KFU. Card publication. Polymorphism and Phase-Transition Thermodynamic Properties of Phenazone (Antipyrine)

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FEDERAL UNIVERSITY

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POLYMORPHISM AND PHASE-TRANSITION THERMODYNAMIC PROPERTIES OF PHENAZONE (ANTIPYRINE)

Form of presentation

Articles in international journals and collections

Year of publication

2025

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Authors, employees of KFU

Bolmatenkov Dmitriy Nikolaevich, author

Nizamov Ilyas Ilnarovich, author

Notfullin Ayrat Albertovich, author

Sokolov Andrey Anatolevich, author

Solomonov Boris Nikolaevich, author

Yagofarov Mikhail Iskanderovich, author

Bibliographic description in the original language

Bolmatenkov D.N, Nizamov I.I, Sokolov A.A, Notfullin A.A., Solomonov B.N., Yagofarov M.I. Polymorphism and Phase-Transition Thermodynamic Properties of Phenazone (Antipyrine) // Molecules. - 2025. - Vol.30, Is.13. - Art. �2814.

Annotation

In this work, detailed information on the phase-transition thermodynamics of the analgesic and antipyretic drug phenazone, also known as antipyrine, is reported. It was found that the compound forms two polymorphs. Fusion thermodynamics of both forms was studied between 298.15 K and Tm using the combination of differential scanning calorimetry and solution calorimetry. The vapor pressures above crystalline and liquid phenazone were measured for the first time using thermogravimetry-fast scanning calorimetry technique. These studies were complemented by computation of the ideal gas entropy and heat capacity and by measurements of the condensed phase heat capacities. On the basis of experiments performed, we derived sublimation and vaporization enthalpies and vapor pressure above liquid and both crystalline modifications of phenazone in a wide range of temperatures.

Keywords

antipyrine, differential scanning calorimetry, fast scanning calorimetry, fusion enthalpy, heat capacity, phenazone, polymorphism, solution calorimetry, vapor pressure

The name of the journal

Molecules

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-105010233924&doi=10.3390%2fmolecules30132814&partnerID=40&md5=b0d13d21b61b46d01b81107e6583386a

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=319453&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Bolmatenkov Dmitriy Nikolaevich	ru_RU
dc.contributor.author	Nizamov Ilyas Ilnarovich	ru_RU
dc.contributor.author	Notfullin Ayrat Albertovich	ru_RU
dc.contributor.author	Sokolov Andrey Anatolevich	ru_RU
dc.contributor.author	Solomonov Boris Nikolaevich	ru_RU
dc.contributor.author	Yagofarov Mikhail Iskanderovich	ru_RU
dc.date.accessioned	2025-01-01T00:00:00Z	ru_RU
dc.date.available	2025-01-01T00:00:00Z	ru_RU
dc.date.issued	2025	ru_RU
dc.identifier.citation	Bolmatenkov D.N, Nizamov I.I, Sokolov A.A, Notfullin A.A., Solomonov B.N., Yagofarov M.I. Polymorphism and Phase-Transition Thermodynamic Properties of Phenazone (Antipyrine) // Molecules. - 2025. - Vol.30, Is.13. - Art. �2814.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=319453&p_lang=2	ru_RU
dc.description.abstract	Molecules	ru_RU
dc.description.abstract	In this work, detailed information on the phase-transition thermodynamics of the analgesic and antipyretic drug phenazone, also known as antipyrine, is reported. It was found that the compound forms two polymorphs. Fusion thermodynamics of both forms was studied between 298.15 K and Tm using the combination of differential scanning calorimetry and solution calorimetry. The vapor pressures above crystalline and liquid phenazone were measured for the first time using thermogravimetry-fast scanning calorimetry technique. These studies were complemented by computation of the ideal gas entropy and heat capacity and by measurements of the condensed phase heat capacities. On the basis of experiments performed, we derived sublimation and vaporization enthalpies and vapor pressure above liquid and both crystalline modifications of phenazone in a wide range of temperatures.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	antipyrine	ru_RU
dc.subject	differential scanning calorimetry	ru_RU
dc.subject	fast scanning calorimetry	ru_RU
dc.subject	fusion enthalpy	ru_RU
dc.subject	heat capacity	ru_RU
dc.subject	phenazone	ru_RU
dc.subject	polymorphism	ru_RU
dc.subject	solution calorimetry	ru_RU
dc.subject	vapor pressure	ru_RU
dc.title	Polymorphism and Phase-Transition Thermodynamic Properties of Phenazone (Antipyrine)	ru_RU
dc.type	Articles in international journals and collections	ru_RU