KFU. Card publication. Impact of BMI on IL-6 and IL-18 levels in children and adolescents with asthma.

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FEDERAL UNIVERSITY

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IMPACT OF BMI ON IL-6 AND IL-18 LEVELS IN CHILDREN AND ADOLESCENTS WITH ASTHMA.

Form of presentation

Articles in international journals and collections

Year of publication

2025

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Authors, employees of KFU

Kubysheva Nailya Iskhakovna, author

Other authors

Eliseeva Tatyana , author

Geppe Natalia , author

Karpenko Maxim , author

Khaletskaya Olga , author

Khramova Regina , author

Krasilnikova Svetlana , author

Ovsyannikov Dmitry , author

Tush Elena , author

Bibliographic description in the original language

Khramova R. N., Tush E. V., Eliseeva T. I., Ovsyannikov D. Y., Krasilnikova S. V., Karpenko M. A., Geppe N. A., Kubysheva N. I., Khaletskaya O. V. (2025). Impact of BMI on IL-6 and IL-18 levels in children and adolescents with asthma. Exploration of Medicine, 6, 1001338.

Annotation

Aim: To study the effect of body mass index (BMI) on interleukin (IL)-6 and IL-18 levels in children and adolescents with bronchial asthma (BA), taking into account the presence or absence of bronchial obstruction. Methods: A single-center observational cross-sectional pilot study was conducted. Eighty-six patients with BA aged from 8 to 17 years were studied. Anthropometric and spirometric parameters and IL-6, IL-18 levels were assessed. The study participants were divided into 2 groups: 1—patients with normal body weight (BW), 2—overweight/obese. Results: The serum levels of IL-6 and IL-18 were statistically significantly higher in overweight/obese patients than in normal BW patients, being 1.18 [0.10; 3.27] pg/mL vs. 0.52 [0.10; 1.34] pg/mL, P = 0.036 and 251.0 [207.0; 346.0] pg/mL vs. 208.0 [134.0; 293.0] pg/mL, P = 0.012, respectively. Statistically significant direct correlations of IL-6 and IL-18 with z BMI were obtained in the total group: R = 0.35, P = 0.001; R = 0.37, P = 0.002, respectively. In the overweight/obese group, IL-6 and IL-18 levels were statistically significantly higher in patients with obstruction [z forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) < –1.645 z] than in patients without obstruction (z FEV1/FVC > –1.645 z), respectively: 1.74 [1.10; 5.41] pg/mL vs. 0.59 [0.50; 1.48] pg/mL, P = 0.026 for IL-6 and 298.50 [207.00; 425.00] pg/mL vs. 234.50 [207.00; 300.00] pg/mL, P = 0.046 for IL-18. Conclusions: In patients with BA and overweight/obese, but not in patients with BA and normal BW, the presence of bronchial obstruction is associated with higher serum levels of IL-6, IL-18. This may indicate the involvement of these ILs in the genesis of bronchial obstruction in patients with BA and overweight/obese.

Keywords

Asthma, children, overweight, obesity, IL-6, IL-18

The name of the journal

Exploration of Medicine

URL

https://www.explorationpub.com/Journals/em/Article/1001338

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=322044&p_lang=2

Resource files

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F_Impact_of_BMI_on_IL_6_and_IL_18_levels_in_children_and_adolescents.pdf	1,49	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kubysheva Nailya Iskhakovna	ru_RU
dc.contributor.author	Eliseeva Tatyana	ru_RU
dc.contributor.author	Geppe Natalia	ru_RU
dc.contributor.author	Karpenko Maxim	ru_RU
dc.contributor.author	Khaletskaya Olga	ru_RU
dc.contributor.author	Khramova Regina	ru_RU
dc.contributor.author	Krasilnikova Svetlana	ru_RU
dc.contributor.author	Ovsyannikov Dmitry	ru_RU
dc.contributor.author	Tush Elena	ru_RU
dc.date.accessioned	2025-01-01T00:00:00Z	ru_RU
dc.date.available	2025-01-01T00:00:00Z	ru_RU
dc.date.issued	2025	ru_RU
dc.identifier.citation	Khramova R. N., Tush E. V., Eliseeva T. I., Ovsyannikov D. Y., Krasilnikova S. V., Karpenko M. A., Geppe N. A., Kubysheva N. I., Khaletskaya O. V. (2025). Impact of BMI on IL-6 and IL-18 levels in children and adolescents with asthma. Exploration of Medicine, 6, 1001338.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=322044&p_lang=2	ru_RU
dc.description.abstract	Exploration of Medicine	ru_RU
dc.description.abstract	Aim: To study the effect of body mass index (BMI) on interleukin (IL)-6 and IL-18 levels in children and adolescents with bronchial asthma (BA), taking into account the presence or absence of bronchial obstruction. Methods: A single-center observational cross-sectional pilot study was conducted. Eighty-six patients with BA aged from 8 to 17 years were studied. Anthropometric and spirometric parameters and IL-6, IL-18 levels were assessed. The study participants were divided into 2 groups: 1—patients with normal body weight (BW), 2—overweight/obese. Results: The serum levels of IL-6 and IL-18 were statistically significantly higher in overweight/obese patients than in normal BW patients, being 1.18 [0.10; 3.27] pg/mL vs. 0.52 [0.10; 1.34] pg/mL, P = 0.036 and 251.0 [207.0; 346.0] pg/mL vs. 208.0 [134.0; 293.0] pg/mL, P = 0.012, respectively. Statistically significant direct correlations of IL-6 and IL-18 with z BMI were obtained in the total group: R = 0.35, P = 0.001; R = 0.37, P = 0.002, respectively. In the overweight/obese group, IL-6 and IL-18 levels were statistically significantly higher in patients with obstruction [z forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) < –1.645 z] than in patients without obstruction (z FEV1/FVC > –1.645 z), respectively: 1.74 [1.10; 5.41] pg/mL vs. 0.59 [0.50; 1.48] pg/mL, P = 0.026 for IL-6 and 298.50 [207.00; 425.00] pg/mL vs. 234.50 [207.00; 300.00] pg/mL, P = 0.046 for IL-18. Conclusions: In patients with BA and overweight/obese, but not in patients with BA and normal BW, the presence of bronchial obstruction is associated with higher serum levels of IL-6, IL-18. This may indicate the involvement of these ILs in the genesis of bronchial obstruction in patients with BA and overweight/obese.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Asthma	ru_RU
dc.subject	children	ru_RU
dc.subject	overweight	ru_RU
dc.subject	obesity	ru_RU
dc.subject	IL-6	ru_RU
dc.subject	IL-18	ru_RU
dc.title	Impact of BMI on IL-6 and IL-18 levels in children and adolescents with asthma.	ru_RU
dc.type	Articles in international journals and collections	ru_RU