KFU. Card publication. Adaptation of the Phytopathogenic Fungus Microdochium nivale to the Fungicides Tebuconazole and Fludioxonil.

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FEDERAL UNIVERSITY

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ADAPTATION OF THE PHYTOPATHOGENIC FUNGUS MICRODOCHIUM NIVALE TO THE FUNGICIDES TEBUCONAZOLE AND FLUDIOXONIL.

Form of presentation

Articles in Russian journals and collections

Year of publication

2025

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Authors, employees of KFU

Ponomareva Mira Leonidovna, author

Bibliographic description in the original language

Gogoleva, O.A., Murzagulova, G.S.; Ryazanov, E.A., Antonova, M.I., Lebedeva, A.A., Ponomarev, S.N., Ponomareva, M.L., Gorshkov, V.Y. Adaptation of the Phytopathogenic Fungus Microdochium nivale to the Fungicides Tebuconazole and Fludioxonil. // J. Fungi 2025. V.11. p.859.

Annotation

The study investigated the adaptation of the snow mold causal fungus, Microdochium nivale, to the fungicides fludioxonil and tebuconazole. Analysis of intrapopulation diversity among 136 M. nivale strains from two Russian populations revealed no strains with highlevel resistance to these fungicides. However, the strains exhibited considerable variability in their sensitivity to small fungicide doses. Fungicide sensitivity levels were not associated with virulence levels, whereas strains from different phylogenetic groups exhibited different predispositions to decreased sensitivity to tebuconazole and fludioxonil. In vitro adaptation experiments were conducted to assess: (1) the potential ability of M. nivale to acquire highlevel resistance to these fungicides; (2) the relative adaptation efficiency to each fungicide; and (3) the impact of resistance acquisition on virulence. Our results showed that M. nivale strains could adapt to high concentrations of both fungicides with little or no effect on virulence. Adaptation to fludioxonil was significantly less effective than to tebuconazole. To get closer to understanding the mechanisms of fludioxonil adaptation in M. nivale, whole-genome sequencing was performed on a fludioxonil-adapted derivative and its parental fludioxonil-sensitive strain. Comparative genome analysis identified mutations potentially involved in the enhanced fludioxonil resistance, which are discussed within the framework of molecular resistance mechanisms.

Keywords

fungicide resistance; intrapopulation heterogeneity of phytopathogenic fungi; Microdochium nivale; snow mold; virulence; stress-induced genome modification; plant infectious diseases

The name of the journal

Journal Fungi

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=321700&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Ponomareva Mira Leonidovna	ru_RU
dc.date.accessioned	2025-01-01T00:00:00Z	ru_RU
dc.date.available	2025-01-01T00:00:00Z	ru_RU
dc.date.issued	2025	ru_RU
dc.identifier.citation	Gogoleva, O.A., Murzagulova, G.S.; Ryazanov, E.A., Antonova, M.I., Lebedeva, A.A., Ponomarev, S.N., Ponomareva, M.L., Gorshkov, V.Y. Adaptation of the Phytopathogenic Fungus Microdochium nivale to the Fungicides Tebuconazole and Fludioxonil. // J. Fungi 2025. V.11. p.859.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=321700&p_lang=2	ru_RU
dc.description.abstract	Journal Fungi	ru_RU
dc.description.abstract	The study investigated the adaptation of the snow mold causal fungus, Microdochium nivale, to the fungicides fludioxonil and tebuconazole. Analysis of intrapopulation diversity among 136 M. nivale strains from two Russian populations revealed no strains with highlevel resistance to these fungicides. However, the strains exhibited considerable variability in their sensitivity to small fungicide doses. Fungicide sensitivity levels were not associated with virulence levels, whereas strains from different phylogenetic groups exhibited different predispositions to decreased sensitivity to tebuconazole and fludioxonil. In vitro adaptation experiments were conducted to assess: (1) the potential ability of M. nivale to acquire highlevel resistance to these fungicides; (2) the relative adaptation efficiency to each fungicide; and (3) the impact of resistance acquisition on virulence. Our results showed that M. nivale strains could adapt to high concentrations of both fungicides with little or no effect on virulence. Adaptation to fludioxonil was significantly less effective than to tebuconazole. To get closer to understanding the mechanisms of fludioxonil adaptation in M. nivale, whole-genome sequencing was performed on a fludioxonil-adapted derivative and its parental fludioxonil-sensitive strain. Comparative genome analysis identified mutations potentially involved in the enhanced fludioxonil resistance, which are discussed within the framework of molecular resistance mechanisms.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Adaptation of the Phytopathogenic Fungus Microdochium nivale to the Fungicides Tebuconazole and Fludioxonil.	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU