KFU. Card publication. Morphological and Functional Evaluation of Rat Leg Muscles under the Influence of Hindlimb Unloading, Tenotomy, and Denervation. Biochem

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MORPHOLOGICAL AND FUNCTIONAL EVALUATION OF RAT LEG MUSCLES UNDER THE INFLUENCE OF HINDLIMB UNLOADING, TENOTOMY, AND DENERVATION. BIOCHEM

Form of presentation

Articles in international journals and collections

Year of publication

2026

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Authors, employees of KFU

Baltina Tatyana Valerevna, author

Eremeev Anton Aleksandrovich, author

Khayrullin Adel Evgenevich, author

Authors, postgraduates KFU

Sabirova Diana Emilevna, postgraduate kfu

Authors, students KFU

Shadrina Alena Aleksandrovna, author

Bibliographic description in the original language

Sabirova, D.E. Morphological and Functional Evaluation of Rat Leg Muscles under the Influence of Hindlimb Unloading, Tenotomy, and Denervation. Biochem / D.E.Sabirova, A.A.Shadrina, A.A. Eremeev, A. E. Khairullin, T. V. Baltina // Moscow Suppl. Ser. A. - 2026. - V. 20. - P. 89–102.

Annotation

Skeletal muscle atrophy can develop under the influence of various factors associated with their disuse, such as immobilization, denervation, or exposure to microgravity. The aim of the study was to conduct a morphological and functional assessment of the soleus, gastrocnemius, and tibialis anterior muscles in models of disuse in rats. The rats were randomly divided into a control group and groups subjected to denervation, tenotomy, and hindlimb unloading (HU). During the experiments, a decrease in muscle fiber diameter was observed in all experimental groups. Tenotomy resulted in a decrease in dystrophin immunoexpression. With HU, the level of dystrophin decreased, but by day 35, recovery was observed in the gastrocnemius and tibialis anterior muscles, while in the soleus muscle, the level continued to fall. After denervation, the dystrophin content also decreased but then increased, reaching control values in the soleus muscle by day 35. The level of neuronal NO synthase decreased significantly in all experimental groups. Denervation and tenotomy lead to pronounced changes in the contractile function of the soleus muscle in rats.

Keywords

muscle atrophy, dystrophin, neuronal NO synthase, hindlimb unloading, denervation tenotomy

The name of the journal

Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology

URL

https://link.springer.com/article/10.1134/S1990747825700606

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=323065&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Baltina Tatyana Valerevna	ru_RU
dc.contributor.author	Eremeev Anton Aleksandrovich	ru_RU
dc.contributor.author	Khayrullin Adel Evgenevich	ru_RU
dc.contributor.author	Shadrina Alena Aleksandrovna	ru_RU
dc.contributor.author	Sabirova Diana Emilevna	ru_RU
dc.date.accessioned	2026-01-01T00:00:00Z	ru_RU
dc.date.available	2026-01-01T00:00:00Z	ru_RU
dc.date.issued	2026	ru_RU
dc.identifier.citation	Sabirova, D.E. Morphological and Functional Evaluation of Rat Leg Muscles under the Influence of Hindlimb Unloading, Tenotomy, and Denervation. Biochem / D.E.Sabirova, A.A.Shadrina, A.A. Eremeev, A. E. Khairullin, T. V. Baltina // Moscow Suppl. Ser. A. - 2026. - V. 20. - P. 89–102.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=323065&p_lang=2	ru_RU
dc.description.abstract	Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology	ru_RU
dc.description.abstract	Skeletal muscle atrophy can develop under the influence of various factors associated with their disuse, such as immobilization, denervation, or exposure to microgravity. The aim of the study was to conduct a morphological and functional assessment of the soleus, gastrocnemius, and tibialis anterior muscles in models of disuse in rats. The rats were randomly divided into a control group and groups subjected to denervation, tenotomy, and hindlimb unloading (HU). During the experiments, a decrease in muscle fiber diameter was observed in all experimental groups. Tenotomy resulted in a decrease in dystrophin immunoexpression. With HU, the level of dystrophin decreased, but by day 35, recovery was observed in the gastrocnemius and tibialis anterior muscles, while in the soleus muscle, the level continued to fall. After denervation, the dystrophin content also decreased but then increased, reaching control values in the soleus muscle by day 35. The level of neuronal NO synthase decreased significantly in all experimental groups. Denervation and tenotomy lead to pronounced changes in the contractile function of the soleus muscle in rats.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	muscle atrophy	ru_RU
dc.subject	dystrophin	ru_RU
dc.subject	neuronal NO synthase	ru_RU
dc.subject	hindlimb unloading	ru_RU
dc.subject	denervation tenotomy	ru_RU
dc.title	Morphological and Functional Evaluation of Rat Leg Muscles under the Influence of Hindlimb Unloading, Tenotomy, and Denervation. Biochem	ru_RU
dc.type	Articles in international journals and collections	ru_RU