KFU. Card publication. Racemic 2-butanol, 2-ethylhexanol and malic ester in the synthesis of ammonium and hexadecylammonium dithiophosphonates with antimicrobial and cytotoxic activity

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RACEMIC 2-BUTANOL, 2-ETHYLHEXANOL AND MALIC ESTER IN THE SYNTHESIS OF AMMONIUM AND HEXADECYLAMMONIUM DITHIOPHOSPHONATES WITH ANTIMICROBIAL AND CYTOTOXIC ACTIVITY

Form of presentation

Articles in international journals and collections

Year of publication

2025

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Authors, employees of KFU

Nizamov Ilnar Damirovich, author

Nizamov Ilyas Saidovich, author

Salikhov Ramazan Zaytunovich, author

Authors, postgraduates KFU

Yakimov Vladimir Yurevich, postgraduate kfu

Authors, students KFU

Kalekulin Ivan Ilich, author

Bibliographic description in the original language

Nizamov, I.S. Racemic 2-butanol, 2-ethylhexanol and malic ester in the synthesis of ammonium and hexadecylammonium dithiophosphonates with antimicrobial and cytotoxic activity / I.S. Nizamov, V.Yu. Yakimov, I.I. Kalekulin, I.D. Nizamov, R.Z. Salikhov, K.A. Ivshin, O.N. Kataeva, G.G. Garifzianova, D.Yu. Grishaev, M.P. Shulaeva, A.A. Parfenov, A.B. Vyshtakalyuk // J. Sulfur Chem. – 2025. – Vol., Is.. – P.1–19. (ISSN: 1741-5993 (Print) 1741-6000 (Online) Journal homepage: www.tandfonline.com/journals/gsrp20) DOI 10.1080/17415993.2025.2551759. WoS, Q3

Annotation

Dithiophosphonic acids were prepared by the reactions of Lawesson's reagent with racemic 2-butanol, 2-ethylhexanol and diethyl malate reacted with ammonia and hexade- cylamine to form ammonium and hexadecylammonium dithiophosphonates. The molecular structure of ammonium O-(2-butyl)-4-methoxyphenyldithiophosphonate derivative was established by X-ray single crystal analysis. The dithiophosphonic acids obtained and their ammonium salts possessed high hydrolytic stability, antimicrobial activity and low cytotoxicity. The chemical behavior of dithiophosphonic acids and their salts in water and the Mueller-Hinton nutrient broth was established. The electrical conductivity dithiophosphonic acids and their salts in water and in a water–ethanol mixture was studied.

Keywords

Lawessons reagent, ammonia, hexadecylamine, antimicrobial activity, cytotoxicity

The name of the journal

Journal of Sulfur Chemistry

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=317457&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Nizamov Ilnar Damirovich	ru_RU
dc.contributor.author	Nizamov Ilyas Saidovich	ru_RU
dc.contributor.author	Salikhov Ramazan Zaytunovich	ru_RU
dc.contributor.author	Kalekulin Ivan Ilich	ru_RU
dc.contributor.author	Yakimov Vladimir Yurevich	ru_RU
dc.date.accessioned	2025-01-01T00:00:00Z	ru_RU
dc.date.available	2025-01-01T00:00:00Z	ru_RU
dc.date.issued	2025	ru_RU
dc.identifier.citation	Nizamov, I.S. Racemic 2-butanol, 2-ethylhexanol and malic ester in the synthesis of ammonium and hexadecylammonium dithiophosphonates with antimicrobial and cytotoxic activity / I.S. Nizamov, V.Yu. Yakimov, I.I. Kalekulin, I.D. Nizamov, R.Z. Salikhov, K.A. Ivshin, O.N. Kataeva, G.G. Garifzianova, D.Yu. Grishaev, M.P. Shulaeva, A.A. Parfenov, A.B. Vyshtakalyuk // J. Sulfur Chem. – 2025. – Vol., Is.. – P.1–19. (ISSN: 1741-5993 (Print) 1741-6000 (Online) Journal homepage: www.tandfonline.com/journals/gsrp20) DOI 10.1080/17415993.2025.2551759. WoS, Q3	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=317457&p_lang=2	ru_RU
dc.description.abstract	Journal of Sulfur Chemistry	ru_RU
dc.description.abstract	Dithiophosphonic acids were prepared by the reactions of Lawesson's reagent with racemic 2-butanol, 2-ethylhexanol and diethyl malate reacted with ammonia and hexade- cylamine to form ammonium and hexadecylammonium dithiophosphonates. The molecular structure of ammonium O-(2-butyl)-4-methoxyphenyldithiophosphonate derivative was established by X-ray single crystal analysis. The dithiophosphonic acids obtained and their ammonium salts possessed high hydrolytic stability, antimicrobial activity and low cytotoxicity. The chemical behavior of dithiophosphonic acids and their salts in water and the Mueller-Hinton nutrient broth was established. The electrical conductivity dithiophosphonic acids and their salts in water and in a water–ethanol mixture was studied.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Lawessons reagent	ru_RU
dc.subject	ammonia	ru_RU
dc.subject	hexadecylamine	ru_RU
dc.subject	antimicrobial activity	ru_RU
dc.subject	cytotoxicity	ru_RU
dc.title	Racemic 2-butanol, 2-ethylhexanol and malic ester in the synthesis of ammonium and hexadecylammonium dithiophosphonates with antimicrobial and cytotoxic activity	ru_RU
dc.type	Articles in international journals and collections	ru_RU