KFU. Card publication. Joint Tissues: Convergence and Divergence of the Pathogenetic Mechanisms of Rheumatoid Arthritis and Osteoarthritis

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FEDERAL UNIVERSITY

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JOINT TISSUES: CONVERGENCE AND DIVERGENCE OF THE PATHOGENETIC MECHANISMS OF RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS

Form of presentation

Articles in international journals and collections

Year of publication

2025

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Authors, employees of KFU

Arleevskaya Marina Igorevna, author

Valeeva Anna Rafkatovna, author

Bibliographic description in the original language

Joint Tissues: Convergence and Divergence of the Pathogenetic Mechanisms of Rheumatoid Arthritis and Osteoarthritis / M. O. Korovina, A. R. Valeeva, I. F. Akhtyamov [et al.] // International Journal of Molecular Sciences. – 2025. – Vol. 26, No. 17. – P. 8742. – DOI 10.3390/ijms26178742. – EDN ENRGGW.

Annotation

Rheumatoid arthritis (RA) and osteoarthritis (OA) are frequently occurring multifactorial diseases affecting joints. OA and RA may share not only tissue locations but also some molecular mechanisms. We compared different pathologies: anti-cyclic citrullinated peptide antibody (ACCP)-positive RA—the classical 'antigen-driven' pathology, starting in synovia with no signs of inflammatory process; ACCP-negative RA, starting with synovial inflammation triggered by nonspecific factors, which becomes a chronic process due to inherited innate immune peculiarities; and OA, starting with inadequate chondrocyte functioning and cartilage degradation with inflammation as a driving force. Notable coincidences in RA and OA development were revealed: shared mutations of 29 genes encoding molecules involved in immune-inflammatory processes and in ECM production; unidirectional association of OA and ACCP-negative RA with non-genetic triggers; and overactivation of signaling pathways with the same consequences for RA and OA. Innate and adaptive immune responses were involved in OA development. Similar to that observed in RA, lymphoid nodular aggregates were revealed in 30% of OA synovia. Myeloid, and especially pauci-immune and fibroid synovial pathotypes, are possible in OA. Indistinguishable from that in RA, pannuses were found in OA articular tissues. Thus, these coincidences may be evidence of evolution of some OA variants in RA.

Keywords

Rheumatoid arthritis (RA), osteoarthritis (OA), molecular mechanisms.

The name of the journal

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

URL

https://www.mdpi.com/1422-0067/26/17/8742

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=324631&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Arleevskaya Marina Igorevna	ru_RU
dc.contributor.author	Valeeva Anna Rafkatovna	ru_RU
dc.date.accessioned	2025-01-01T00:00:00Z	ru_RU
dc.date.available	2025-01-01T00:00:00Z	ru_RU
dc.date.issued	2025	ru_RU
dc.identifier.citation	Joint Tissues: Convergence and Divergence of the Pathogenetic Mechanisms of Rheumatoid Arthritis and Osteoarthritis / M. O. Korovina, A. R. Valeeva, I. F. Akhtyamov [et al.] // International Journal of Molecular Sciences. – 2025. – Vol. 26, No. 17. – P. 8742. – DOI 10.3390/ijms26178742. – EDN ENRGGW.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=324631&p_lang=2	ru_RU
dc.description.abstract	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	ru_RU
dc.description.abstract	Rheumatoid arthritis (RA) and osteoarthritis (OA) are frequently occurring multifactorial diseases affecting joints. OA and RA may share not only tissue locations but also some molecular mechanisms. We compared different pathologies: anti-cyclic citrullinated peptide antibody (ACCP)-positive RA—the classical 'antigen-driven' pathology, starting in synovia with no signs of inflammatory process; ACCP-negative RA, starting with synovial inflammation triggered by nonspecific factors, which becomes a chronic process due to inherited innate immune peculiarities; and OA, starting with inadequate chondrocyte functioning and cartilage degradation with inflammation as a driving force. Notable coincidences in RA and OA development were revealed: shared mutations of 29 genes encoding molecules involved in immune-inflammatory processes and in ECM production; unidirectional association of OA and ACCP-negative RA with non-genetic triggers; and overactivation of signaling pathways with the same consequences for RA and OA. Innate and adaptive immune responses were involved in OA development. Similar to that observed in RA, lymphoid nodular aggregates were revealed in 30% of OA synovia. Myeloid, and especially pauci-immune and fibroid synovial pathotypes, are possible in OA. Indistinguishable from that in RA, pannuses were found in OA articular tissues. Thus, these coincidences may be evidence of evolution of some OA variants in RA.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Rheumatoid arthritis (RA)	ru_RU
dc.subject	osteoarthritis (OA)	ru_RU
dc.subject	molecular mechanisms.	ru_RU
dc.title	Joint Tissues: Convergence and Divergence of the Pathogenetic Mechanisms of Rheumatoid Arthritis and Osteoarthritis	ru_RU
dc.type	Articles in international journals and collections	ru_RU