KFU. Card publication. Surface modification of silica nanoparticles by hexarhenium anionic cluster complexes for pH-sensing and staining of cell nuclei

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SURFACE MODIFICATION OF SILICA NANOPARTICLES BY HEXARHENIUM ANIONIC CLUSTER COMPLEXES FOR PH-SENSING AND STAINING OF CELL NUCLEI

Form of presentation

Articles in international journals and collections

Year of publication

2021

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Authors, employees of KFU

Daminova Amina Galeevna, author

Bibliographic description in the original language

Khazieva A. Surface modification of silica nanoparticles by hexarhenium anionic cluster complexes for pH-sensing and staining of cell nuclei / A. Khazieva, K. Kholin, I. Nizameev, K. Brylev, I. Kashnik, A. Voloshina, A. Lyubina, A. Gubaidullin, A. Daminova, K. Petrov, A. Mustafina, A. Mustafina // Journal of Colloid and Interface Science. - 2021. - V. 594. - P. 759–769.

Annotation

The surface deposition of luminescent anionic cluster complex [{Re6S8}(OH)6]4- advantages to the design and synthesis of composite luminescent silica nanoparticles (SNs) for intracellular imaging and sensing, while the encapsulation of the cluster units into SNs lacks for efficient luminescence. The deposition of the Re6 clusters resulted from their assembly at the silica surface functionalized by amino-groups provides the synthetic route for the composite SNs with bright cluster-centered luminescence invariable in pH range from 4.0 to 12.0. The pH-dependent supramolecular assembly of the cluster units with polyethyleneimine (PEI) at the silica surface is an alternative route for the synthesis of the composite SNs with high cluster-centered luminescence sensitive to pH-changes within 4.0-6.0. The sensitivity derives from the pH-driven conformational changes of PEI chains resulting in the release of the clusters from the PEI-based confinement under the acidification within pH 6.0-4.0. The potential of the composite SNs in cellular contrasting has been also revealed by the cell viability and flow cytometry measurements. It has been found that the PEI-supported embedding of the cluster units facilitates cell internalization of the composite SNs as well as results in specific intracellular distribution manifested by efficient staining of the cell nuclei in the confocal images.

Keywords

Cell internalization, Cellular contrast agent, Hexarhenium cluster, Luminescence, Polyethyleneimine, Silica nanoparticles, pH-sensing

The name of the journal

Journal of Colloid and Interface Science

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=310728&p_lang=2

Resource files

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F_1_s2.0_S0021979721003763_main.pdf	2,53	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Daminova Amina Galeevna	ru_RU
dc.date.accessioned	2021-01-01T00:00:00Z	ru_RU
dc.date.available	2021-01-01T00:00:00Z	ru_RU
dc.date.issued	2021	ru_RU
dc.identifier.citation	Khazieva A. Surface modification of silica nanoparticles by hexarhenium anionic cluster complexes for pH-sensing and staining of cell nuclei / A. Khazieva, K. Kholin, I. Nizameev, K. Brylev, I. Kashnik, A. Voloshina, A. Lyubina, A. Gubaidullin, A. Daminova, K. Petrov, A. Mustafina, A. Mustafina // Journal of Colloid and Interface Science. - 2021. - V. 594. - P. 759–769.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=310728&p_lang=2	ru_RU
dc.description.abstract	Journal of Colloid and Interface Science	ru_RU
dc.description.abstract	The surface deposition of luminescent anionic cluster complex [{Re6S8}(OH)6]4- advantages to the design and synthesis of composite luminescent silica nanoparticles (SNs) for intracellular imaging and sensing, while the encapsulation of the cluster units into SNs lacks for efficient luminescence. The deposition of the Re6 clusters resulted from their assembly at the silica surface functionalized by amino-groups provides the synthetic route for the composite SNs with bright cluster-centered luminescence invariable in pH range from 4.0 to 12.0. The pH-dependent supramolecular assembly of the cluster units with polyethyleneimine (PEI) at the silica surface is an alternative route for the synthesis of the composite SNs with high cluster-centered luminescence sensitive to pH-changes within 4.0-6.0. The sensitivity derives from the pH-driven conformational changes of PEI chains resulting in the release of the clusters from the PEI-based confinement under the acidification within pH 6.0-4.0. The potential of the composite SNs in cellular contrasting has been also revealed by the cell viability and flow cytometry measurements. It has been found that the PEI-supported embedding of the cluster units facilitates cell internalization of the composite SNs as well as results in specific intracellular distribution manifested by efficient staining of the cell nuclei in the confocal images.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Cell internalization	ru_RU
dc.subject	Cellular contrast agent	ru_RU
dc.subject	Hexarhenium cluster	ru_RU
dc.subject	Luminescence	ru_RU
dc.subject	Polyethyleneimine	ru_RU
dc.subject	Silica nanoparticles	ru_RU
dc.subject	pH-sensing	ru_RU
dc.title	Surface modification of silica nanoparticles by hexarhenium anionic cluster complexes for pH-sensing and staining of cell nuclei	ru_RU
dc.type	Articles in international journals and collections	ru_RU