KFU. Card publication. Blood Levels and Composition of Leukocyte-Platelet Aggregates in Inflammatory Diseases of Various Etiologies

KAZAN
FEDERAL UNIVERSITY

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BLOOD LEVELS AND COMPOSITION OF LEUKOCYTE-PLATELET AGGREGATES IN INFLAMMATORY DISEASES OF VARIOUS ETIOLOGIES

Form of presentation

Articles in international journals and collections

Year of publication

2025

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Authors, employees of KFU

Salyakhutdinova Shakhnoza Matmuradovna, author

Other authors

Weisel John W., author

Andrianova Izabella Aleksandrovna, author

Litvinov Rustem Igorevich, author

Peshkova Alina Dmitrievna, author

Authors, postgraduates KFU

Salyakhutdinova Shakhnoza Matmuradovna, postgraduate kfu

Authors, students KFU

Sunbuli Khetam , author

Bibliographic description in the original language

Peshkova AD, Saliakhutdinova SM, Sounbuli K, Andrianova IA, Litvinov RI, Weisel JW. Blood Levels and Composition of Leukocyte-Platelet Aggregates in Inflammatory Diseases of Various Etiologies. Thromb Haemost. 2025 Dec 4. doi: 10.1055/a-2742-3449. Epub ahead of print. PMID: 41224208.

Annotation

Thrombosis and haemostasis

Keywords

leukocyte-platelet aggregates, neutrophils, monocytes, platelets, COVID-19, system lupus erythematosus, rheumatoid arthritis

The name of the journal

Thrombosis and haemostasis

URL

https://pubmed.ncbi.nlm.nih.gov/41224208/

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=321753&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Salyakhutdinova Shakhnoza Matmuradovna	ru_RU
dc.contributor.author	Weisel John W.	ru_RU
dc.contributor.author	Andrianova Izabella Aleksandrovna	ru_RU
dc.contributor.author	Litvinov Rustem Igorevich	ru_RU
dc.contributor.author	Peshkova Alina Dmitrievna	ru_RU
dc.contributor.author	Sunbuli Khetam	ru_RU
dc.contributor.author	Salyakhutdinova Shakhnoza Matmuradovna	ru_RU
dc.date.accessioned	2025-01-01T00:00:00Z	ru_RU
dc.date.available	2025-01-01T00:00:00Z	ru_RU
dc.date.issued	2025	ru_RU
dc.identifier.citation	Peshkova AD, Saliakhutdinova SM, Sounbuli K, Andrianova IA, Litvinov RI, Weisel JW. Blood Levels and Composition of Leukocyte-Platelet Aggregates in Inflammatory Diseases of Various Etiologies. Thromb Haemost. 2025 Dec 4. doi: 10.1055/a-2742-3449. Epub ahead of print. PMID: 41224208.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=321753&p_lang=2	ru_RU
dc.description.abstract	Thrombosis and haemostasis	ru_RU
dc.description.abstract	Leukocyte-platelet aggregates (LPAs) play a crucial role in the pathogenesis of inflammatory diseases, linking pathological immune responses with thrombosis.The levels of LPAs, their composition, and cellular reactivity were determined in patients with distinct inflammatory conditions, namely coronavirus disease 2019 (COVID-19), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE), compared with healthy controls. Flow cytometry was used to identify cell types and measure LPA levels in the blood. The ability of platelets, neutrophils, and monocytes to form additional LPAs in response to hyperstimulation with phorbol-12-myristate-13-acetate (PMA) was assessed. Coaggregation of isolated neutrophils and platelets in vitro was visualized using scanning electron microscopy. Blood tests included coagulation, hematology, biochemistry, and immunology.LPA levels were significantly higher in all patient groups compared with controls, with variations in the composition: neutrophil-platelet aggregates predominated in the COVID-19 patients, whereas monocyte-platelet aggregates prevailed in the blood of RA and SLE patients. Platelet-to-leukocyte ratios within aggregates varied in a broad range with a substantial prevalence of platelets over leukocytes. Morphological analysis revealed coaggregation of platelets with neutrophils, including relatively large homotypic platelet aggregates associated with one or two neutrophils. In PMA-treated pathological blood samples from COVID-19, RA, and SLE patients, the ability to form additional LPAs over the patients' baseline level was reduced compared with normal blood samples, indicating impaired reactivity (exhaustion) of neutrophils and monocytes in all patient groups.This study highlights distinct changes in the number and composition of LPAs in inflammatory diseases of various etiologies associated with altered functionality of the innate immune cells.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	leukocyte-platelet aggregates	ru_RU
dc.subject	neutrophils	ru_RU
dc.subject	monocytes	ru_RU
dc.subject	platelets	ru_RU
dc.subject	COVID-19	ru_RU
dc.subject	system lupus erythematosus	ru_RU
dc.subject	rheumatoid arthritis	ru_RU
dc.title	Blood Levels and Composition of Leukocyte-Platelet Aggregates in Inflammatory Diseases of Various Etiologies	ru_RU
dc.type	Articles in international journals and collections	ru_RU