KFU. Card publication. АССОЦИАЦИЯ NADPH–ОКСИДАЗЫ 2 (NOX2) С РАЗВИТИЕМ АТОПИЧЕСКОЙ БРОНХИАЛЬНОЙ АСТМЫ

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АССОЦИАЦИЯ NADPH&NDASH;ОКСИДАЗЫ 2 (NOX2) С РАЗВИТИЕМ АТОПИЧЕСКОЙ БРОНХИАЛЬНОЙ АСТМЫ

Form of presentation

Articles in Russian journals and collections

Year of publication

2025

Язык

русский

Authors, employees of KFU

Abramova Zinaida Ivanovna, author

Bibliographic description in the original language

Ibragimov B. R. Associaciya NADPH–oksidazy 2 (NOX2) s razvitiem atopicheskoy bronkhialnoy astmy /B .R. Ibragimov, A. S. Demercidis, I.D. Reshetnikova, Yu. V. Skibo, S.N. Abramov, Z.I. Abramova //Biomedical Chemistry: Research and Methods.- 2025.-V.8,N.3.- e00272 DOI: 10.18097/bmcrm00272

Annotation

Biomedical Chemistry: Research and Methods.

Keywords

NOX2, NADPH?оксидаза 2, LС3?ассоциированный фагоцитоз, моноциты, атопическая бронхиальная астма

The name of the journal

Biomedical Chemistry: Research and Methods.

URL

http://www.bmc-rm.org/index.php/BMCRM/article/view/272

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=317300&p_lang=2

Resource files

File name	Size (MB)	Format
F_Statya__2025_ASSOCIACIYa_NADP__OKSIDAZY_2__NOX2__S_RAZVITIEM_ATOPIChESKOJ_BRONKhIALNOJ_ASTMY.pdf	1,41	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Abramova Zinaida Ivanovna	ru_RU
dc.date.accessioned	2025-01-01T00:00:00Z	ru_RU
dc.date.available	2025-01-01T00:00:00Z	ru_RU
dc.date.issued	2025	ru_RU
dc.identifier.citation	Ибрагимов Б. Р. Ассоциация NADPH–оксидазы 2 (NOX2) с развитием атопической бронхиальной астмы /Б .Р. Ибрагимов, А. С. Демерцидис, И.Д. Решетникова, Ю. В. Скибо, С.Н. Абрамов, З.И. Абрамова //Biomedical Chemistry: Research and Methods.- 2025.-V.8,N.3.- e00272 DOI: 10.18097/bmcrm00272	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=317300&p_lang=2	ru_RU
dc.description.abstract	Biomedical Chemistry: Research and Methods.	ru_RU
dc.description.abstract	Phagocytic cells destroy bacteria, allergens, and apoptotic cells via antimicrobial reactions coupled with phagocytosis, including eneration of reactive oxygen species (ROS) and delivery of hydrolytic enzymes from lysosomes to the phagosome. ROS produced by NADPH oxidase 2 (NOX2), are involved in the mechanism of LC3-associated phagocytosis; they participate in the development of innate and adaptive immune responses, leading to airway remodeling and hyperreactivity. The aim of this study was to investigate an association between NOX2 and the severity of atopic bronchial asthma (ABA). The level of ROS was determined in monocytes of healthy donors and patients with atopic bronchial asthma using dihydrorhodamine 123 (DHR-123). The expression level of NOX2 gene in monocytes of healthy donors and patients with atopic bronchial asthma was analyzed by RT-PCR. In the presence of PMA (phorbol 12-myristate 13-acetate), there was a significant increase in rhodamine-123 (Rho-123) fluorescence in all studied groups. At the same time, a significant increase in the median of Rho-123 fluorescence was found in the group with severe ABA as compared to healthy donors and patients with mild AAA, as well as to the group of patients with moderate ABA. A significant increase in NOX2 gene expression was found in the groups with moderate and severe ABA compared to the other studied groups. Based on the data obtained, it can be assumed that with an increase in the activity of NOX2, the key enzyme of LC3-associated phagocytosis, there is an aggravation of the course of ABA.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	NOX2	ru_RU
dc.subject	NADPH?оксидаза 2	ru_RU
dc.subject	LС3?ассоциированный фагоцитоз	ru_RU
dc.subject	моноциты	ru_RU
dc.subject	атопическая бронхиальная астма	ru_RU
dc.title	АССОЦИАЦИЯ NADPH–ОКСИДАЗЫ 2 (NOX2) С РАЗВИТИЕМ АТОПИЧЕСКОЙ БРОНХИАЛЬНОЙ АСТМЫ	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU