KFU. Card publication. Temperature-sensitive emission of dialkylaminostyrylhetarene dyes and their incorporation into phospholipid aggregates: Applicability for thermal sensing and cellular uptake behavior

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TEMPERATURE-SENSITIVE EMISSION OF DIALKYLAMINOSTYRYLHETARENE DYES AND THEIR INCORPORATION INTO PHOSPHOLIPID AGGREGATES: APPLICABILITY FOR THERMAL SENSING AND CELLULAR UPTAKE BEHAVIOR

Form of presentation

Articles in international journals and collections

Year of publication

2022

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Authors, employees of KFU

Daminova Amina Galeevna, author

Bibliographic description in the original language

Akhmadeev B. S. Temperature-sensitive emission of dialkylaminostyrylhetarene dyes and their incorporation into phospholipid aggregates: applicability for thermal sensing and cellular uptake behavior / B. S. Akhmadeev, T. P. Gerasimova, A. R. Gilfanova, S. A. Katsyuba, L. N. Islamova, G. M. Fazleeva, A. A. Kalinin, A. G. Daminova, S. V. Fedosimova, S .K. Amerhanova, A. D. Voloshina, E. G. Tanysheva, O. G. Sinyashin, A. R. Mustafina // Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. - 2022. - V. 268, 120647

Annotation

A series of dialkylaminostyrylhetarene dyes constructed from electron-rich and electron-deficient moieties of various structures connected via vinylene p-bridges are introduced as temperature-sensitive luminophores. The temperature dependent emission of the dyes in the acidified dichloromethane solutions derives from temperature-induced shift of the equilibrium between neutral and protonated forms of the dyes. The heating-induced blue shift and intensification of emission of neutral form of the dyes make them a promising basis for development of nanoparticles exhibiting temperature-sensitivity in aqueous solutions at pH typical of biological liquids. Hydrophobicity-driven incorporation of the water insoluble dyes into L-a-phos phatidylcholine(PC)-based bilayers allows to obtain water dispersible dye-PC aggregates, and to follow their emission in the aqueous solutions. Structure of the dyes has strong impact on the efficacy of the dyes incorporation into the PC-based bilayers, temperature sensitivity of emission of the dye-PC aggregates and its reversibility under the heating/cooling cycles. This enables structural optimization of the dyes in order to obtain the dye-PC species demonstrating maximal temperature dependence and reversibility of their luminescence in aqueous solutions. The selected leader exhibits low cytotoxicity exemplified for MHeLa and Chang Liver cell lines, while the efficient cell internalization of the dye, manifested in the staining of the cell cytoplasm, opens further opportunities for biosensing applications.

Keywords

Dye, Structure?property relationship, Phospholipid bilayer,Cellular marking,Temperature sensitive luminescence

The name of the journal

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=310723&p_lang=2

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Full metadata record

Field DC	Value	Language
dc.contributor.author	Daminova Amina Galeevna	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Akhmadeev B. S. Temperature-sensitive emission of dialkylaminostyrylhetarene dyes and their incorporation into phospholipid aggregates: applicability for thermal sensing and cellular uptake behavior / B. S. Akhmadeev, T. P. Gerasimova, A. R. Gilfanova, S. A. Katsyuba, L. N. Islamova, G. M. Fazleeva, A. A. Kalinin, A. G. Daminova, S. V. Fedosimova, S .K. Amerhanova, A. D. Voloshina, E. G. Tanysheva, O. G. Sinyashin, A. R. Mustafina // Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. - 2022. - V. 268, 120647	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=310723&p_lang=2	ru_RU
dc.description.abstract	Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy	ru_RU
dc.description.abstract	A series of dialkylaminostyrylhetarene dyes constructed from electron-rich and electron-deficient moieties of various structures connected via vinylene p-bridges are introduced as temperature-sensitive luminophores. The temperature dependent emission of the dyes in the acidified dichloromethane solutions derives from temperature-induced shift of the equilibrium between neutral and protonated forms of the dyes. The heating-induced blue shift and intensification of emission of neutral form of the dyes make them a promising basis for development of nanoparticles exhibiting temperature-sensitivity in aqueous solutions at pH typical of biological liquids. Hydrophobicity-driven incorporation of the water insoluble dyes into L-a-phos phatidylcholine(PC)-based bilayers allows to obtain water dispersible dye-PC aggregates, and to follow their emission in the aqueous solutions. Structure of the dyes has strong impact on the efficacy of the dyes incorporation into the PC-based bilayers, temperature sensitivity of emission of the dye-PC aggregates and its reversibility under the heating/cooling cycles. This enables structural optimization of the dyes in order to obtain the dye-PC species demonstrating maximal temperature dependence and reversibility of their luminescence in aqueous solutions. The selected leader exhibits low cytotoxicity exemplified for MHeLa and Chang Liver cell lines, while the efficient cell internalization of the dye, manifested in the staining of the cell cytoplasm, opens further opportunities for biosensing applications.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Dye	ru_RU
dc.subject	Structure?property relationship	ru_RU
dc.subject	Phospholipid bilayer	ru_RU
dc.subject	Cellular marking	ru_RU
dc.subject	Temperature sensitive luminescence	ru_RU
dc.title	Temperature-sensitive emission of dialkylaminostyrylhetarene dyes and their incorporation into phospholipid aggregates: Applicability for thermal sensing and cellular uptake behavior	ru_RU
dc.type	Articles in international journals and collections	ru_RU