KFU. Card publication. Phase-transition thermodynamics of hydrazide drugs: Isoniazid and Iproniazid

KAZAN
FEDERAL UNIVERSITY

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PHASE-TRANSITION THERMODYNAMICS OF HYDRAZIDE DRUGS: ISONIAZID AND IPRONIAZID

Form of presentation

Articles in international journals and collections

Year of publication

2026

Язык

английский

Authors, employees of KFU

Bolmatenkov Dmitriy Nikolaevich, author

Nizamov Ilyas Ilnarovich, author

Notfullin Ayrat Albertovich, author

Sokolov Andrey Anatolevich, author

Solomonov Boris Nikolaevich, author

Khisamiev Mansur Bulatovich, author

Yagofarov Mikhail Iskanderovich, author

Bibliographic description in the original language

Notfullin AA, Bolmatenkov DN, Nizamov II, Phase-transition thermodynamics of hydrazide drugs: Isoniazid and Iproniazid//THERMOCHIMICA ACTA. - 2026. - Vol.759, Is.. - Art. №180277.

Annotation

In this work, we provide experimental values of phase transition thermodynamic parameters of two structurally similar drugs, pyridine-4-carbohydrazide (isoniazid) and N'-propan-2-ylpyridine-4-carbohydrazide (iproniazid), in a wide temperature range. Saturated vapor pressures above crystalline phases and sublimation enthalpies were measured using the thermogravimetry-fast scanning calorimetry (TG-FSC). The thermodynamics of fusion between 298.15 K and the melting point Tm was studied by a combination of differential scanning calorimetry (DSC) and solution calorimetry techniques. Heat capacities used for temperature corrections were determined as follows: the values for polymorphic form I of isoniazid and form II of iproniazid were measured by differential scanning calorimetry; supercooled liquid phase heat capacities were obtained using fast scanning calorimetry (FSC); and ideal gas phase heat capacities were calculated using quantum chemistry and statistical thermodynamics. Based on sublimation and melting data, thermodynamic parameters of vaporization were derived. The similarities and differences in phase transition thermodynamic properties of two drugs were discussed applying additivity-based approaches.

Keywords

Phase-transition thermodynamics, Isoniazid, Iproniazid

The name of the journal

THERMOCHIMICA ACTA

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=325259&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Bolmatenkov Dmitriy Nikolaevich	ru_RU
dc.contributor.author	Nizamov Ilyas Ilnarovich	ru_RU
dc.contributor.author	Notfullin Ayrat Albertovich	ru_RU
dc.contributor.author	Sokolov Andrey Anatolevich	ru_RU
dc.contributor.author	Solomonov Boris Nikolaevich	ru_RU
dc.contributor.author	Khisamiev Mansur Bulatovich	ru_RU
dc.contributor.author	Yagofarov Mikhail Iskanderovich	ru_RU
dc.date.accessioned	2026-01-01T00:00:00Z	ru_RU
dc.date.available	2026-01-01T00:00:00Z	ru_RU
dc.date.issued	2026	ru_RU
dc.identifier.citation	Notfullin AA, Bolmatenkov DN, Nizamov II, Phase-transition thermodynamics of hydrazide drugs: Isoniazid and Iproniazid//THERMOCHIMICA ACTA. - 2026. - Vol.759, Is.. - Art. №180277.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=325259&p_lang=2	ru_RU
dc.description.abstract	THERMOCHIMICA ACTA	ru_RU
dc.description.abstract	In this work, we provide experimental values of phase transition thermodynamic parameters of two structurally similar drugs, pyridine-4-carbohydrazide (isoniazid) and N'-propan-2-ylpyridine-4-carbohydrazide (iproniazid), in a wide temperature range. Saturated vapor pressures above crystalline phases and sublimation enthalpies were measured using the thermogravimetry-fast scanning calorimetry (TG-FSC). The thermodynamics of fusion between 298.15 K and the melting point Tm was studied by a combination of differential scanning calorimetry (DSC) and solution calorimetry techniques. Heat capacities used for temperature corrections were determined as follows: the values for polymorphic form I of isoniazid and form II of iproniazid were measured by differential scanning calorimetry; supercooled liquid phase heat capacities were obtained using fast scanning calorimetry (FSC); and ideal gas phase heat capacities were calculated using quantum chemistry and statistical thermodynamics. Based on sublimation and melting data, thermodynamic parameters of vaporization were derived. The similarities and differences in phase transition thermodynamic properties of two drugs were discussed applying additivity-based approaches.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Phase-transition thermodynamics	ru_RU
dc.subject	Isoniazid	ru_RU
dc.subject	Iproniazid	ru_RU
dc.title	Phase-transition thermodynamics of hydrazide drugs: Isoniazid and Iproniazid	ru_RU
dc.type	Articles in international journals and collections	ru_RU