KFU. Card publication. nflammatory mediators in nasal secretion in patients with bronchial asthma and allergic rhinitis with or without polyposis and hypertrophic sinonasal mucosa

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NFLAMMATORY MEDIATORS IN NASAL SECRETION IN PATIENTS WITH BRONCHIAL ASTHMA AND ALLERGIC RHINITIS WITH OR WITHOUT POLYPOSIS AND HYPERTROPHIC SINONASAL MUCOSA

Form of presentation

Articles in international journals and collections

Year of publication

2025

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Authors, employees of KFU

Kubysheva Nailya Iskhakovna, author

Other authors

Eliseeva Tatyana , author

Geppe Natalia , author

Gorbunova Ksenia , author

Khramova Regina , author

Krasilnikova Svetlana , author

Krestova Ekaterina , author

Leontieva Elena , author

Ovsyannikov Dmitry , author

Bibliographic description in the original language

Krasilnikova S. V., Krestova E. I., Eliseeva T. I., Khramova R. N., Gorbunova K. V., Leontieva E. A., Ovsyannikov D.Yu., Geppe N.A., Kubysheva N. I. (2025). Inflammatory mediators in nasal secretion in patients with bronchial asthma and allergic rhinitis with or without polyposis and hypertrophic sinonasal mucosa. Exploration of Medicine, 6, 1001306.

Annotation

Aim: The pathogenetic mechanisms and predictors of the development of polyposis and hypertrophy of the sinonasal mucosa (SM) in patients with chronic allergic airway inflammation have not been clearly established. The concentration of inflammatory biomarkers in nasal secretions was determined in children and adolescents with a combined course of bronchial asthma (BA) and allergic rhinitis (AR) in the absence or presence of polyposis and hypertrophy of the SM. Methods: A single-centre observational cross-sectional pilot study was conducted. 93 patients with BA aged 8 to 17 years were studied. Total Nasal Symptom Score (TNSS), sinonasal symptoms (SNOT-22), and peak nasal inspiratory flow (PNIF) were assessed. Concentrations of eosinophil cationic protein (ECP), interleukin 4 (IL-4), IL-1, total immunoglobulin E (IgE), and vascular endothelial growth factor (VEGF) in nasal secretions were determined. Results: The levels of ECP, IL-4, and IL-1 in nasal secretions were statistically significantly higher in patients with the presence of polyposis and hypertrophic SM than in those without, amounting to 83.1 [31.4; 166.8] ng/mL for ECP vs. 29.5 [5.3; 49.9] ng/mL, P < 0.001, for IL-4 174.6 [68.6; 325.5] pg/mL vs. 79.5 [42.8; 146.01] pg/mL, P = 0.004, for IL-1 98.7 [33.7; 267.5] pg/mL and 48.8 [9.01; 108.2] pg/mL, P = 0.025. There were no statistically significant differences in IgE and VEGF levels in nasal secretions, all P > 0.05. Parameters such as ECP, IL-4, and IL-1 were found to be significant predictors of polyposis and hypertrophy in the formation of SM. Conclusions: In patients with a combined course of BA and AR, the presence of polyposis and hypertrophy of SM is associated with higher levels of ECP, IL-4, and IL-1 in nasal secretion. This may indicate that pathological remodelling of SM is associated with both the intensity of allergic inflammation and its relationship with local activation of innate immunity.

Keywords

Bronchial asthma, allergic rhinitis, children, adolescents, polyps, biomarkers

The name of the journal

Exploration of Medicine

URL

https://www.explorationpub.com/Journals/em/Article/1001306

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=322045&p_lang=2

Resource files

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Inflammatory_mediators_in_nasal_secretion_in_patients_with_BA.pdf	2,25	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kubysheva Nailya Iskhakovna	ru_RU
dc.contributor.author	Eliseeva Tatyana	ru_RU
dc.contributor.author	Geppe Natalia	ru_RU
dc.contributor.author	Gorbunova Ksenia	ru_RU
dc.contributor.author	Khramova Regina	ru_RU
dc.contributor.author	Krasilnikova Svetlana	ru_RU
dc.contributor.author	Krestova Ekaterina	ru_RU
dc.contributor.author	Leontieva Elena	ru_RU
dc.contributor.author	Ovsyannikov Dmitry	ru_RU
dc.date.accessioned	2025-01-01T00:00:00Z	ru_RU
dc.date.available	2025-01-01T00:00:00Z	ru_RU
dc.date.issued	2025	ru_RU
dc.identifier.citation	Krasilnikova S. V., Krestova E. I., Eliseeva T. I., Khramova R. N., Gorbunova K. V., Leontieva E. A., Ovsyannikov D.Yu., Geppe N.A., Kubysheva N. I. (2025). Inflammatory mediators in nasal secretion in patients with bronchial asthma and allergic rhinitis with or without polyposis and hypertrophic sinonasal mucosa. Exploration of Medicine, 6, 1001306.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=322045&p_lang=2	ru_RU
dc.description.abstract	Exploration of Medicine	ru_RU
dc.description.abstract	Aim: The pathogenetic mechanisms and predictors of the development of polyposis and hypertrophy of the sinonasal mucosa (SM) in patients with chronic allergic airway inflammation have not been clearly established. The concentration of inflammatory biomarkers in nasal secretions was determined in children and adolescents with a combined course of bronchial asthma (BA) and allergic rhinitis (AR) in the absence or presence of polyposis and hypertrophy of the SM. Methods: A single-centre observational cross-sectional pilot study was conducted. 93 patients with BA aged 8 to 17 years were studied. Total Nasal Symptom Score (TNSS), sinonasal symptoms (SNOT-22), and peak nasal inspiratory flow (PNIF) were assessed. Concentrations of eosinophil cationic protein (ECP), interleukin 4 (IL-4), IL-1, total immunoglobulin E (IgE), and vascular endothelial growth factor (VEGF) in nasal secretions were determined. Results: The levels of ECP, IL-4, and IL-1 in nasal secretions were statistically significantly higher in patients with the presence of polyposis and hypertrophic SM than in those without, amounting to 83.1 [31.4; 166.8] ng/mL for ECP vs. 29.5 [5.3; 49.9] ng/mL, P < 0.001, for IL-4 174.6 [68.6; 325.5] pg/mL vs. 79.5 [42.8; 146.01] pg/mL, P = 0.004, for IL-1 98.7 [33.7; 267.5] pg/mL and 48.8 [9.01; 108.2] pg/mL, P = 0.025. There were no statistically significant differences in IgE and VEGF levels in nasal secretions, all P > 0.05. Parameters such as ECP, IL-4, and IL-1 were found to be significant predictors of polyposis and hypertrophy in the formation of SM. Conclusions: In patients with a combined course of BA and AR, the presence of polyposis and hypertrophy of SM is associated with higher levels of ECP, IL-4, and IL-1 in nasal secretion. This may indicate that pathological remodelling of SM is associated with both the intensity of allergic inflammation and its relationship with local activation of innate immunity.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Bronchial asthma	ru_RU
dc.subject	allergic rhinitis	ru_RU
dc.subject	children	ru_RU
dc.subject	adolescents	ru_RU
dc.subject	polyps	ru_RU
dc.subject	biomarkers	ru_RU
dc.title	nflammatory mediators in nasal secretion in patients with bronchial asthma and allergic rhinitis with or without polyposis and hypertrophic sinonasal mucosa	ru_RU
dc.type	Articles in international journals and collections	ru_RU