KFU. Card publication. Strategies to enhance the efficacy of FGF2-based therapies for skin wound healing

KAZAN
FEDERAL UNIVERSITY

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STRATEGIES TO ENHANCE THE EFFICACY OF FGF2-BASED THERAPIES FOR SKIN WOUND HEALING

Form of presentation

Articles in international journals and collections

Year of publication

2024

Authors, employees of KFU

Gomzikova Marina Olegovna, author

Kvon Anna Igorevna, author

Starostina Irina Georgievna, author

Syromyatnikova Valeriya Yurevna, author

Authors, postgraduates KFU

Kvon Anna Igorevna, postgraduate kfu

Bibliographic description in the original language

Syromiatnikova, V.Y., Kvon, A.I., Starostina, I.G. et al. Strategies to enhance the efficacy of FGF2-based therapies for skin wound healing. Arch Dermatol Res 316, 405 (2024). https://doi.org/10.1007/s00403-024-02953-x.

Annotation

Archives of Dermatological Research

Keywords

Basic fibroblast growth factor, skin regeneration, wound healing.

The name of the journal

Archives of Dermatological Research

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=311566&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Gomzikova Marina Olegovna	ru_RU
dc.contributor.author	Kvon Anna Igorevna	ru_RU
dc.contributor.author	Starostina Irina Georgievna	ru_RU
dc.contributor.author	Syromyatnikova Valeriya Yurevna	ru_RU
dc.contributor.author	Kvon Anna Igorevna	ru_RU
dc.date.accessioned	2024-01-01T00:00:00Z	ru_RU
dc.date.available	2024-01-01T00:00:00Z	ru_RU
dc.date.issued	2024	ru_RU
dc.identifier.citation	Syromiatnikova, V.Y., Kvon, A.I., Starostina, I.G. et al. Strategies to enhance the efficacy of FGF2-based therapies for skin wound healing. Arch Dermatol Res 316, 405 (2024). https://doi.org/10.1007/s00403-024-02953-x.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=311566&p_lang=2	ru_RU
dc.description.abstract	Archives of Dermatological Research	ru_RU
dc.description.abstract	Basic fibroblast growth factor (FGF2 or bFGF) is critical for optimal wound healing. Experimental studies show that local application of FGF2 is a promising therapeutic approach to stimulate tissue regeneration, including for the treatment of chronic wounds that have a low healing potential or are characterised by a pathologically altered healing process. However, the problem of low efficiency of growth factors application due to their rapid loss of biological activity in the aggressive proteolytic environment of the wound remains. Therefore, ways to preserve the efficacy of FGF2 for wound treatment are being actively developed. This review considers the following strategies to improve the effectiveness of FGF2-based therapy: (1) use of vehicles/carriers for delivery and gradual release of FGF2; (2) chemical modification of FGF2 to increase the stability of the molecule; (3) use of genetic constructs encoding FGF2 for de novo synthesis of protein in the wound. In addition, this review	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Basic fibroblast growth factor	ru_RU
dc.subject	skin regeneration	ru_RU
dc.subject	wound healing.	ru_RU
dc.title	Strategies to enhance the efficacy of FGF2-based therapies for skin wound healing	ru_RU
dc.type	Articles in international journals and collections	ru_RU