KFU. Card publication. Effects of 24-Hydroxycholesterol on the ATP-Induced Trigeminal Nerve Electrical Activity and the Mast Cells Degranulation

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EFFECTS OF 24-HYDROXYCHOLESTEROL ON THE ATP-INDUCED TRIGEMINAL NERVE ELECTRICAL ACTIVITY AND THE MAST CELLS DEGRANULATION

Form of presentation

Articles in Russian journals and collections

Year of publication

2025

Authors, employees of KFU

Ananev Anton Sergeevich, author

Gilizhdinova Karina Raulevna, author

Nurmieva Dinara Albertovna, author

Sitdikova Guzel Faritovna, author

Other authors

Petrov Aleksey Mikhaylovich

Authors, postgraduates KFU

Ananev Anton Sergeevich, postgraduate kfu

Gilizhdinova Karina Raulevna, postgraduate kfu

Nurmieva Dinara Albertovna, postgraduate kfu

Bibliographic description in the original language

Gilizhdinova, K. R., Nurmieva, D. A., Ananev, A. S., Petrov, A. M., & Sitdikova, G. F. (2025). Effects of 24-Hydroxycholesterol on the ATP-Induced Trigeminal Nerve Electrical Activity and the Mast Cells Degranulation. Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology, 19(1), 52-59.

Annotation

The trigeminovascular system plays a pivotal role in the generation of nociceptive activity, which underlies pain in migraine and includes trigeminal nerve afferents, dura mater vessels, and mast cells. Adenosine triphosphate (ATP) is one of the main mediators of the interaction between vessels, nerve endings, and mast cells. ATP activates P2X3 receptors of trigeminal nerve afferents and P2X7 receptors of mast cells. 24-Hydroxy cholesterol is the primary brain cholesterol metabolite synthesized by neurons and is capable of freely entering the bloodstream by crossing the blood?brain barrier. The purpose of this study was to examine the impact of 24-hydroxycholesterol on the electrical activity of trigeminal nerve afferents triggered by ATP application and on the mast cells degranulation in rat brain meninges. The electrical activity of the trigeminal nerve was recorded using an extracellular electrode in a rat hemiskull preparation, mast cells were stained with toluidine blue. 2

Keywords

ATP, 24-hydroxycholesterol, trigeminal nerve afferents, meninges, mast cells

Place of publication

��

The name of the journal

Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology

Publishing house

Pleiades Publishing

URL

https://link.springer.com/article/10.1134/S1990747824700454

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=314629&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Ananev Anton Sergeevich	ru_RU
dc.contributor.author	Gilizhdinova Karina Raulevna	ru_RU
dc.contributor.author	Nurmieva Dinara Albertovna	ru_RU
dc.contributor.author	Sitdikova Guzel Faritovna	ru_RU
dc.contributor.author	Ananev Anton Sergeevich	ru_RU
dc.contributor.author	Gilizhdinova Karina Raulevna	ru_RU
dc.contributor.author	Nurmieva Dinara Albertovna	ru_RU
dc.date.accessioned	2025-01-01T00:00:00Z	ru_RU
dc.date.available	2025-01-01T00:00:00Z	ru_RU
dc.date.issued	2025	ru_RU
dc.identifier.citation	Gilizhdinova, K. R., Nurmieva, D. A., Ananev, A. S., Petrov, A. M., & Sitdikova, G. F. (2025). Effects of 24-Hydroxycholesterol on the ATP-Induced Trigeminal Nerve Electrical Activity and the Mast Cells Degranulation. Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology, 19(1), 52-59.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=314629&p_lang=2	ru_RU
dc.description.abstract	Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology	ru_RU
dc.description.abstract	The trigeminovascular system plays a pivotal role in the generation of nociceptive activity, which underlies pain in migraine and includes trigeminal nerve afferents, dura mater vessels, and mast cells. Adenosine triphosphate (ATP) is one of the main mediators of the interaction between vessels, nerve endings, and mast cells. ATP activates P2X3 receptors of trigeminal nerve afferents and P2X7 receptors of mast cells. 24-Hydroxy cholesterol is the primary brain cholesterol metabolite synthesized by neurons and is capable of freely entering the bloodstream by crossing the blood?brain barrier. The purpose of this study was to examine the impact of 24-hydroxycholesterol on the electrical activity of trigeminal nerve afferents triggered by ATP application and on the mast cells degranulation in rat brain meninges. The electrical activity of the trigeminal nerve was recorded using an extracellular electrode in a rat hemiskull preparation, mast cells were stained with toluidine blue. 2	ru_RU
dc.language.iso	ru	ru_RU
dc.publisher	Pleiades Publishing	ru_RU
dc.subject	ATP	ru_RU
dc.subject	24-hydroxycholesterol	ru_RU
dc.subject	trigeminal nerve afferents	ru_RU
dc.subject	meninges	ru_RU
dc.subject	mast cells	ru_RU
dc.title	Effects of 24-Hydroxycholesterol on the ATP-Induced Trigeminal Nerve Electrical Activity and the Mast Cells Degranulation	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU