KFU. Card publication. Old Rats' Isolated Heart Reaction Upon Stimulation of Alpha2-Adrenergic Receptors

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FEDERAL UNIVERSITY

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OLD RATS' ISOLATED HEART REACTION UPON STIMULATION OF ALPHA2-ADRENERGIC RECEPTORS

Form of presentation

Articles in Russian journals and collections

Year of publication

2025

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Authors, employees of KFU

Biktemirova Raisa Gabdullovna, author

Zefirov Timur Lvovich, author

Ziyatdinova Nafisa Ilgizovna, author

Kupcova Anna Mikhaylovna, author

Authors, students KFU

Shaymardanova Gulnara Ferdinantovna, author

Bibliographic description in the original language

Kuptsova A.M. Old Rats' Isolated Heart Reaction Upon Stimulation of Alpha2-Adrenergic Receptors / A.M. Kuptsova / N.I. Ziyatdinova / G.F. Shaimardanova / R.G. Biktemirova / T.L. Zefirov // Opera Med Physiol. 2025. - Vol. 12 (3). - r. 108-114

Annotation

Aging is a natural and inevitable process that worsens the quality of life and shortens its duration. In the process of aging, the cardiovascular system undergoes significant restructuring, diastolic dysfunction is observed, vascular stiffness increases and vasodilation decreases. α2-ARs are widely distributed in the body and are involved in the regulation of heart and vascular functions. In pathological conditions, there is an increase in the expression of α2-AR subtypes, a violation of their functions, and a decrease in the effectiveness of the associated signalling cascades. The study aimed to investigate the effect of the α2-AR agonist clonidine hydrochloride at concentrations of 10-9-10-6 M on the inotropy, chronotropy and coronary flow of the old rats isolated heart. α2-AR stimulation changes all the studied parameters of the old rats isolated heart. The force of left the ventricular myocardium contraction decreases at concentrations of 10-9 and 10-8 M, and increases at concentrations of 10-7 and 10-6 M. The α2-AR agonist causes a decrease in heart rate in all studied concentrations. Stimulation of α2-AR in lower concentrations (10-9 - 10-7 M) reduces coronary flow, and the maximum concentration of clonidine hydrochloride (10-6 M) increases.

Keywords

α2-adrenergic receptorschronotropyinotropycoronary flowisolated heartrat

The name of the journal

Opera Medica et Physiologica

URL

https://operamedphys.org/content/old-rats%E2%80%99-isolated-heart-reaction-upon-stimulation-alpha2-adrenergic-receptors

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=317352&p_lang=2

Resource files

File name	Size (MB)	Format
F_OPERA_Kupcova_2.pdf	0,90	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Biktemirova Raisa Gabdullovna	ru_RU
dc.contributor.author	Zefirov Timur Lvovich	ru_RU
dc.contributor.author	Ziyatdinova Nafisa Ilgizovna	ru_RU
dc.contributor.author	Kupcova Anna Mikhaylovna	ru_RU
dc.contributor.author	Shaymardanova Gulnara Ferdinantovna	ru_RU
dc.date.accessioned	2025-01-01T00:00:00Z	ru_RU
dc.date.available	2025-01-01T00:00:00Z	ru_RU
dc.date.issued	2025	ru_RU
dc.identifier.citation	Kuptsova A.M. Old Rats' Isolated Heart Reaction Upon Stimulation of Alpha2-Adrenergic Receptors / A.M. Kuptsova / N.I. Ziyatdinova / G.F. Shaimardanova / R.G. Biktemirova / T.L. Zefirov // Opera Med Physiol. 2025. - Vol. 12 (3). - �. 108-114	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=317352&p_lang=2	ru_RU
dc.description.abstract	Opera Medica et Physiologica	ru_RU
dc.description.abstract	Aging is a natural and inevitable process that worsens the quality of life and shortens its duration. In the process of aging, the cardiovascular system undergoes significant restructuring, diastolic dysfunction is observed, vascular stiffness increases and vasodilation decreases. α2-ARs are widely distributed in the body and are involved in the regulation of heart and vascular functions. In pathological conditions, there is an increase in the expression of α2-AR subtypes, a violation of their functions, and a decrease in the effectiveness of the associated signalling cascades. The study aimed to investigate the effect of the α2-AR agonist clonidine hydrochloride at concentrations of 10-9-10-6 M on the inotropy, chronotropy and coronary flow of the old rats isolated heart. α2-AR stimulation changes all the studied parameters of the old rats isolated heart. The force of left the ventricular myocardium contraction decreases at concentrations of 10-9 and 10-8 M, and increases at concentrations of 10-7 and 10-6 M. The α2-AR agonist causes a decrease in heart rate in all studied concentrations. Stimulation of α2-AR in lower concentrations (10-9 - 10-7 M) reduces coronary flow, and the maximum concentration of clonidine hydrochloride (10-6 M) increases.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Old Rats' Isolated Heart Reaction Upon Stimulation of Alpha2-Adrenergic Receptors	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU