at corresponding specificity levels of 100.0% to 77.6%. Comparison with the Bovigam gamma interferon antemortem test revealed that this serology test was significantly more sensitive at specificities above 97.9%, while the Bovigam test was, on average, about 10% more sensitive when the test specificity was set below 97%. Importantly, this serological multiplex assay does not react with sera from BCG-vaccinated calves and is therefore suitable as a DIVA test alongside BCG-based vaccine strategies.

Keywords

Mycobacterium bovis, BCG, cattle, Bovigam, gamma interferon, vaccination, multiplex, immunoassay

The name of the journal

CLIN VACCINE IMMUNOL

On-line resource for training course

http://dspace.kpfu.ru/xmlui/bitstream/handle/net/149793/F_Whelan_2010.pdf?sequence=1&isAllowed=y

URL

https://cvi.asm.org/content/17/5/813

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=35749&p_lang=2

Resource files

File name	Size (MB)	Format
F_Whelan_2010.pdf	0,08	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Shuralev Eduard Arkadevich	ru_RU
dc.contributor.author	Clarke John	ru_RU
dc.contributor.author	Hewinson Glyn	ru_RU
dc.contributor.author	Kwok Hang Fai	ru_RU
dc.contributor.author	Vordermeier H. Martin	ru_RU
dc.contributor.author	Whelan Adam O.	ru_RU
dc.contributor.author	Whelan Clare	ru_RU
dc.date.accessioned	2010-01-01T00:00:00Z	ru_RU
dc.date.available	2010-01-01T00:00:00Z	ru_RU
dc.date.issued	2010	ru_RU
dc.identifier.citation	Whelan C., Whelan A.O., Shuralev E., Kwok H.F., Hewinson G., Clarke J., Vordermeier H.M. Performance of the Enferplex TB assay with cattle in Great Britain and assessment of its suitability as a test to distinguish infected and vaccinated animals // Clin Vaccine Immunol. 2010. 17(5): 813-817. DOI: 10.1128/CVI.00489-09	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=35749&p_lang=2	ru_RU
dc.description.abstract	CLIN VACCINE IMMUNOL	ru_RU
dc.description.abstract	Our results indicate that the test has a relative sensitivity range of 77.0% to 86.5% at corresponding specificity levels of 100.0% to 77.6%. Comparison with the Bovigam gamma interferon antemortem test revealed that this serology test was significantly more sensitive at specificities above 97.9%, while the Bovigam test was, on average, about 10% more sensitive when the test specificity was set below 97%. Importantly, this serological multiplex assay does not react with sera from BCG-vaccinated calves and is therefore suitable as a DIVA test alongside BCG-based vaccine strategies.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Mycobacterium bovis	ru_RU
dc.subject	BCG	ru_RU
dc.subject	cattle	ru_RU
dc.subject	Bovigam	ru_RU
dc.subject	gamma interferon	ru_RU
dc.subject	vaccination	ru_RU
dc.subject	multiplex	ru_RU
dc.subject	immunoassay	ru_RU
dc.title	Performance of the Enferplex TB assay with cattle in Great Britain and assessment of its suitability as a test to distinguish infected and vaccinated animals	ru_RU
dc.type	Articles in international journals and collections	ru_RU