KFU. Card publication. Shapes and dimensions of blood clots affect the rate and extent of platelet-driven clot contraction and determine the outcomes of thrombosis

- RUS
- 中文
- ES

SHAPES AND DIMENSIONS OF BLOOD CLOTS AFFECT THE RATE AND EXTENT OF PLATELET-DRIVEN CLOT CONTRACTION AND DETERMINE THE OUTCOMES OF THROMBOSIS

Form of presentation

Articles in international journals and collections

Year of publication

2026

��

��

Authors, employees of KFU

Salyakhutdinova Shakhnoza Matmuradovna, author

Khabirova Alina Ilshatovna, author

Khismatullin Rafael Rafikovich, author

Other authors

Weisel John W., author

Litvinov Rustem Igorevich, author

Authors, postgraduates KFU

Salyakhutdinova Shakhnoza Matmuradovna, postgraduate kfu

Bibliographic description in the original language

Khismatullin, R. R., Khabirova, A. I., Saliakhutdinova, S. M., Litvinov, R. I., & Weisel, J. W. (2026). Shapes and dimensions of blood clots affect the rate and extent of platelet-driven clot contraction and determine the outcomes of thrombosis. Journal of thrombosis and haemostasis : JTH, S1538-7836(25)00597-5. Advance online publication. https://doi.org/10.1016/j.jtha.2025.09.007

Annotation

Background Contraction of blood clots has multiple pathophysiological implications. Objectives To determine whether the initial shape and dimensions of blood clots affect clot contraction. Methods Thrombin-induced clots of various sizes were formed in human blood or platelet-rich plasma in a cylinder, cuboid, or flat chamber. Clot shrinkage was tracked photographically. After complete contraction, the physiologically most relevant cylindrical clots of various initial volumes were analyzed with scanning electron microscopy for composition and spatial nonuniformity with the emphasis on compressed polyhedral erythrocytes (polyhedrocytes). Results With the same volumes studied, the final extents of contraction of 0.3-mL whole blood clots were shape-dependent, such that flat was more contracted than cylindrical, which was equal to cuboid. Irrespective of the shape, the smaller clots mainly contracted to a larger extent. Unlike whole blood clots, platelet-rich plasma clots contracted independently of the clot volumes and shapes studied, indicating a key role of erythrocytes. The smaller blood clots contained more erythrocytes, especially polyhedrocytes, due to tight packing and a decrease in the intercellular space. The spatial segregation within the larger clots was less marked than in the smaller clots, reflecting incomplete spatial redistribution of blood clot components typical for robust contraction. Conclusion Contraction of blood clots depends on their shape and size. The smaller and larger clots have distinct size-dependent rates and extents of contraction as well as degrees of structural nonuniformity, reflecting different spatial gradients of compressive stresses. These findings are relevant to the variable geometry and size of intravascular blood clots and thrombi.

Keywords

blood clot, blood platelets, clot retraction, erythrocytes, thrombosis

The name of the journal

JOURNAL OF THROMBOSIS AND HAEMOSTASIS

URL

https://www.sciencedirect.com/science/article/pii/S1538783625005975

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=321771&p_lang=2

Resource files

File name	Size (MB)	Format
1_s2.0_S1538783625005975_main.pdf	3,98	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Salyakhutdinova Shakhnoza Matmuradovna	ru_RU
dc.contributor.author	Khabirova Alina Ilshatovna	ru_RU
dc.contributor.author	Khismatullin Rafael Rafikovich	ru_RU
dc.contributor.author	Weisel John W.	ru_RU
dc.contributor.author	Litvinov Rustem Igorevich	ru_RU
dc.contributor.author	Salyakhutdinova Shakhnoza Matmuradovna	ru_RU
dc.date.accessioned	2026-01-01T00:00:00Z	ru_RU
dc.date.available	2026-01-01T00:00:00Z	ru_RU
dc.date.issued	2026	ru_RU
dc.identifier.citation	Khismatullin, R. R., Khabirova, A. I., Saliakhutdinova, S. M., Litvinov, R. I., & Weisel, J. W. (2026). Shapes and dimensions of blood clots affect the rate and extent of platelet-driven clot contraction and determine the outcomes of thrombosis. Journal of thrombosis and haemostasis : JTH, S1538-7836(25)00597-5. Advance online publication. https://doi.org/10.1016/j.jtha.2025.09.007	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=321771&p_lang=2	ru_RU
dc.description.abstract	JOURNAL OF THROMBOSIS AND HAEMOSTASIS	ru_RU
dc.description.abstract	Background Contraction of blood clots has multiple pathophysiological implications. Objectives To determine whether the initial shape and dimensions of blood clots affect clot contraction. Methods Thrombin-induced clots of various sizes were formed in human blood or platelet-rich plasma in a cylinder, cuboid, or flat chamber. Clot shrinkage was tracked photographically. After complete contraction, the physiologically most relevant cylindrical clots of various initial volumes were analyzed with scanning electron microscopy for composition and spatial nonuniformity with the emphasis on compressed polyhedral erythrocytes (polyhedrocytes). Results With the same volumes studied, the final extents of contraction of 0.3-mL whole blood clots were shape-dependent, such that flat was more contracted than cylindrical, which was equal to cuboid. Irrespective of the shape, the smaller clots mainly contracted to a larger extent. Unlike whole blood clots, platelet-rich plasma clots contracted independently of the clot volumes and shapes studied, indicating a key role of erythrocytes. The smaller blood clots contained more erythrocytes, especially polyhedrocytes, due to tight packing and a decrease in the intercellular space. The spatial segregation within the larger clots was less marked than in the smaller clots, reflecting incomplete spatial redistribution of blood clot components typical for robust contraction. Conclusion Contraction of blood clots depends on their shape and size. The smaller and larger clots have distinct size-dependent rates and extents of contraction as well as degrees of structural nonuniformity, reflecting different spatial gradients of compressive stresses. These findings are relevant to the variable geometry and size of intravascular blood clots and thrombi.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	blood clot	ru_RU
dc.subject	blood platelets	ru_RU
dc.subject	clot retraction	ru_RU
dc.subject	erythrocytes	ru_RU
dc.subject	thrombosis	ru_RU
dc.title	Shapes and dimensions of blood clots affect the rate and extent of platelet-driven clot contraction and determine the outcomes of thrombosis	ru_RU
dc.type	Articles in international journals and collections	ru_RU